2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinBrain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudate
2010
Perceived quality of maternal care in childhood and structure and function of mothers' brain
Kim P, Leckman JF, Mayes LC, Newman M, Feldman R, Swain JE. Perceived quality of maternal care in childhood and structure and function of mothers' brain. Developmental Science 2010, 13: 662-673. PMID: 20590729, PMCID: PMC3974609, DOI: 10.1111/j.1467-7687.2009.00923.x.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusSuperior temporal gyrusMaternal careTemporal gyrusHuman mothersFrontal gyrusInfant stimuliFusiform gyrusFirst postpartum monthLarger gray matter volumeGray matter volumeMagnetic resonance imagingHigh maternal careLow maternal careMother's brainPostpartum monthsLong-term effectsOrbital gyrusAnimal studiesBrain areasMatter volumeNeglectful motheringResonance imagingBrain regionsHeightened stress reactivity