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12th Annual Yale Stem Cell Center Virtual Research Retreat

Yale Stem Cell Center 12th Annual Virtual Research Retreat

Register now for YSCC’s annual retreat – to be held all day on Friday, October 30th - using the below link:

https://yalesurvey.ca1.qualtrics.com/jfe/for m/SV_3azqDC1LjGbNUc5

Those who register now will receive Zoom link the week of the event, and will be invited to select a lunchtime breakout session with a speaker



Welcome & Opening Remarks 8:45 – 9:00 am

Haifan Lin, PhD Eugene Higgins Professor of Cell Biology, Professor of Genetics, Obstetrics, Gynecology and Reproductive Sciences, and Dermatology; Director, Yale Stem Cell Center

Session 1: Epigenetic drivers of hematopoiesis and cancer Session Chair: In-Hyun Park, PhD, Associate Professor of Genetics

9:00 - 9:20 am Shangqin Guo, PhD Associate Professor of Cell Biology An unusual cellular state occupied by the fast cycling hematopoietic progenitors

9:20 - 9:40 am Stephanie Halene, MD, PhD Associate Professor of Medicine (Hematology) High-resolution binding atlas of U2AF1 mutants uncovers new complexity in splicing alterations and kinetics in myeloid malignancies

9:40 - 10:00 am Qin Yan, PhD Associate Professor of Pathology Regulation of drug resistance and tumor immunity by KDM5B histone demethylase

10:00 - 10:15 am Selected trainee flash talks

Qiao Wu, (Guo Lab) Department of Cell Biology Cell fate regulation by nuclear-localized actins

Xiongzhuo Tang, (Lin Lab) Department of Cell Biology Function of PIWI in drosophila intestinal stem cells and gut development

Phan Duy, (Kahle Lab) Department of Neurosurgery A conserved residue in the RNA-binding NHL domain of the LET-7 target TRIM71/LIN-41 is required for mammalian brain morphogenesis and prenatal neural stem cell regulation

10:15 - 10:45 am Virtual coffee break

10:45 - 11:45 am Yale Stem Cell Center Keynote Speaker Juergen A. Knoblich, PhD Scientific Director, Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria Cerebral organoids: modelling human brain development and tumorigenesis in stem cell derived 3D culture

11:45 - 12:45 pm Lunch/Breakout Sessions with Juergen Knoblich and Charles Sawyers

Session 2: Embryonic development and epigenetics Session Chair: Kaelyn Sumigray, PhD Assistant Professor of Genetics

12:45 - 1:05 pm Zachary Smith, PhD Assistant Professor of Genetics Epigenetic regulation across major developmental transitions

1:05 - 1:25 pm Berna Sozen, PhD Assistant Professor of Genetics Reconstructing mammalian embryonic patterning in vitro with stem cells

1:25 - 1:45 pm Andrew Xiao, PhD Associate Professor of Genetics Epigenetic regulation in early development and cancer

1:45 – 2:00 pm Selected trainee flash talks

Yiqun Jiang, (Myung Lab) Department of Dermatology Mapping molecular steps in hair follicle dermal niche development

Nils Neuenkirchen/Tianshu Liu, (Lin Lab) Department of Cell Biology MIWI2 interacts with the de novo DNA methylation machinery

Shuangshuang Du, (Greco Lab) Department of Genetics Cells and structures that orchestrate skin regeneration captured by live imaging

Session 3: Lymphatics, lymph nodes, and lymphocytes in development and anti-cancer immunity Session Chair: Mandar Muzumdar, MD Assistant Professor of Genetics and Medical Oncology

2:00 - 2:20 pm Nikhil Joshi, PhD Assistant Professor of Immunobiology Developing genetically engineered animal models to investigate cancer immunology

2:20 - 2:40 pm Anne Eichmann, PhD Ensign Professor of Medicine (Cardiology) and Professor of Cellular and Molecular Physiology Tip cell guidance of retina angiogenesis

2:40 - 3:00 pm Jeffrey Ishizuka, MD, DPhil Assistant Professor of Medicine (Oncology) Targeting dsRNA editing to overcome resistance to immune checkpoint blockade

3:00 - 3:15 pm Selected trainee flash talks

Haoyang Wei, (Greco Lab) Department of Genetics Understanding principles of hair follicle stem cell niche architecture in adult mice

Dingyao Zhang, (Lu Lab) Department of Genetics A non-canonical role of toll-like receptor 9 regulates cancer progression through suppressing the TGF-beta pathway

Kaiti Duan, (Hsia Lab) Department of Surgery/Plastic Surgery Fibronectin induced human pluripotent stem cell derived vascular smooth muscle cells enhance endothelial network formation via fibroblast growth factor

3:15 - 3:30 pm Virtual coffee break

3:30 - 4:30 pm Yale Cancer Center/Yale Stem Cell Center Distinguished Speaker Charles L. Sawyers, MD Howard Hughes Medical Investigator; Marie-Josee and Henry R. Kravis Chair in Human Oncology and Pathogenesis; Chair, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Lineage plasticity in prostate cancer

Closing Remarks 4:30 pm

Diane Krause, MD, PhD Professor of Laboratory Medicine, Cell Biology and Pathology; Associate Director, Yale Stem Cell Center

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Conferences and Symposia