2022
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson B, Shudlarski P, Anderson A, Zhang H, Gatenby J, Lacadie C, Leckman J, Gore J. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. 2022, 198-205. DOI: 10.4324/9780203822937-19.Peer-Reviewed Original ResearchMRI signal changesFunctional MRI signal changesFunctional debilityTourette syndromeTic suppressionNeuropsychiatric disordersNormal brain processesMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySignal changesFrequent causeBlood flowNeuronal activityImaging studiesStatistical significanceSignificant increaseSyndromeBehavioral problemsDebilityDisordersFailed inhibitionBrain processesImpulse controlIndirect measure
2012
Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity
Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity. Psychoneuroendocrinology 2012, 37: 1277-1285. PMID: 22281209, PMCID: PMC3936960, DOI: 10.1016/j.psyneuen.2011.12.021.Peer-Reviewed Original ResearchConceptsRomantic attachmentRomantic relationshipsNew loversRole of oxytocinParent-infant bondingBio-behavioral mechanismsHuman imaging studiesPositive affectAffectionate touchDyadic interactionsOxytocinergic systemBrain areasEmotional distressThree monthsDyadic statesImaging studiesRelationship durationOT levelsAdult HealthYoung adultsHigh individual stabilitySocial focusPlasma oxytocinOxytocinMonths
2005
Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
Bloch MH, Leckman JF, Zhu H, Peterson BS. Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology 2005, 65: 1253-1258. PMID: 16247053, PMCID: PMC2367161, DOI: 10.1212/01.wnl.0000180957.98702.69.Peer-Reviewed Original ResearchConceptsSeverity of ticsBasal ganglia volumesCaudate nucleus volumeTourette syndromeObsessive-compulsive symptomsGanglia volumesEarly adulthoodObsessive-compulsive disorderTic symptomsCaudate nucleusCaudate volumeCross-sectional imaging studiesThalamo-cortical circuitsNucleus volumeSeverity of symptomsAge 16 yearsProspective longitudinal studyAge 14 yearsClinical statusClinical assessmentClinical measuresMorphologic disturbancesMRI scansSymptomsImaging studiesAltered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
Kalanithi PS, Zheng W, Kataoka Y, DiFiglia M, Grantz H, Saper CB, Schwartz ML, Leckman JF, Vaccarino FM. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13307-13312. PMID: 16131542, PMCID: PMC1201574, DOI: 10.1073/pnas.0502624102.Peer-Reviewed Original ResearchConceptsTourette syndromeNeuron distributionCalcium-binding protein parvalbuminNeuron numberT subjectsLower neuron numberGlobus pallidus pars externaParvalbumin-positive interneuronsTotal neuron numberUnbiased stereological techniquesChildhood neuropsychiatric disordersBasal ganglia tissueGABAergic neuronsGPi neuronsBasal gangliaCortico-striatoGlobus pallidusProtein parvalbuminThalamic circuitryGanglion tissueVocal ticsNormal controlsPutamen volumePars externaImaging studies
1998
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.Peer-Reviewed Original ResearchConceptsTic suppressionTourette syndromeTic symptomsBasal gangliaPathogenesis of ticsVoluntary tic suppressionMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySubcortical neural circuitsFunctional magnetic resonance imagingMagnetic resonance imagingConnected cortical regionsRegional signal changesImpaired modulationSignal changesFunctional debilityNeuronal activityResonance imagingAdult subjectsImaging studiesCortical regionsNeuropsychiatric disordersNeural circuitsSyndrome