2001
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.Peer-Reviewed Original ResearchConceptsWild-type cellsIGF-IR promoter activityAT cellsAtaxia telangiectasiaPromoter activityLevel of transcriptionHeterologous viral promotersDominant negative fragmentTyrosine kinase activityCell surface receptorsATM cDNAIGF-IR expressionIGF-IRInhibition of apoptosisATM functionAT syndromeKinase activityViral promotersCDNA resultsCell transformationInsulin-like growthATM geneSurface receptorsGrowth abnormalitiesExtreme radiosensitivity
2000
Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.
Zeng M, Narayanan L, Xu X, Prolla T, Liskay R, Glazer P. Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Research 2000, 60: 4889-93. PMID: 10987303.Peer-Reviewed Original Research
1995
p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.
Havre P, Yuan J, Hedrick L, Cho K, Glazer P. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research 1995, 55: 4420-4. PMID: 7671255.Peer-Reviewed Original ResearchConceptsHigh-risk E6P53 inactivationHPV16 E6Low-risk E6Human papillomavirus proteinsG1 arrestCell linesHPV16 E6 geneHPV11 E6Carcinoma cell linesColon carcinoma cell linePapillomavirus proteinsLow dosesHPV16 E7E6 geneClonal cell linesE7 bindsNormal p53RKO cellsTumor suppressor protein p53P53 degradationSuppressor protein p53P53E6Protein p53