2011
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAspergillosis, Allergic BronchopulmonaryAspergillus fumigatusAsthmaBlotting, WesternBronchial HyperreactivityCase-Control StudiesChemokine CXCL9Chronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrosisHumansImmunoenzyme TechniquesImmunoglobulin GLungMiceMice, Inbred C57BLOligodeoxyribonucleotidesReceptors, Interleukin-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerToll-Like Receptor 9ConceptsAsthmatic miceExperimental asthmaDendritic cellsTherapeutic effectDay 28Live A. fumigatus conidiaControl dendritic cellsMucus cell metaplasiaKey pathological featureCell-associated receptorsA. fumigatus conidiaProtein expression levelsAirway hyperresponsivenessCXCL9 levelsFungal asthmaPeribronchial fibrosisAsthma modelIL-12p70Time-dependent mannerAllergic inflammationAsthma severityCell metaplasiaIL-33Therapeutic blockadeC57BL/6 mice
2006
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death. Nature Medicine 2006, 12: 1286-1293. PMID: 17086189, PMCID: PMC2768268, DOI: 10.1038/nm1494.Peer-Reviewed Original ResearchConceptsAcute lung injuryHyperoxic acute lung injuryLung injuryPulmonary edemaEpithelial necrosisAlveolar edema fluidSiRNA-treated miceCell deathLung epithelial cellsEndothelial cell apoptosisBronchopulmonary dysplasiaVascular leakAngiopoietin-2Edema fluidOxidant injuryAng2 expressionHyperoxiaAng2Vascular regressionBlood vesselsCell apoptosisInjuryNecrotic cell deathEpithelial cellsCell death pathwaysTransgenic Modeling of Transforming Growth Factor-β1
Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA. Transgenic Modeling of Transforming Growth Factor-β1. Annals Of The American Thoracic Society 2006, 3: 418-423. PMID: 16799085, PMCID: PMC2658706, DOI: 10.1513/pats.200602-017aw.Peer-Reviewed Original ResearchConceptsTissue fibrosisMucus metaplasiaIL-13Alveolar remodelingSpecific chemokine receptorsTransforming Growth Factor-β1Vascular endothelial growth factorGrowth factor-β1Endothelial growth factorEosinophilic inflammationTh2 responsesVascular responsesChemokine receptorsCC chemokinesPathologic fibrosisMurine lungEpithelial apoptosisFactor-β1Transgenic miceFibrosisPotent stimulatorAdenosine metabolismIL-11Transgenic modelingInflammation
2004
Asthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.BooksConceptsIL-13Key effector cytokineAnti-inflammatory therapyIL-13 productionProduction of chemokinesProgression of diseaseAirway fibrosisAllergic asthmaAirway remodelingEffector cytokinesEosinophilic inflammationPersistent diseaseTh2 cytokinesEpithelial damageDisease progressionInflammatory responseTh2 cellsMucus productionSmooth muscleBronchial airwaysMatrix metalloproteinasesAnimal dataAsthmaDisease persistenceInflammation
2000
Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks
O'Regan A, Nau G, Chupp G, Berman J. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Trends In Immunology 2000, 21: 475-478. PMID: 11071524, DOI: 10.1016/s0167-5699(00)01715-1.Peer-Reviewed Original ResearchIL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
Corne J, Chupp G, Lee C, Homer R, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman A, Elias J. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. Journal Of Clinical Investigation 2000, 106: 783-791. PMID: 10995789, PMCID: PMC381393, DOI: 10.1172/jci9674.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBlotting, WesternBronchoalveolar Lavage FluidEndothelial Growth FactorsEpithelial CellsFibroblast Growth Factor 10Fibroblast Growth Factor 7Fibroblast Growth FactorsGene Expression RegulationGrowth SubstancesHyperoxiaImmunohistochemistryInterleukin-13LungLymphokinesMacrophagesMiceMice, TransgenicMuscle, SmoothOxygenProtein IsoformsSurvival RateVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAcute lung injuryHyperoxic acute lung injuryIL-13Lung injuryVEGF accumulationProtective effectTransgenic miceRoom airNontransgenic littermate controlsBreathing room airAcid isoformEndothelial cell growth factorVascular endothelial cell growth factorMice breathing room airCell growth factorBronchoalveolar lavageNontransgenic miceLittermate controlsImportant causeAntibody neutralizationMiceGrowth factorInjuryHyperoxiaSurvival
1999
Airway remodeling in asthma
Elias J, Zhu Z, Chupp G, Homer R. Airway remodeling in asthma. Journal Of Clinical Investigation 1999, 104: 1001-1006. PMID: 10525034, PMCID: PMC408860, DOI: 10.1172/jci8124.Peer-Reviewed Original ResearchAttenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Nau G, Liaw L, Chupp G, Berman J, Hogan B, Young R. Attenuated Host Resistance againstMycobacterium bovis BCG Infection in Mice Lacking Osteopontin. Infection And Immunity 1999, 67: 4223-4230. PMID: 10417195, PMCID: PMC96728, DOI: 10.1128/iai.67.8.4223-4230.1999.Peer-Reviewed Original ResearchConceptsOPN-null miceMycobacterial infectionAntigen-specific T-cell immunityMycobacterium bovis BCG infectionBacterial loadClearance of mycobacteriaT cell immunityGamma interferon productionWild-type miceNitric oxide productionMediators of resistanceAbility of osteopontinElevated bacterial loadHeavy bacterial loadMycobacterium bovis BCGBCG infectionSevere infectionsHost protectionMouse modelMacrophage defectHost responseInterferon productionCytokine osteopontinOxide productionInfection
1996
Biological activity of interleukin-16
Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature 1996, 382: 501-502. PMID: 8700223, DOI: 10.1038/382501b0.Peer-Reviewed Original Research