2009
Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
Kataoka Y, Kalanithi PS, Grantz H, Schwartz ML, Saper C, Leckman JF, Vaccarino FM. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. The Journal Of Comparative Neurology 2009, 518: 277-291. PMID: 19941350, PMCID: PMC2846837, DOI: 10.1002/cne.22206.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsCholinergic interneuronsTourette syndromeNormal controlsCholinergic striatal interneuronsNumber of parvalbuminBrains of patientsCaudate nucleus volumeUnbiased stereological analysisStriatal interneuronsOngoing motor behaviorCholinergic cellsTotal neuronsCholine acetyltransferaseSpiny neuronsLimbic regionsStriatum of individualsTS patientsPostmortem brainsThalamic controlSensorimotor regionsInterneuronsCellular abnormalitiesNeuron firingTS subjects
2005
Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
Kalanithi PS, Zheng W, Kataoka Y, DiFiglia M, Grantz H, Saper CB, Schwartz ML, Leckman JF, Vaccarino FM. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13307-13312. PMID: 16131542, PMCID: PMC1201574, DOI: 10.1073/pnas.0502624102.Peer-Reviewed Original ResearchConceptsTourette syndromeNeuron distributionCalcium-binding protein parvalbuminNeuron numberT subjectsLower neuron numberGlobus pallidus pars externaParvalbumin-positive interneuronsTotal neuron numberUnbiased stereological techniquesChildhood neuropsychiatric disordersBasal ganglia tissueGABAergic neuronsGPi neuronsBasal gangliaCortico-striatoGlobus pallidusProtein parvalbuminThalamic circuitryGanglion tissueVocal ticsNormal controlsPutamen volumePars externaImaging studies
1993
Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images.
Peterson B, Riddle MA, Cohen DJ, Katz LD, Smith JC, Hardin MT, Leckman JF. Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images. Neurology 1993, 43: 941-9. PMID: 8492950, DOI: 10.1212/wnl.43.5.941.Peer-Reviewed Original ResearchConceptsBasal gangliaSyndrome patientsNormal controlsReduced basal ganglia volumeBasal ganglia volumesTourette syndrome patientsGlobus pallidus nucleusSmaller mean volumesPathogenesis of TSEsNeuroleptic exposureGanglia volumesPallidus nucleusNeuroradiologic studiesTourette syndromeVolumetric asymmetryMean volumeMagnetic resonance imagesGangliaAxial imagesSocioeconomic statusAsymmetry indexSyndromeResonance imagesVolume reductionMR scanner
1990
Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.
Leckman JF, Chittenden EH. Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis. L Encéphale 1990, 16 Spec No: 321-3. PMID: 2209489.Peer-Reviewed Original ResearchConceptsPathophysiology of TSGilles de la Tourette's syndromeObsessive-compulsive disorderLa Tourette's syndromeTourette syndromeOCD patientsCerebrospinal fluid studiesRecent neuropathological studiesEndogenous opioid peptidesMesocortical dopaminergic systemCases of OCDCSF dynorphinNeuropathological studiesCommon genetic diathesisRaphe nucleusBasal gangliaSerotoninergic systemSerotonergic systemClinical studiesDopaminergic systemCommon neural substrateTS patientsNeuropharmacological studiesOpioid peptidesNormal controls