2024
Network state dynamics underpin basal craving in a transdiagnostic population
Ye J, Garrison K, Lacadie C, Potenza M, Sinha R, Goldfarb E, Scheinost D. Network state dynamics underpin basal craving in a transdiagnostic population. Molecular Psychiatry 2024, 1-10. PMID: 39183336, DOI: 10.1038/s41380-024-02708-0.Peer-Reviewed Original ResearchConnectome-based predictive modelingBrain responsesRegulation of affective statesSample of healthy controlsTransdiagnostic populationTransdiagnostic sampleHigher cravingMotivational stateCravingFMRI methodsAffective statesScan runsExperimental stimuliNetwork engagementBrain dynamicsClinical implicationsHealthy controlsBrainIndividual variationState dynamicsCharacterize individualsReplication datasetPsychopathologyFMRIEngagementrTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways
Li S, Ma X, Chen H, Wang M, Zheng Y, Yang B, Ni H, Potenza M, Dong G. rTMS effects on urges and severity of tobacco use disorder operate independently of a retrieval-extinction component and involve frontal-striatal pathways. Journal Of Affective Disorders 2024, 349: 21-31. PMID: 38190858, DOI: 10.1016/j.jad.2024.01.048.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexRepetitive transcranial magnetic stimulationSmoking cravingFunctional connectivityTobacco use disorderBrain regionsRetrieval-extinction procedureLeft dorsolateral prefrontal cortexSimilar neural correlatesFrontal-striatal pathwaysStandard repetitive transcranial magnetic stimulationUse disordersMedial frontal gyrusIncreased functional connectivitySham repetitive transcranial magnetic stimulationExecutive controlSmoking cuesNeural correlatesTranscranial magnetic stimulationBrain responsesFrontal gyrusGreater activationLess activationSmoking urgesBilateral insula
2020
Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task
Dong GH, Wang M, Zheng H, Wang Z, Du X, Potenza MN. Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task. Psychological Medicine 2020, 51: 1549-1561. PMID: 32102722, DOI: 10.1017/s003329172000032x.Peer-Reviewed Original ResearchConceptsInternet gaming disorderPosterior cingulate cortexRecreational game useIGD subjectsRGU subjectsNeurobiological markersGaming disorderCue-craving taskCue-reactivity taskGaming-related cuesCue-related cravingDynamic causal modelingPossible neurobiological mechanismsCognitive controlGaming cuesNeutral cuesUseful neurobiological markerPrefrontal regulationBrain responsesNeurobiological mechanismsLeft hemisphereCausal modelingCingulate cortexDirectional connectivityGame use