1989
Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method.
Riddle MA, Jatlow PI, Anderson GM, Cho SC, Hardin MT, Cohen DJ, Leckman JF. Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method. Neuropsychopharmacology 1989, 2: 123-9. PMID: 2742727, DOI: 10.1016/0893-133x(89)90015-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultDebrisoquinDose-Response Relationship, DrugFemaleHomovanillic AcidHumansIsoquinolinesMaleMethodsTourette SyndromeConceptsCentral nervous systemPeripheral HVA productionDebrisoquin sulfatePHVA levelsHomovanillic acidPlasma homovanillic acidCerebrospinal fluid samplesAssessment of reductionDopamine metabolismPlasma concentrationsNervous systemFluid samplesSubstantial inhibitionHVACN metabolismDoseComplete inhibitionDopamineSubjectsInhibitionMetabolismDebrisoquinLevelsPHVA
1988
Elevated CSF dynorphin A [1–8] in Tourette's syndrome
Leckman JF, Riddle MA, Berrettini WH, Anderson GM, Hardin M, Chappell P, Bissette G, Nemeroff CB, Goodman WK, Cohen DJ. Elevated CSF dynorphin A [1–8] in Tourette's syndrome. Life Sciences 1988, 43: 2015-2023. PMID: 2463450, DOI: 10.1016/0024-3205(88)90575-9.Peer-Reviewed Original ResearchConceptsPathobiology of TSTourette syndromeNeuroanatomic distributionEndogenous opioidsNeuropathological studiesObsessive-compulsive disorderPrevalence of TSBehavioral effectsPost-mortem brain studiesPathophysiology of TSGilles de la Tourette's syndromeCentral dopaminergic neuronsRecent neuropathological studiesLevels of dynorphinSevere Tourette syndromeBasal ganglia structuresChronic neuropsychiatric disorderLa Tourette's syndromeCentral monoaminergicCSF dynorphinElevated CSFStriatal fibersCSF studiesDopaminergic neuronsBasal ganglia
1987
Assessment of dopaminergic function in children and adults: long and brief debrisoquin administration combined with plasma homovanillic acid.
Riddle MA, Leckman JF, Anderson GM, Hardin MT, Ort SI, Towbin KE, Shaywitz BA, Cohen DJ. Assessment of dopaminergic function in children and adults: long and brief debrisoquin administration combined with plasma homovanillic acid. Psychopharmacology Bulletin 1987, 23: 411-4. PMID: 3481088.Peer-Reviewed Original Research
1986
Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration
Riddle MA, Leckman JF, Cohen DJ, Anderson M, Ort SI, Caruso KA, Shaywitz BA. Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration. Journal Of Neural Transmission 1986, 67: 31-43. PMID: 3465864, DOI: 10.1007/bf01243357.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlood PressureBrainChildDebrisoquinDopamineFemaleHomovanillic AcidHumansIsoquinolinesMaleMiddle AgedTourette SyndromeConceptsCentral dopaminergic functionDopaminergic functionHomovanillic acidDopamine metabolite homovanillic acidCentral DA activityChronic oral administrationPlasma-free homovanillic acidSingle oral doseBlood-brain barrierMetabolite homovanillic acidBehavioral side effectsOral dosePeripheral metabolismDA activityOral administrationSide effectsDebrisoquinAdministration methodsMarked reductionHVAAdministrationPeripheral formationAdultsValid techniqueChildren
1983
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Leckman JF, Cohen DJ. Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. Psychiatric Developments 1983, 1: 301-16. PMID: 6324164.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildClonidineCompulsive BehaviorDopamineFemaleHaloperidolHomovanillic AcidHumansMaleObsessive BehaviorObsessive-Compulsive DisorderParasympathomimeticsPhysostigmineReceptors, AdrenergicSerotoninSex FactorsTic DisordersTourette SyndromeConceptsTourette syndromeGilles de la Tourette's syndromeDopamine receptor hypersensitivityLa Tourette's syndromeChronic multiple ticsWaning of symptomsComplex stereotypiesReceptor hypersensitivityNeurochemical disturbancesClinical presentationMetabolic findingsCSF HVAMotor involvementDopamine blockersTS patientsObsessive-compulsive behaviorClinical practiceMultiple ticsGilles deNatural historyRostrocaudal progressionFamilial aggregationSyndromeSymptomsDisorders
1981
Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels
Leckman JF, Bowers MB, Sturges JS. Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels. American Journal Of Psychiatry 1981, 138: 472-477. PMID: 6163366, DOI: 10.1176/ajp.138.4.472.Peer-Reviewed Original Research