2017
Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)
Leon J, Hommer R, Grant P, Farmer C, D’Souza P, Kessler R, Williams K, Leckman JF, Swedo S. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). European Child & Adolescent Psychiatry 2017, 27: 637-643. PMID: 29119300, DOI: 10.1007/s00787-017-1077-9.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersIntravenous immunoglobulinStreptococcal infectionDose of IVIGNeuropsychiatric disordersPlacebo-controlled trialSignificant obsessive-compulsive symptomsPopulation of childrenCognitive behavioral therapySubacute illnessSydenham's choreaBlinded infusionChronic coursePsychiatric medicationsTreatment modalitiesSpecific symptomsChildhood-onset OCDLongitudinal courseNatural historyObsessive-compulsive symptomsBehavioral therapyExacerbationParents of participantsTelephone interviews
2014
Neural plasticity in fathers of human infants
Kim P, Rigo P, Mayes LC, Feldman R, Leckman JF, Swain JE. Neural plasticity in fathers of human infants. Social Neuroscience 2014, 9: 522-535. PMID: 24958358, PMCID: PMC4144350, DOI: 10.1080/17470919.2014.933713.Peer-Reviewed Original ResearchConceptsFathers' brainsNeural plasticityLateral prefrontal cortexCurrent longitudinal studyPosterior cingulate cortexVoxel-based morphometry analysisGray matter volumeNeural basisCognitive developmentNeural regionsNeural changesOrbitofrontal cortexPrefrontal cortexWeeks postpartumHuman fathersParental motivationCingulate cortexHuman infantsMood symptomsBrain regionsLongitudinal studyPostpartum mood symptomsMatter volumeMorphometry analysisHuman mothersCardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study
Dalsgaard S, Kvist AP, Leckman JF, Nielsen HS, Simonsen M. Cardiovascular Safety of Stimulants in Children with Attention-Deficit/Hyperactivity Disorder: A Nationwide Prospective Cohort Study. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 302-310. PMID: 24956171, PMCID: PMC4137345, DOI: 10.1089/cap.2014.0020.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderProspective cohort studyCardiovascular eventsCohort studyDose-response relationshipStimulant treatmentCardiovascular safetyHazard ratioRisk factorsFirst nationwide cohort studyNationwide prospective cohort studyPossible dose-response relationshipUnique personal identification numberCardiovascular adverse eventsCardiovascular risk factorsHyperactivity disorderNationwide cohort studyNational health registersStimulant usersPopulation-based sampleAdverse eventsHealth registersProspective followCox regressionPotential confounders
2010
Oxytocin and the Development of Parenting in Humans
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin and the Development of Parenting in Humans. Biological Psychiatry 2010, 68: 377-382. PMID: 20359699, PMCID: PMC3943240, DOI: 10.1016/j.biopsych.2010.02.005.Peer-Reviewed Original ResearchPredictors of early adulthood quality of life in children with obsessive–compulsive disorder
Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF. Predictors of early adulthood quality of life in children with obsessive–compulsive disorder. Social Psychiatry And Psychiatric Epidemiology 2010, 46: 291-297. PMID: 20191262, PMCID: PMC3645906, DOI: 10.1007/s00127-010-0194-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly adulthoodOCD symptomsImpaired Functioning ToolMethodsA longitudinal cohort studyLongitudinal cohort studyResultsForty-two percentSeverity of OCDAverage followClinical predictorsCohort studyPoor QoLResidual impairmentMild impairmentQoLSymptomsObjectivesThe goalAnxiety symptomsAdulthoodChildrenQoL.ChildhoodHoarding symptomsImpairmentDisorders
2009
Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder
Bloch MH, Craiglow BG, Landeros-Weisenberger A, Dombrowski PA, Panza KE, Peterson BS, Leckman JF. Predictors of Early Adult Outcomes in Pediatric-Onset Obsessive-Compulsive Disorder. Pediatrics 2009, 124: 1085-1093. PMID: 19786445, PMCID: PMC3974608, DOI: 10.1542/peds.2009-0015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge of OnsetChildChild, PreschoolCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMonitoring, PhysiologicMultivariate AnalysisObsessive-Compulsive DisorderPredictive Value of TestsProportional Hazards ModelsRisk FactorsSeverity of Illness IndexSex DistributionTic DisordersTime FactorsTourette SyndromeYoung AdultConceptsObsessive-compulsive disorderOCD symptomsBaseline clinical characteristicsPediatric-onset obsessive-compulsive disorderPersistent obsessive-compulsive disorderEarly adult outcomesLong-term outcomesMain outcome measuresLongitudinal cohort studyPercent of subjectsComorbid tic disordersOC symptomsHoarding symptomsAdult outcomesExperience remissionClinical characteristicsClinical predictorsCohort studyOppositional defiant disorderTic symptomsComorbid ticsEligible childrenTic disordersFemale genderOutcome measures
2006
Identification of pyruvate kinase as an antigen associated with Tourette syndrome
Kansy JW, Katsovich L, McIver KS, Pick J, Zabriskie JB, Lombroso PJ, Leckman JF, Bibb JA. Identification of pyruvate kinase as an antigen associated with Tourette syndrome. Journal Of Neuroimmunology 2006, 181: 165-176. PMID: 17011640, PMCID: PMC1853370, DOI: 10.1016/j.jneuroim.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmino Acid SequenceAnimalsAntibodies, BacterialAntigensAutoantibodiesBrainChildCross ReactionsHumansImmunohistochemistryLongitudinal StudiesMaleMiceMice, Inbred C57BLMolecular Sequence DataProspective StudiesPyruvate KinaseRatsSeroepidemiologic StudiesStreptococcal InfectionsTicsTourette SyndromeConceptsStreptococcal infectionObsessive-compulsive disorderTourette syndromeAutoimmune targetExacerbated symptomsBeta-hemolytic streptococcal infectionEarly-onset obsessive-compulsive disorderStreptococcal M proteinPediatric populationTic disordersImmune responseSurface antigenInfectious strainsSyndromeInfectionDisordersPyruvate kinaseM proteinPatientsImmunoreactivitySymptomsAntigenAntibodiesGlycolytic enzymesM1 isoform
2005
Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
Bloch MH, Leckman JF, Zhu H, Peterson BS. Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology 2005, 65: 1253-1258. PMID: 16247053, PMCID: PMC2367161, DOI: 10.1212/01.wnl.0000180957.98702.69.Peer-Reviewed Original ResearchConceptsSeverity of ticsBasal ganglia volumesCaudate nucleus volumeTourette syndromeObsessive-compulsive symptomsGanglia volumesEarly adulthoodObsessive-compulsive disorderTic symptomsCaudate nucleusCaudate volumeCross-sectional imaging studiesThalamo-cortical circuitsNucleus volumeSeverity of symptomsAge 16 yearsProspective longitudinal studyAge 14 yearsClinical statusClinical assessmentClinical measuresMorphologic disturbancesMRI scansSymptomsImaging studiesIncreased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process
2004
Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections
Luo F, Leckman JF, Katsovich L, Findley D, Grantz H, Tucker DM, Lombroso PJ, King RA, Bessen DE. Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections. Pediatrics 2004, 113: e578-e585. PMID: 15173540, DOI: 10.1542/peds.113.6.e578.Peer-Reviewed Original ResearchConceptsGABHS infectionSymptom exacerbationObsessive-compulsive disorderControl subjectsTourette syndromeAcute exacerbationTime pointsHealthy control subjectsBeta-hemolytic streptococciAcute inflammatory responseAcute symptom exacerbationsProspective longitudinal studyAutoimmune mechanismsPediatric patientsStreptococcal infectionNeuropsychiatric symptomsGABHS infectionsNonspecific markerInflammatory responseTic disordersUnselected groupObsessive-compulsive symptom severityExacerbationPatientsObsessive-compulsive symptoms