In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
When Cells Cycle Fast, Cancer Gets a Jumpstart
The progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions to genes that confer risk of cancer accumulate and alter normal cell behaviors, giving rise, scientists believe, to early stage cancer cells that eventually swamp normal cells and become deadly.
Yale Scientists Win NIH Awards for Pioneering Work
Yale School of Medicine’s Valentina Greco and Marina R. Picciotto are among the 11 recipients of the National Institutes of Health’s Pioneer Award, which recognizes scientists who have a history of creative research and who show promise in originating “pioneering approaches to major challenges.” Greco and Picciotto will each receive $3.5 million dollars of funding over the course of five years. In addition, four young Yale scientists will receive the NIH’s Innovator Award.
Colón-Ramos Awarded Landis Mentoring Award
Daniel A. Colón-Ramos, PhD, associate professor of neuroscience and cell biology, has been selected for the Landis Award for Outstanding Mentorship, a new annual award from the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH).
Function of gene mutations linked to neurological diseases identified
Several gene mutations have been linked to Parkinson’s disease, but exactly how and where some of them cause their damage has been unclear. A new Yale study, published in The Journal of Cell Biology, shows that one of the genes whose mutations are responsible for a familial form of Parkinson’s encodes a protein that controls the transfer of lipids between membranes of cell organelles.
Action of ‘molecular bouncers’ captured at model of nuclear membrane
DNA is packaged tightly within the cell’s nuclear membranes, which contain channels that regulate the transit of macromolecules governing all of life’s functions. Yale University researchers have built a nanoscale replica of this channel and have visualized the interaction of proteins that act as “molecular bouncers,” controlling access to the channel’s 40-nanometer entrance.
Unlocking the promise of stem cells
Haifan Lin has been a leader in stem cell research since its infancy. In just over a decade since he arrived at Yale to found the university’s Stem Cell Center, the center has grown from just a pair of labs to more than 40. Lin and his team are closing in on what they hope will be major breakthroughs in the clinical application of stem cells.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Dr. Fred Gorelick designated the Binder Professor of Internal Medicine
Dr. Fred Sanford Gorelick, newly designated as the Henry J. and Joan W. Binder Professor of Internal Medicine, focuses his research on the mechanisms that initiate pancreatitis, a severe inflammatory disease that causes death in up to 5% of patients.
Looking Beyond the Individual: Reflections on E.E. Just and How Academic Institutions Shape Scientific Careers
This President’s Column is by guest columnist Daniel Colón-Ramos, recipient of the 2016 E.E. Just Award from the ASCB and associate professor of Cell Biology and Neuroscience at Yale University.
James Rothman appointed Sterling Professor of Cell Biology
James E. Rothman, newly appointed as a Sterling Professor of Cell Biology, is one of the world's most distinguished biochemists and cell biologists. For his work on how molecular messages are transmitted inside and outside of human cells, he was awarded a Nobel Prize in 2013.
Six faculty elected to Connecticut Academy of Science and Engineering
Six Yale School of Medicine researchers have been elected to the prestigious Connecticut Academy of Science and Engineering (CASE), including: Alison P. Galvani, Jonathon Howard, Ann Kurth, Frederick J. Sigworth, Hugh S. Taylor, and Sandra Wolin.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.