2022
Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort
Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.Peer-Reviewed Original ResearchConceptsSmoking statusNicotine dependenceVeteran cohortNon-current smokersSerious public health issueNovel treatment strategiesPublic health issueUS military veteransEpigenome-wide association studiesCurrent smokersTreatment strategiesFagerström TestNicotine addictionSmokingHealth issuesRole of epigeneticsMilitary veteransMethylationEPIC BeadChip arraySmokersContinuous variablesF2RL3 geneCohortBiomarkersBeadChip arrayPrevious findings
2013
COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
Herman AI, Jatlow PI, Gelernter J, Listman JB, Sofuoglu M. COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. The Pharmacogenomics Journal 2013, 13: 490-497. PMID: 23459442, PMCID: PMC3675163, DOI: 10.1038/tpj.2013.1.Peer-Reviewed Original ResearchConceptsVal/Val genotypeAbstinent smokersVal genotypeGreater systolic blood pressureOvernight abstinent smokersVal158Met polymorphismSystolic blood pressureDoses of nicotineCatechol-O-methyltransferase (COMT) Val158Met polymorphismVal/ValEuropean American smokersNegative subjective effectsCOMT Val158Met polymorphismBlood pressureSmoking cessationAA smokersRisk factorsAmerican smokersIntravenous nicotineWithdrawal severityOvernight abstinenceSmokersNicotine addictionNicotine useSubjective effects