2011
Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol Dependence
Milivojevic V, Kranzler HR, Gelernter J, Burian L, Covault J. Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol Dependence. Alcohol Clinical And Experimental Research 2011, 35: 946-952. PMID: 21323680, PMCID: PMC3083475, DOI: 10.1111/j.1530-0277.2010.01425.x.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid Dehydrogenases3-Oxo-5-alpha-Steroid 4-DehydrogenaseAdultAlcoholismAldo-Keto Reductase Family 1 Member C3Base SequenceCase-Control StudiesFemaleGenetic VariationHumansHydroxyprostaglandin DehydrogenasesMaleMembrane ProteinsMiddle AgedMolecular Sequence DataPolymorphism, Single NucleotideYoung AdultConceptsEndogenous neuroactive steroidsNeuroactive steroidsAlcohol dependenceAlcohol effectsType 2Minor alleleNon-Hispanic CaucasiansRatio of dihydrotestosteroneBladder cancerG alleleC alleleSteroid biosynthetic enzymesType 1Important mediatorKey mediatorSteroidsSingle nucleotide polymorphismsCase-control sampleHuman brainType IMarkersBiological phenotypesNucleotide polymorphismsIndirect evidenceMediators
2004
Allelic and haplotypic association of GABRA2 with alcohol dependence
Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.Peer-Reviewed Original ResearchConceptsAlcohol-dependent subjectsAlcohol dependenceSingle nucleotide polymorphismsMajor depressive episodeGABAA receptor subunitsSubstance use disordersHaplotypic associationsEvidence of associationSerious morbidityOpioid dependenceAlpha 2 subunitDepressive episodePrevalent disorderUse disordersEuropean-American subjectsNeurotransmitter receptorsControl groupDrug dependenceReceptor subunitsCommon haplotypeGABRA2 geneBehavioral effectsImportant mediatorAssociationSubjects