2024
Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression.
Lindley Baron-Cohen K, Fearon P, Meins E, Feldman R, Hardiman P, Rosan C, Fonagy P. Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. Development And Psychopathology 2024, 1-12. PMID: 39363731, DOI: 10.1017/s0954579424001585.Peer-Reviewed Original ResearchMaternal mind-mindednessMind-mindednessMind-related commentsStudy 1Study 2Mothers' appropriate mind-related commentsLevels of mind-mindednessMothers' caregiving representationsPostnatal depressionSymptoms of depressionParent-child interactionsChildren's social developmentEffects of OTParent-child relationshipMaternal depression scoresChildren's early developmentSample of mothersCaregiving representationsChild OT levelsSalivary OTDepression scoresOT levelsMaternal-infant attachmentPlacebo-controlledDepressionA meta-analytic examination of sensitive responsiveness as a mediator between depression in mothers and psychopathology in children
Borairi S, Deneault A, Madigan S, Fearon P, Devereux C, Geer M, Jeyanayagam B, Martini J, Jenkins J. A meta-analytic examination of sensitive responsiveness as a mediator between depression in mothers and psychopathology in children. Attachment & Human Development 2024, 26: 273-300. PMID: 38860779, DOI: 10.1080/14616734.2024.2359689.Peer-Reviewed Original ResearchMeta-analytic structural equation modelingIndirect pathwaysFree-play taskEnglish-speaking childrenMother-child interactionMeta-analytic examinationInternalizing psychopathologyExternalizing psychopathologyChild psychopathologyExternalizing behaviorsExternalizing problemsStructural equation modelingModeration analysisPsychopathologyTest moderationStructured tasksEquation modelingIndirect effectsDepressionExternalitiesModeratelyChildrenTaskSensitive responseMeta-analysisReviewing explore/exploit decision-making as a transdiagnostic target for psychosis, depression, and anxiety
Lloyd A, Roiser J, Skeen S, Freeman Z, Badalova A, Agunbiade A, Busakhwe C, DeFlorio C, Marcu A, Pirie H, Saleh R, Snyder T, Fearon P, Viding E. Reviewing explore/exploit decision-making as a transdiagnostic target for psychosis, depression, and anxiety. Cognitive, Affective, & Behavioral Neuroscience 2024, 24: 793-815. PMID: 38653937, PMCID: PMC11390819, DOI: 10.3758/s13415-024-01186-9.Peer-Reviewed Original ResearchTransdiagnostic targetAssociated with more explorationAssociated with psychopathologyReduced explorationPsychosisLongitudinal designAnxietyDepressionWell-poweredEveryday decisionsDecision-making contextDecision-makingIndividualsPsychopathologyCognitionDisordersSystematic searchEvidenceBiasInsufficient evidenceContext of decision-makingInterventionAcademic databasesContextStudy
2021
Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial
Lindley Baron-Cohen K, Feldman R, Fearon P, Fonagy P. Intranasal oxytocin administration improves mood in new mothers with moderate low mood but not in mothers with elevated symptoms of postnatal depression: A randomised controlled trial. Journal Of Affective Disorders 2021, 300: 358-365. PMID: 34843839, DOI: 10.1016/j.jad.2021.11.062.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScalePostnatal depressionOT administrationNew mothersLow moodPostnatal Depression ScaleCross-over designAntidepressant effectsMonths postpartumSevere scoresPND casesPND scoresSub-clinical levelsTreatment benefitDepression ScaleMood spectrumClinical diagnosisElevated symptomsAdministrationMood scoresMothersNegative moodWomenNeuropeptide hormoneDepressionThe impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries
Brown R, Eisner M, Walker S, Tomlinson M, Fearon P, Dunne M, Valdebenito S, Hughes C, Ward C, Sikander S, Osafo J, Madrid B, Baban A, Van Thang V, Fernando A, Murray A. The impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries. Journal Of Affective Disorders 2021, 295: 612-619. PMID: 34509077, DOI: 10.1016/j.jad.2021.08.066.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesPrenatal depressive symptomsMiddle-income countriesPrenatal depressionDepressive symptomsMaternal health careChildhood experiencesAntenatal careThird trimesterCohort evidenceACE exposureHigh-income countriesPostnatal periodExpectant mothersBaseline measurementsPostnatal attachmentSymptomsPath mediation analysisRelevant covariatesDepressionHealth careMothers' feelingsMothersPregnancy
2019
Personality and Outcome in Individuals With Treatment-Resistant Depression—Exploring Differential Treatment Effects in the Tavistock Adult Depression Study (TADS)
Rost F, Luyten P, Fearon P, Fonagy P. Personality and Outcome in Individuals With Treatment-Resistant Depression—Exploring Differential Treatment Effects in the Tavistock Adult Depression Study (TADS). Journal Of Consulting And Clinical Psychology 2019, 87: 433-445. PMID: 30998046, DOI: 10.1037/ccp0000391.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionTavistock Adult Depression StudyLong-term psychoanalytic psychotherapyDepression StudyLong-term treatmentHamilton Rating ScaleDifferential treatment effectsChronic formTreatment outcomesTreatment periodDepression severityTailor treatmentPatientsLarge effect sizesRating ScaleInfluence responsivenessDepressionTreatment effectsTreatmentEffect sizeTauPresent studySignificant changesOutcomesGrowth curves
2018
Attentional Control as a Predictor of Response to Psychological Treatment for Depression and Relapse up to 1 year After Treatment: A Pilot Cohort Study
Buckman J, Saunders R, Fearon P, Leibowitz J, Pilling S. Attentional Control as a Predictor of Response to Psychological Treatment for Depression and Relapse up to 1 year After Treatment: A Pilot Cohort Study. Behavioural And Cognitive Psychotherapy 2018, 47: 318-331. PMID: 30352633, PMCID: PMC6372070, DOI: 10.1017/s1352465818000590.Peer-Reviewed Original ResearchConceptsAttentional Control ScaleAttentional controlSelf-report measuresBrief self-report measurePsychological treatment servicesDepressive symptomsDepressed patientsResidual depressive symptomsPsychological treatmentIAPT servicesACS scoreSymptom measuresControl ScaleTherapy sessionsDepressive symptom severitySymptom severityLittle varianceObserved relapsesResidual symptomsDepressionSmall overall sample sizeTreatment servicesMeasuresTreatment outcomesOverall sample sizeNetworks of Depression and Anxiety Symptoms Across Development
McElroy E, Fearon P, Belsky J, Fonagy P, Patalay P. Networks of Depression and Anxiety Symptoms Across Development. Journal Of The American Academy Of Child & Adolescent Psychiatry 2018, 57: 964-973. PMID: 30522742, PMCID: PMC6290121, DOI: 10.1016/j.jaac.2018.05.027.Peer-Reviewed Original ResearchConceptsAnxiety symptomsEarly childhoodSymptom-symptom associationsBidirectional longitudinal associationsSpecific symptomsChild healthHuman Development StudySymptomsMaternal reportsLongitudinal associationsNetwork of depressionTime pointsStrong associationDepressionAge 5National InstituteCentral symptomsNonparametric permutation testsLongitudinal investigationDiagnostic boundariesSymptom structureEarly Child CareAssociationPresent studyChildhoodRisk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis
Buckman J, Underwood A, Clarke K, Saunders R, Hollon S, Fearon P, Pilling S. Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis. Clinical Psychology Review 2018, 64: 13-38. PMID: 30075313, PMCID: PMC6237833, DOI: 10.1016/j.cpr.2018.07.005.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentRecurrence of depressionModerate treatment responseMore enduring effectsMindfulness-based therapyCognitive diathesesCognitive controlAffective informationNeural mechanismsPsychological therapiesPsychosocial interventionsResidual symptomsEnduring effectPrescriptive indicesMaltreatmentFuture researchCausal pathwaysCausal mechanismsDepressionPrescriptive factorsLimbic pathwaysAdultsTreatment responseSymptomsConsequences
2016
Predicting treatment outcome in psychological treatment services by identifying latent profiles of patients
Saunders R, Cape J, Fearon P, Pilling S. Predicting treatment outcome in psychological treatment services by identifying latent profiles of patients. Journal Of Affective Disorders 2016, 197: 107-115. PMID: 26991365, DOI: 10.1016/j.jad.2016.03.011.Peer-Reviewed Original ResearchConceptsPsychological treatment servicesLatent profile analysisPsychological treatmentLatent profilesStandardized symptom measuresPsychological interventionsPsychological therapiesProfile analysisSymptom measuresSymptom domainsTreatment servicesTreatment outcomesSuitable interventionsLevel of attritionLongitudinal analysisBasic demographic informationInterventionDemographic informationAnxietyDifferent intensitiesTreatment responseOutcomesDepressionRoutine careDifferent groups
2015
Postnatal Depression, Mother–Infant Interactions, and Child Development
Murray L, Fearon P, Cooper P. Postnatal Depression, Mother–Infant Interactions, and Child Development. 2015, 139-164. DOI: 10.1002/9781118509722.ch9.Peer-Reviewed Original ResearchMother-child relationshipChild outcomesMaternal depressionSocio-emotional developmentPoor child outcomesMother-infant interactionPostnatal depressionAdverse child outcomesDevelopment of childrenPsychological functioningChildren's problemsChild developmentDepressed mothersDepressionRoutine clinical practiceEvidence-based measuresConsiderable bodyDifficultiesMaternal disordersParentingEffective treatmentClinical practiceNumber of areasFurther evidenceFunctioning
2014
Parenting difficulties and postnatal depression: implications for primary healthcare assessment and intervention.
Murray L, Cooper P, Fearon P. Parenting difficulties and postnatal depression: implications for primary healthcare assessment and intervention. Community Practitioner : The Journal Of The Community Practitioners' & Health Visitors' Association 2014, 87: 34-8. PMID: 25612413.Peer-Reviewed Original ResearchConceptsChild outcomesPoor cognitive developmentCognitive developmentPostnatal depressionDomain-specific associationsExternalising behaviour problemsMother-child relationshipChild's developmental stageAdverse child outcomesHostile parentingNon-depressed mothersInsecure attachmentParental difficultiesEmotional vulnerabilityInfant signsInfant distressMaternal insensitivityBehavior problemsExternalising problemsSet of assessmentsParentingChildren of mothersImpairmentDepressionChildrenBayesian inferences about the self (and others): A review
Moutoussis M, Fearon P, El-Deredy W, Dolan R, Friston K. Bayesian inferences about the self (and others): A review. Consciousness And Cognition 2014, 25: 67-76. PMID: 24583455, PMCID: PMC3989044, DOI: 10.1016/j.concog.2014.01.009.Peer-Reviewed Original ResearchConceptsInterpersonal representationsPrior beliefsUtility of outcomesAffective valenceActive inferenceInferred representationsSocial interactionPersonality disorderApproximate Bayesian inferenceSelfPsychiatric disordersNormative functionBeliefsMajor psychiatric disordersRepresentationBayesian inferenceDisordersInferenceValenceParanoiaLikely outcomeDepressionOutcomesSurpriseBrain
2011
Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age
Murray L, Arteche A, Fearon P, Halligan S, Goodyer I, Cooper P. Maternal Postnatal Depression and the Development of Depression in Offspring Up to 16 Years of Age. Journal Of The American Academy Of Child & Adolescent Psychiatry 2011, 50: 460-470. PMID: 21515195, DOI: 10.1016/j.jaac.2011.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild of Impaired ParentsChild, PreschoolDepression, PostpartumDepressive Disorder, MajorDysthymic DisorderFamily ConflictFemaleHumansInfantInterview, PsychologicalLife Change EventsLongitudinal StudiesMaleMass ScreeningObject AttachmentProspective StudiesResilience, PsychologicalRisk FactorsSocial SupportConceptsYears of ageDepressed mothersPostnatal depressionClinical depressionAdolescent depressionFamily adversityMain study outcomeMaternal postnatal depressionDevelopment of depressionProspective longitudinal studyDevelopmental risk pathwayIndex mothersOffspring riskProbable casesNondepressed mothersStudy outcomesChild vulnerabilityInsecure infant attachmentDepressionMothersLongitudinal studyRisk pathwaysFamily assessmentDevelopmental riskRisk