2017
Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation
Diamond J, Cantu E, Porteous M, Suzuki Y, Meyer K, Lederer D, Milewski R, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett J, Singh G, Costa J, Tobias J, Rodriguez H, Van Deerlin V, Olthoff K, Shaked A, Chang B, Christie J, Investigators T. Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation. American Journal Of Transplantation 2017, 17: 1770-1777. PMID: 28117940, PMCID: PMC5489369, DOI: 10.1111/ajt.14209.Peer-Reviewed Original ResearchConceptsPrimary graft dysfunctionGraft dysfunctionLung transplantationPeripheral blood gene expressionFirst transplant yearImmune regulation genesInflammasome-related proteinsDays of transplantBlood of patientsAdaptive immunity genesBlood gene expressionAllograft reperfusionTransplant yearClinical trialsPGD developmentGrade 3T cellsTransplantGene expressionHypothesis-driven genesRNA expressionGene expression changesReperfusionAllograftsPatients
2016
The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction
Abbas A, Diamond J, Chehoud C, Chang B, Kotzin J, Young J, Imai I, Haas A, Cantu E, Lederer D, Meyer K, Milewski R, Olthoff K, Shaked A, Christie J, Bushman F, Collman R. The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction. American Journal Of Transplantation 2016, 17: 1313-1324. PMID: 27731934, PMCID: PMC5389935, DOI: 10.1111/ajt.14076.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesDNA, ViralFemaleFollow-Up StudiesGenome, ViralGraft RejectionGraft SurvivalHumansLung TransplantationMaleMetagenomicsMiddle AgedPerioperative CarePrimary Graft DysfunctionPrognosisProspective StudiesRespiratory SystemRisk FactorsTissue DonorsTorque teno virusConceptsPrimary graft dysfunctionTorque teno virusGraft dysfunctionDonor lungsTTV levelsGreater immune activationTTV DNA levelsStandard clinical assaysRespiratory tract bacteriaPGD casesQuantitative polymerase chain reactionEarly morbidityLung allograftsLung transplantationPGD statusTTV replicationBronchoalveolar lavageControl recipientsImmune activationPolymerase chain reactionHealthy controlsBrain deathRecipient pairsTissue injuryDonor organs