2023
Origin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original Research
2009
Evolution of the neocortex: a perspective from developmental biology
Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nature Reviews Neuroscience 2009, 10: 724-735. PMID: 19763105, PMCID: PMC2913577, DOI: 10.1038/nrn2719.Peer-Reviewed Original ResearchConceptsEvo-devo approachSpecies-specific adaptationsExtinct common ancestorsNew cell typesSpecies-specific differencesMutations of genesProliferative ventricular zoneMammalian evolutionDistinct migratory pathwaysCommon ancestorDevelopmental biologyCell divisionNew traitsNew cell subtypesNeural stem cellsProtomap hypothesisMouse embryosNew cytoarchitectonic areasTranscriptional factorsUnique cognitive abilitiesGene expressionDifferential enlargementDistinct traitsMigratory pathwaysCortical evolutionIntegration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009, 461: 524-528. PMID: 19759535, PMCID: PMC2874978, DOI: 10.1038/nature08362.Peer-Reviewed Original ResearchConceptsNeocortical excitatory neuronsRadial glial fibersColumnar organizationEphA/ephrinCerebral cortexFunctional impairmentNeuronal clonesExcitatory neuronsGlial fibersTangential migrationCortical columnsNeural progenitorsCircuit developmentEphrinProliferative unitsPopulationClonal populationsCortexNeurons
2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampusNeurocreationism--Making New Cortical Maps
Rakic P. Neurocreationism--Making New Cortical Maps. Science 2001, 294: 1011-1012. PMID: 11691974, DOI: 10.1126/science.294.5544.1011.Peer-Reviewed Original Research
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABARadial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical developmentMolecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinase
1998
Brain Development, VI: Radial Migration and Cortical Evolution
RAKIC P. Brain Development, VI: Radial Migration and Cortical Evolution. American Journal Of Psychiatry 1998, 155: 1150-1151. PMID: 9734535, DOI: 10.1176/ajp.155.9.1150.Peer-Reviewed Original ResearchChanges in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack D, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1242-1246. PMID: 9448316, PMCID: PMC18732, DOI: 10.1073/pnas.95.3.1242.Peer-Reviewed Original ResearchConceptsCell divisionCell division cycleCell cycle kineticsProgenitor cell divisionCell cycle lengthCell cycle durationEvolutionary modificationsEvolutionary expansionCerebral ventricular zoneDevelopmental basisCell productionPrimate neocortexS-phase labelingAnthropoid primatesProgenitor cellsFetal rhesus monkeysNeurogenetic periodVentricular zoneNeocortical sizeCortical cellsNeurogenesisCortical developmentMonkey cortexTotal roundsCortical layers