2020
The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine
Farnum SO, Makarenko I, Madden L, Mazhnaya A, Marcus R, Prokhorova T, Bojko MJ, Rozanova J, Dvoriak S, Islam Z, Altice FL. The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine. Addiction 2020, 116: 83-93. PMID: 32428276, PMCID: PMC7674222, DOI: 10.1111/add.15115.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOAT discontinuationAgonist therapyTreatment retentionIndependent predictorsHIV epidemicCost-effective HIV prevention strategyMethadone maintenance treatment patientsObservational longitudinal cohort studySpecialty addictions treatmentBuprenorphine maintenance treatmentHigh dosageHIV prevention strategiesLongitudinal cohort studyOpioid-dependent peopleTreatment discontinuationCohort studyMaintenance treatmentMale sexTreatment patientsPrevention strategiesDiscontinuationYounger ageCenter settingAddiction treatment
2018
Drug injection within prison in Kyrgyzstan: elevated HIV risk and implications for scaling up opioid agonist treatments
Azbel L, Wegman MP, Polonsky M, Bachireddy C, Meyer J, Shumskaya N, Kurmanalieva A, Dvoryak S, Altice FL. Drug injection within prison in Kyrgyzstan: elevated HIV risk and implications for scaling up opioid agonist treatments. International Journal Of Prisoner Health 2018, 14: 175-187. PMID: 30274558, PMCID: PMC6447033, DOI: 10.1108/ijph-03-2017-0016.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentNeedle syringe programsDrug injectionDrug injectorsHigh HIV risk behaviorElevated HIV riskPrison drug injectionHepatitis C infectionOpioid agonist treatmentHIV risk behaviorsC infectionHIV incidenceAgonist treatmentMaintenance treatmentIndependent correlatesBiobehavioral surveysHIV riskOnly examinationRisk behaviorsMMT useLow uptakeCurrent incarcerationInjectionLogit linkHigh-risk environmentsPrisoner health status at three rural Haitian prisons
LaMonaca K, Desai M, May JP, Lyon E, Altice FL. Prisoner health status at three rural Haitian prisons. International Journal Of Prisoner Health 2018, 14: 197-209. PMID: 30274560, DOI: 10.1108/ijph-02-2017-0010.Peer-Reviewed Original ResearchConceptsBody mass indexHealth statusPhysical functionSociodemographic characteristicsSelf-reported physical functionBetter overall health statusHigher body mass indexPrisoners' health statusOverall health statusCross-sectional studyPhysical health statusMental health statusPoor health outcomesSelf-rated healthLength of detentionAdequate medical careMass indexFood insecurityHealth outcomesAdequate nutritionMedical carePrisoner healthRegional prisonsLow-income countriesMental healthExtended-Release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living With HIV With Opioid Use Disorders Transitioning to the Community
Springer SA, Di Paola A, Azar M, Barbour R, Biondi BE, Desabrais M, Lincoln T, Skiest DJ, Altice FL. Extended-Release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living With HIV With Opioid Use Disorders Transitioning to the Community. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 78: 43-53. PMID: 29373393, PMCID: PMC5889326, DOI: 10.1097/qai.0000000000001634.Peer-Reviewed Original ResearchMeSH KeywordsAdultCriminal LawDelayed-Action PreparationsDouble-Blind MethodFemaleFollow-Up StudiesHIV InfectionsHIV-1HumansInjections, IntramuscularMaleMiddle AgedMultivariate AnalysisNaltrexoneNarcotic AntagonistsOpioid-Related DisordersPrisonersProspective StudiesResearch DesignRNA, ViralTime FactorsTreatment OutcomeViral LoadConceptsOpioid use disorderViral suppressionXR-NTXPlacebo groupPrimary outcomeUse disordersXR-NTX groupPlacebo-controlled trialExtended-release naltrexoneStatistical significant differenceRelease naltrexoneMonthly injectionsEligible participantsTreatment groupsJail detaineesHIVMonthsBaselinePlaceboSignificant differencesNaltrexoneJail inmatesDisordersVS levelsOutcomes
2017
Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study
Zelenev A, Li J, Mazhnaya A, Basu S, Altice FL. Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study. The Lancet Infectious Diseases 2017, 18: 215-224. PMID: 29153265, PMCID: PMC5860640, DOI: 10.1016/s1473-3099(17)30676-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntiviral AgentsChemopreventionCitiesComputer SimulationDisease Transmission, InfectiousFemaleHepatitis CHumansMaleMiddle AgedModels, StatisticalPrevalenceSubstance Abuse, IntravenousSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsBaseline HCV prevalenceHepatitis C virusHCV prevalenceInjection partnersPrevention strategiesTreatment coverageTransmission of HCVHepatitis C virus (HCV) treatmentHCV elimination strategySuccessful HCV treatmentC virus treatmentInjection drug usersHCV treatment coverageAdditional network memberHCV treatmentActing antiviralsC virusChronic infectionVirus treatmentDrug usersPrevalenceDrug abuseDrugsNational InstitutePrevention
2015
Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates.
Meyer JP, Cepeda J, Taxman FS, Altice FL. Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates. American Journal Of Public Health 2015, 105: 1901-10. PMID: 26180958, PMCID: PMC4529767, DOI: 10.2105/ajph.2015.302687.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyViral suppressionSex-related differencesHigh prevalenceRisk scoreHIV treatment outcomesRetrospective cohort studyHIV viral suppressionLarge contemporary cohortSex-related disparitiesSex-specific interventionsCommunity-based treatmentWomen's higher prevalenceLogistic regression modelsCJ populationsTreatable comorbiditiesCohort studyHIV outcomesContemporary cohortTreatment outcomesHIVCJ involvementIncarceration durationOlder ageSignificant correlates
2014
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community
Di Paola A, Lincoln T, Skiest DJ, Desabrais M, Altice FL, Springer SA. Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community. Contemporary Clinical Trials 2014, 39: 256-268. PMID: 25240704, PMCID: PMC4283549, DOI: 10.1016/j.cct.2014.09.002.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentPlacebo-controlled trialXR-NTXAgonist treatmentOpioid dependenceTreatment outcomesPoor HIV treatment outcomesOpioid treatment outcomesOpioid-dependent prisonersExtended-release naltrexoneHIV treatment outcomesHIV transmission riskEvidence-based treatmentsCriminal justice settingsEarly acceptabilityStudy medicationFirst injectionStudy acceptabilityHIVTotal referralsJail detaineesCommunity settingsTransmission riskDrug relapseHigh internal validity
2013
Partner violence and health among HIV-infected jail detainees
Meyer JP, Wickersham JA, Fu JJ, Brown SE, Sullivan TP, Springer SA, Altice FL. Partner violence and health among HIV-infected jail detainees. International Journal Of Prisoner Health 2013, 9: 124-141. PMID: 24376468, PMCID: PMC3873166, DOI: 10.1108/ijph-03-2013-0011.Peer-Reviewed Original ResearchConceptsIntimate partner violenceSubstance use disordersHIV treatment outcomesHealthcare utilizationPartner violenceTreatment outcomesJail detaineesIPV exposureEffects of IPVHIV secondary preventionPost-release interventionsUntreated mental disordersDepth qualitative interviewsLifetime IPV exposureForms of childhoodHigher alcohol use severityCriminal justice populationsAlcohol use severityViolence reductionCJ populationsTime of incarcerationHIV diagnosisSecondary preventionAdulthood abuseQualitative interviewsMethadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine
Morozova O, Dvoryak S, Altice FL. Methadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine. International Journal Of Drug Policy 2013, 24: e91-e98. PMID: 24360402, PMCID: PMC5553122, DOI: 10.1016/j.drugpo.2013.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAntitubercular AgentsDelivery of Health Care, IntegratedDrug UsersFemaleHealth Knowledge, Attitudes, PracticeHeroin DependenceHumansInpatientsMaleMedication AdherenceMethadoneOpiate Substitution TreatmentProspective StudiesRisk FactorsTime FactorsTreatment OutcomeTuberculosisUkraineConceptsTB medication adherenceMethadone maintenanceTB treatmentMedication adherenceTreatment discontinuationMulti-drug resistant tuberculosisInpatient TB treatmentNumerous treatment challengesTB treatment completionOnly independent predictorOpioid-dependent patientsIndependent predictorsPrimary outcomeOpioid dependenceResistant tuberculosisMethadone treatmentTB facilitiesTreatment optionsDependent patientsTuberculosis treatmentTreatment completionTreatment challengesObservational studyMMT groupTreatment retention
2012
Retention on buprenorphine treatment reduces emergency department utilization, but not hospitalization, among treatment-seeking patients with opioid dependence
Schwarz R, Zelenev A, Bruce RD, Altice FL. Retention on buprenorphine treatment reduces emergency department utilization, but not hospitalization, among treatment-seeking patients with opioid dependence. Journal Of Substance Use And Addiction Treatment 2012, 43: 451-457. PMID: 22534003, PMCID: PMC3419304, DOI: 10.1016/j.jsat.2012.03.008.Peer-Reviewed Original ResearchConceptsBuprenorphine maintenance treatmentHealthcare utilizationED utilizationEmergency department usageOpioid-dependent patientsEmergency department utilizationLate-stage diseaseTreatment-seeking patientsBuprenorphine treatmentChart reviewPerson yearsED useMaintenance treatmentOpioid dependenceDependent patientsPrimary careHospitalizationDrug usersNegative binomial regressionBinomial regressionPatientsComparison of timeTreatmentAverage lengthStay
2011
Attitudes toward opioid substitution therapy and pre-incarceration HIV transmission behaviors among HIV-infected prisoners in Malaysia: Implications for secondary prevention
Bachireddy C, Bazazi AR, Kavasery R, Govindasamy S, Kamarulzaman A, Altice FL. Attitudes toward opioid substitution therapy and pre-incarceration HIV transmission behaviors among HIV-infected prisoners in Malaysia: Implications for secondary prevention. Drug And Alcohol Dependence 2011, 116: 151-157. PMID: 21232882, PMCID: PMC3084892, DOI: 10.1016/j.drugalcdep.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitudeComorbidityHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMalaysiaMaleMiddle AgedNeedle SharingOpiate Substitution TreatmentOpioid-Related DisordersPrisonersPrisonsRisk-TakingSecondary PreventionSexual BehaviorSubstance Abuse, IntravenousTime FactorsUnsafe SexYoung AdultConceptsOpioid substitution therapyHIV transmission behaviorsSubstitution therapyUnprotected sexSecondary HIV prevention effortsCommunity HIV transmissionInjection of buprenorphineSecondary HIV preventionInjection drug useHIV prevention effortsSterile injection equipmentOpioid injectionSecondary preventionOpioid dependenceHIV transmissionHIV preventionMale prisonersHIV riskInjection riskDrug useHIVCareful monitoringSexual riskBehavioral interventionsPrevention efforts
2010
Testing for HIV, Sexually Transmitted Infections, and Viral Hepatitis in Jails: Still a Missed Opportunity for Public Health and HIV Prevention
Flanigan TP, Zaller N, Beckwith CG, Bazerman LB, Rana A, Gardner A, Wohl DA, Altice FL. Testing for HIV, Sexually Transmitted Infections, and Viral Hepatitis in Jails: Still a Missed Opportunity for Public Health and HIV Prevention. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 55: s78-s83. PMID: 21406992, DOI: 10.1097/qai.0b013e3181fbc94f.Peer-Reviewed Original ResearchConceptsPublic health opportunityHIV preventionInfectious diseasesViral hepatitisHIV testingJail-based screeningHealth opportunitiesHigh-risk communitiesSTI diagnosisHIV infectionSTI testingCommunity prevalenceHigh riskHIVCommunity careInfectionPreventionDiseaseHepatitisTreatmentPublic healthIncarcerated individualsVast majorityPersons of colorTestingPsychiatric and Substance Abuse Comorbidity among HIV Seropositive and HIV Seronegative Prisoners in Malaysia
Zahari MM, Bae W, Zainal NZ, Habil H, Kamarulzaman A, Altice FL. Psychiatric and Substance Abuse Comorbidity among HIV Seropositive and HIV Seronegative Prisoners in Malaysia. The American Journal Of Drug And Alcohol Abuse 2010, 36: 31-38. PMID: 20141394, PMCID: PMC4847714, DOI: 10.3109/00952990903544828.Peer-Reviewed Original ResearchConceptsHIV infectionSubstance abusePsychiatric illnessPsychiatric disordersTriple diagnosisPsychiatric diagnosisDrug useMental illnessSubstance abuse comorbidityInjection drug useCross-sectional studyStructured Clinical InterviewSubstance use disordersPublic health approachMental Disorders-IVHIV-seropositiveOpioid dependencePotential confoundersDiagnostic Statistical ManualUse disordersDual diagnosisClinical InterviewAdequate careCommunity settingsHealth approach
2009
A Prospective Controlled Trial of Routine Opt-Out HIV Testing in a Men's Jail
Kavasery R, Maru DS, Sylla LN, Smith D, Altice FL. A Prospective Controlled Trial of Routine Opt-Out HIV Testing in a Men's Jail. PLOS ONE 2009, 4: e8056. PMID: 19946371, PMCID: PMC2777336, DOI: 10.1371/journal.pone.0008056.Peer-Reviewed Original ResearchConceptsRoutine optHIV testingProspective Controlled TrialTesting groupMen's jailProportion of menPreliminary positive resultsPrimary outcomeControlled TrialsJail detaineesMultivariate analysisDisease controlHIVLower likelihoodWeek periodHigh ratePositive resultsTrialsGroupMale inmatesNew HavenOptimal timeJailEarly releaseTestingRoutine Opt-Out HIV Testing Strategies in a Female Jail Setting: A Prospective Controlled Trial
Kavasery R, Maru DS, Cornman-Homonoff J, Sylla LN, Smith D, Altice FL. Routine Opt-Out HIV Testing Strategies in a Female Jail Setting: A Prospective Controlled Trial. PLOS ONE 2009, 4: e7648. PMID: 19946370, PMCID: PMC2777332, DOI: 10.1371/journal.pone.0007648.Peer-Reviewed Original ResearchConceptsRoutine optHIV testingJail settingsNew CDC guidelinesHIV testing strategiesProspective Controlled TrialLow testing ratesProportion of womenControlled TrialsPrimary outcomeCDC guidelinesHigh prevalenceTesting ratesJail detaineesYounger ageLower likelihoodHIVWeek periodHigh rateTesting groupTrialsWomenTesting strategiesFemale inmatesGroup
2002
The Impact of Needle Exchange–based Health Services on Emergency Department Use
Pollack HA, Khoshnood K, Blankenship KM, Altice FL. The Impact of Needle Exchange–based Health Services on Emergency Department Use. Journal Of General Internal Medicine 2002, 17: 341-348. PMID: 12047730, PMCID: PMC1495047, DOI: 10.1046/j.1525-1497.2002.10663.x.Peer-Reviewed Original ResearchConceptsInjection drug usersTreatment injection drug usersEmergency department useIncidence rate ratiosED utilizationED useDepartment useDrug usersHigh-risk injection drug usersHIV-negative injection drug usersMobile health clinicHealth care delivery systemHealth care servicesCare delivery systemHIV/AIDSPre-post comparisonAcute careEmergency departmentSubgroup analysisMedical recordsHealth clinicsLongitudinal cohortDrug treatmentED servicesBinomial regression analysis