Matthew State, MD, PhD

Research Interests

Autistic Disorder; Mental Disorders; Child Development Disorders, Pervasive; Tourette Syndrome; Schizophrenia, Childhood; Tic Disorders; Asperger Syndrome

Research Organizations

Obsessive Compulsive Disorder Research Clinic

Program in Neurodevelopment and Regeneration

Research Summary

Our lab is interested in identifying and characterizing genes and genetic mechanisms involved in neuropsychiatric and neurodevelopmental disorders of childhood. Currently we are focused on Tourette syndrome (TS) and Obsessive Compulsive disorder (OCD), Autism and related pervasive developmental disorders, childhood onset schizophrenia and structural brain disorders. We have a long standing interest in the contribution of rare variation to these syndromes and focus on gene discovery as an avenue to elaborate molecular mechanisms of disease. We currently employ a range of approaches including traditional gene mapping in families demonstrating Mendelian inheritance, molecular cytogenetic analyses of de novo chromosomal rearrangements, and high throughput genomic approaches including genome wide copy number analyses and massively parallel sequencing.

Selected Publications

  • De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

    Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ, Willsey AJ, Ercan-Sencicek AG, DiLullo NM, Parikshak NN, Stein JL, Walker MF, Ober GT, Teran NA, Song Y, El-Fishawy P, Murtha RC, Choi M, Overton JD, Bjornson RD, Carriero NJ, Meyer KA, Bilguvar K, Mane SM, Sestan N, Lifton RP, Günel M, Roeder K, Geschwind DH, Devlin B, State MW. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 2012, 485:237-41.

  • Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

    Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, Davis L, Wright NR, Dhodapkar RM, DiCola M, DiLullo NM, Fernandez TV, Fielding-Singh V, Fishman DO, Frahm S, Garagaloyan R, Goh GS, Kammela S, Klei L, Lowe JK, Lund SC, McGrew AD, Meyer KA, Moffat WJ, Murdoch JD, O'Roak BJ, Ober GT, Pottenger RS, Raubeson MJ, Song Y, Wang Q, Yaspan BL, Yu TW, Yurkiewicz IR, Beaudet AL, Cantor RM, Curland M, Grice DE, Günel M, Lifton RP, Mane SM, Martin DM, Shaw CA, Sheldon M, Tischfield JA, Walsh CA, Morrow EM, Ledbetter DH, Fombonne E, Lord C, Martin CL, Brooks AI, Sutcliffe JS, Cook EH, Geschwind D, Roeder K, Devlin B, State MW. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70:863-85.

  • Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.

    Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tüysüz B, Caglayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandas S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 2010, 467:207-10.

  • L-histidine decarboxylase and Tourette's syndrome.

    Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW. L-histidine decarboxylase and Tourette's syndrome. The New England Journal Of Medicine 2010, 362:1901-8.

  • Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.

    Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. American Journal Of Human Genetics 2008, 82:165-73.

  • Sequence variants in SLITRK1 are associated with Tourette's syndrome.

    Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science (New York, N.Y.) 2005, 310:317-20.

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Contact Info

Matthew State, MD, PhD
Mailing Address
PO Box 207900
230 South Frontage Road

New Haven, CT 06520-7900