2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2001
The generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCell MovementImmunohistochemistryMacaca fascicularisMacaca mulattaNeuronsOlfactory PathwaysPhenotypePrimatesConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeurons
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABA
1999
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan N, Artavanis-Tsakonas S, Rakic P. Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling. Science 1999, 286: 741-746. PMID: 10531053, DOI: 10.1126/science.286.5440.741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell CountCell DifferentiationCell MovementCell NucleusCell SizeCells, CulturedCerebral CortexContact InhibitionHumansLigandsMembrane ProteinsMiceMitosisNeuritesNeuronsProtein Structure, TertiaryReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceSignal TransductionTranscription FactorsTranscriptional ActivationUp-RegulationConceptsNeurite growthMouse cerebral cortexCapacity of neuronsCortical neurite growthStudy of neuronsInhibition of NotchCerebral cortexNotch signalingCortical neuronsNotch activityMature neuronsInterneuronal contactsRetraction of neuritesHigh Notch activityNeuronsNeuronal growthNeuritesContact-dependent inhibitionExuberant growthNeurite extensionNotch receptorsInhibitionLow Notch activitySignalingActivity
1996
Spatiotemporal gradients of cell genesis in the primate retina.
Rapaport D, Rakic P, LaVail M. Spatiotemporal gradients of cell genesis in the primate retina. Perspectives On Developmental Neurobiology 1996, 3: 147-59. PMID: 8931090.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageMacaca mulattaMorphogenesisPigment Epithelium of EyeRetinaConceptsRetinal ganglion cellsGanglion cellsCell genesisMonkey retinal ganglion cellsLonger survival periodRetinal pigment epitheliumAmacrine cellsPrimate retinaMüller cellsSurvival periodMacaque retinaSoma diameterBipolar cellsPigment epitheliumRetinal structureHorizontal cellsMacaque monkeysVisual developmentCone photoreceptorsBrain structuresFunctional classRetinaProgenitor cellsRod photoreceptorsCardinal eventDevelopment of photoreceptor mosaics in the primate retina.
Wikler K, Rakic P. Development of photoreceptor mosaics in the primate retina. Perspectives On Developmental Neurobiology 1996, 3: 161-75. PMID: 8931091.Peer-Reviewed Original ResearchConceptsPrimate retinaPhotoreceptor mosaicAdult primate retinaCentral nervous systemRatio of rodsNervous systemRetinaTopographic arrangementRetinal coordinatesCone subtypesScotopic visionAvailable dataSubtypesTransient appearanceColor visionNeuronal arraysPhotoreceptor subtypesPhenotypePrimatesDifferent visual habitatsDifferent primatesRegional differencesPrimate species
1995
Genesis of the retinal pigment epithelium in the macaque monkey
Rapaport D, Rakic P, Yasamura D, LaVail M. Genesis of the retinal pigment epithelium in the macaque monkey. The Journal Of Comparative Neurology 1995, 363: 359-376. PMID: 8847405, DOI: 10.1002/cne.903630303.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyCell DifferentiationFemaleMacaca mulattaPigment Epithelium of EyePregnancyRetinaThymidineConceptsRetinal pigment epitheliumCell genesisRPE cellsPeripheral retinaRadiolabelled cellsPigment epitheliumRhesus monkey fetusesCells/Embryonic day 25Time of birthMonkey fetusesCentral retinaPostnatal monthPostnatal periodLabeling indexDay 204Macaque monkeysDay 25RetinaJuvenile retinaOptic cupEpitheliumHigh rateNeuroretinaLast cellRadial versus tangential migration of neuronal clones in the developing cerebral cortex.
Rakic P. Radial versus tangential migration of neuronal clones in the developing cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11323-11327. PMID: 8524778, PMCID: PMC40392, DOI: 10.1073/pnas.92.25.11323.Peer-Reviewed Original Research
1994
An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina.
Wikler K, Rakic P. An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6534-6538. PMID: 7912829, PMCID: PMC44237, DOI: 10.1073/pnas.91.14.6534.Peer-Reviewed Original ResearchConceptsFetal monkey retinaMonkey retinaRetinal ganglion cellsSubset of conesRed/green opsinImportant developmental markersGanglion cellsPrimate retinaGreen-sensitive conesDistinct antigensPhotoreceptor phenotypeRetinaMonoclonal antibodiesPhotoreceptor mosaicCone differentiationDevelopmental markersAntibodiesImmature regionsSame patternGreen opsinsAntigenSynaptogenesisSubset
1991
Glial Cells in Development
RAKIC P. Glial Cells in Development. Annals Of The New York Academy Of Sciences 1991, 633: 96-99. PMID: 1789598, DOI: 10.1111/j.1749-6632.1991.tb15599.x.Peer-Reviewed Original ResearchRelation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina
Wikler K, Rakic P. Relation of an array of early-differentiating cones to the photoreceptor mosaic in the primate retina. Nature 1991, 351: 397-400. PMID: 1827876, DOI: 10.1038/351397a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationEye ProteinsGestational AgeImmunologic TechniquesMacaca mulattaPhotoreceptor CellsRetinaRod OpsinsConceptsSubset of conesCone subtypesAdult rhesus monkeysRetinal mosaicsBlue-sensitive conesPrimate retinaRetinal surfaceImmunocytochemical evidenceRhesus monkeysPhenotypic specificationInner segmentsConfocal laser microscopySubtypesRetinaWeeksUndifferentiated regionDiurnal primatesLaser microscopyMonthsSynapsesGlial cell lineage in the cerebral cortex: A review and synthesis
Cameron R, Rakic P. Glial cell lineage in the cerebral cortex: A review and synthesis. Glia 1991, 4: 124-137. PMID: 1827774, DOI: 10.1002/glia.440040204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCell DifferentiationCerebral CortexEmbryonic and Fetal DevelopmentHumansMammalsNerve Tissue ProteinsNeurogliaNeuronsStem CellsConceptsCerebral cortexCell lineagesCell lineage relationshipsGlial cellsCortical gliogenesisCell-cell interactionsProgenitor cell poolGlial cell lineagesCentral nervous systemLineage relationshipsNervous systemCell poolLineagesGliogenesisCortexPresent reviewFunctional levelCellsPrecise timingDiversityReviewSeries of stepsCerebrum
1990
Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum
Meinecke D, Rakic P. Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum. Brain Research 1990, 55: 73-86. PMID: 2170058, DOI: 10.1016/0165-3806(90)90107-a.Peer-Reviewed Original ResearchConceptsGABAA receptor subunitsGranule cellsSynaptic circuitsGABAA receptorsPresynaptic elementsReceptor labelingReceptor subunitsGABAA/benzodiazepine receptor complexGolgi II neuronsInhibitory synaptic circuitsSpecific synaptic circuitsGranular layerInhibitory transmitter GABAFifth postnatal dayGABAA receptor complexCentral nervous systemCerebellum of ratsBenzodiazepine receptor complexMature granule cellsReceptor complexPresence of GABAInternal granular layerAlpha 1 subunitGABA transmittersGABAergic afferentsNeurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey
Kordower J, Rakic P. Neurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey. The Journal Of Comparative Neurology 1990, 291: 637-653. PMID: 2329194, DOI: 10.1002/cne.902910410.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBasal GangliaCell DifferentiationEmbryonic and Fetal DevelopmentGestational AgeMacacaMacaca mulattaThymidineConceptsBasal forebrain nucleiMagnocellular basal forebrain nucleiBasal forebrainForebrain nucleiRhesus monkeysAnterior basal forebrainEmbryonic day 27Early postnatal periodPeak of neurogenesisCortical-cortical connectionsNucleus basalisNeurogenic gradientCortical neuronsDays gestationMagnocellular neuronsPostnatal periodTarget neuronsNeuronal genesisCortical mantleMagnocellular nucleusPregnant animalsDay 27Intermediate divisionGestationPosterior division
1988
Defects of neuronal migration and the pathogenesis of cortical malformations
Rakic P, Swaab D. Defects of neuronal migration and the pathogenesis of cortical malformations. Progress In Brain Research 1988, 73: 15-37. PMID: 3047794, DOI: 10.1016/s0079-6123(08)60494-x.Peer-Reviewed Original Research
1987
Synaptogenesis in the primate retina proceeds from the ganglion cells towards the photoreceptors
Nishimura Y, Rakic P. Synaptogenesis in the primate retina proceeds from the ganglion cells towards the photoreceptors. Neuroscience Research Supplements 1987, 6: s253-s268. PMID: 3317146, DOI: 10.1016/0921-8696(87)90021-1.Peer-Reviewed Original Research
1984
Cytodifferentiation and synaptogenesis in the neostriatum of fetal and neonatal rhesus monkeys
Brand S, Rakic P. Cytodifferentiation and synaptogenesis in the neostriatum of fetal and neonatal rhesus monkeys. Brain Structure And Function 1984, 169: 21-34. PMID: 6721218, DOI: 10.1007/bf00300583.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaudate NucleusCell DifferentiationMacacaMacaca mulattaMicroscopy, ElectronPutamenSynapsesTime FactorsConceptsSynaptic densityDendritic shaftsFetal monthAsymmetric synapsesRhesus monkeysPostnatal rhesus monkeysNeonatal rhesus monkeysRound clear vesiclesFirst postnatal monthNeuronal cell bodiesShafts of dendritesGolgi impregnation methodEmbryonic day 60Axospinous synapsesSymmetric synapsesPresynaptic profilesPleomorphic vesiclesGlial cellsPostnatal monthAxonal profilesCaudate nucleusDendritic processesPostnatal developmentClear vesiclesCell bodies
1983
Gradients of cellular maturation and synaptogenesis in the superior colliculus of the fetal rhesus monkey
Cooper M, Rakic P. Gradients of cellular maturation and synaptogenesis in the superior colliculus of the fetal rhesus monkey. The Journal Of Comparative Neurology 1983, 215: 165-186. PMID: 6853771, DOI: 10.1002/cne.902150205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionMacaca mulattaMicroscopy, ElectronSuperior ColliculiSynapsesConceptsSuperficial superior colliculusDifferentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study
Duffy C, Rakic P. Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study. The Journal Of Comparative Neurology 1983, 214: 224-237. PMID: 6841685, DOI: 10.1002/cne.902140210.Peer-Reviewed Original ResearchConceptsGranule cell dendritesDentate gyrusCell dendritesDendritic spinesGranule cellsRhesus monkeysPostnatal rhesus monkeysQuantitative Golgi studyHippocampal granule cellsPostnatal day 3Time of birthRapid Golgi methodLength of dendritesDendritic lengthDendritic shaftsNeonatal levelsGolgi studyDistal thirdHippocampal regionDendritic branchingAdult monkeysDay 3Postnatal developmentGolgi methodLevel of maturation
1982
The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey.
Levitt P, Rakic P. The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Brain Research 1982, 256: 35-57. PMID: 7093728, DOI: 10.1016/0165-3806(82)90095-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiogenic AminesBrain StemCell DifferentiationDNA ReplicationFemaleLocus CoeruleusMacaca mulattaNeuronsPregnancyRaphe NucleiSubstantia NigraConceptsRaphe nucleusMA neuronsLocus coeruleusMonoamine neuronsSubstantia nigraRhesus monkeysPostnatal rhesus monkeysMajority of neuronsVentral tegmental areaProliferation of neuronsSeries of fetusesSN neuronsRaphe magnusBrain stemTegmental areaRaphe dorsalisGestational periodSynaptic targetsMedial partVentricular zoneLateral portionNeuronsFinal mitosisEmbryonic dayMonkeys