1986
Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration
Riddle MA, Leckman JF, Cohen DJ, Anderson M, Ort SI, Caruso KA, Shaywitz BA. Assessment or central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration. Journal Of Neural Transmission 1986, 67: 31-43. PMID: 3465864, DOI: 10.1007/bf01243357.Peer-Reviewed Original ResearchConceptsCentral dopaminergic functionDopaminergic functionHomovanillic acidDopamine metabolite homovanillic acidCentral DA activityChronic oral administrationPlasma-free homovanillic acidSingle oral doseBlood-brain barrierMetabolite homovanillic acidBehavioral side effectsOral dosePeripheral metabolismDA activityOral administrationSide effectsDebrisoquinAdministration methodsMarked reductionHVAAdministrationPeripheral formationAdultsValid techniqueChildren
1982
Clonidine in the treatment of Tourette syndrome: a review of data.
Leckman JF, Cohen DJ, Detlor J, Young JG, Harcherik D, Shaywitz BA. Clonidine in the treatment of Tourette syndrome: a review of data. Advances In Neurology 1982, 35: 391-401. PMID: 6756089.Peer-Reviewed Original ResearchConceptsTS patientsLong-term symptomatic improvementPathophysiology of TSDouble-blind trialEfficacy of clonidineMinority of patientsGrowth hormone releasePrimary pathogenic importanceMinimal side effectsSymptomatic improvementBlood pressureProfile of responseNoradrenergic mechanismsMHPG levelsTherapeutic responseHormone releaseClonidinePathogenic importanceAcute dosesSide effectsTourette syndromeBehavioral symptomsPharmacologic investigationsNeurochemical systemsPatients