Lloyd G. Cantley, MD

Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury.

Dr. Cantley’s laboratory has on-going NIH R01 support for research in kidney disease since 1995, focusing on the growth factor signaling and cellular response pathways involved in kidney tubule formation, injury and repair. Dr. Cantley’s laboratory has long-standing expertise in defining intracellular signaling pathways that regulate cell activation states as well as the use of murine models of acute kidney injury. During the past 15 years his lab has investigated the role of the immune system in regulating tubular cell signaling, leading to the investigations of macrophage function in response to injury, repair and cystogenesis. His lab has found that macrophages are critical regulators of both initial injury and subsequent repair, and that cross-talk between macrophages and surviving tubular cells determines the macrophage expression profile that induces tubule repair. Dr. Cantley’s lab has also identified activation of the phosphoinositide 3-kinase and MAPK pathways as critical regulators of epithelial cell migration and morphogenesis during both development and repair. Dr. Cantley’s lab has had ongoing NIH R01 support for this research since 1995.

Dr. Cantley was a PI On the Yale Nephrology T32 training grant, where 45 trainees have worked on their research in his laboratory, many of which have moved on to academic research positions, or leadership positions in the research divisions of major Pharmaceutical companies.