2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationships
2005
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal Of Nuclear Medicine 2005, 46: 745-51. PMID: 15872345.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenetic TestingHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMicrosatellite RepeatsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticRadionuclide ImagingRadiopharmaceuticalsTissue DistributionConceptsStriatal DAT availabilityDAT availabilityDopamine transporterDAT genotypeDopamine transporter availabilityBrain uptakeTransporter availabilityHealthy European AmericansDAT levelsCarbomethoxy-3betaClinical phenotypeMean increaseNeuropsychiatric diseasesSLC6A3 polymorphismsVNTR polymorphismSLC6A3European AmericansSLC6A3 geneHomozygotesHuman clinical phenotypesSubregion analysisPolymorphismDivergent resultsAssociationCommon alleles
2001
The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans
Martinez D, Gelernter J, Abi-Dargham A, van Dyck C, Kegeles L, Innis R, Laruelle M. The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans. Neuropsychopharmacology 2001, 24: 553-560. PMID: 11282255, DOI: 10.1016/s0893-133x(00)00216-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphetamineAttention Deficit Disorder with HyperactivityBenzamidesCarrier ProteinsCocaineCocaine-Related DisordersDopamineDopamine AntagonistsDopamine Plasma Membrane Transport ProteinsGenotypeHumansIodine RadioisotopesMembrane GlycoproteinsMembrane Transport ProteinsMinisatellite RepeatsNeostriatumNerve Tissue ProteinsPhenotypePolymorphism, GeneticPsychotic DisordersPyrrolidinesRadiopharmaceuticalsSchizophreniaTomography, Emission-Computed, Single-PhotonConceptsAmphetamine-induced dopamine releaseDopamine releaseDAT expressionDopamine transporterDifferent patient populationsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeurochemical phenotypePatient populationHealthy controlsDAT densityComputerized emission tomographyDopamine transmissionClinical phenotypeDiagnostic groupsSignificant associationEmission tomographyCocaine-induced paranoiaHyperactivity disorderTandem repeat polymorphismVNTR polymorphismDopamine transporter geneRepeat polymorphismTotal sample
2000
Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report
Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report. American Journal Of Psychiatry 2000, 157: 1700-1703. PMID: 11007732, DOI: 10.1176/appi.ajp.157.10.1700.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsDNADopamineDopamine Plasma Membrane Transport ProteinsFemaleGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMinisatellite RepeatsNerve Tissue ProteinsPolymerase Chain ReactionPolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-Photon
1998
Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))
Gelernter J, Kranzler H, Lacobelle J. Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF)). Genomics 1998, 52: 289-297. PMID: 9790747, DOI: 10.1006/geno.1998.5454.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApolipoproteins ECarrier ProteinsCiliary Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsGenetics, PopulationGenotypeHumansMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPolymorphism, GeneticReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Opioid, muTryptophan HydroxylaseConceptsCiliary neurotrophic factor
1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsChromosome MappingCrossing Over, GeneticDopamine Plasma Membrane Transport ProteinsFemaleGenetic LinkageHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPedigreeTourette SyndromeConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein gene
1994
Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia
Gelernter J, Kranzler H, Satel S, Rao P. Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia. Neuropsychopharmacology 1994, 11: 195-200. PMID: 7865100, DOI: 10.1038/sj.npp.1380106.Peer-Reviewed Original Research