Julia von Blume Receives Innovative Science Accelerator Award
The ISAC award provides seed funding for exceptionally innovative, disruptive (high-risk/high-reward) research relevant to the NIDDK Division of Kidney, Urologic, & Hematologic Diseases that has the potential to lead to groundbreaking or paradigm-shifting results that will change the field. The von Blume lab investigates how neutrophils, frontline defenders against infections, are armed with proteins in distinct granule types. Regulated exocytosis activates them for chemotaxis, phagocytosis, and bacteria eradication. Yet, the molecular mechanisms of granule formation are unclear, limiting treatments for neutropenic disorders. The von Blume lab will investigate molecular mechanisms of neutrophil granule biogenesis that could pave the way for powerful therapeutic strategies. This project will be performed in collaboration with Shangqin Guo’s Yale Stem Cell Center lab.Source: ISAC AWARD PROGRAM, NIDDK Division of Kidney, Urologic, & Hematologic Diseases
Yale researchers visualize “ultra-slow” axonal transport in a living organism
In a new study published in Developmental Cell, a team of Yale researchers developed a new method to visualize spectrin, an essential component of an axon’s cytoskeleton, and uncovered two spectrin transport speeds – one slow, one ultra-slow.
Supersize the Cell: Unlocking Secrets of the Genome Through Expansion Microscopy
Investigators have developed a technique that makes microscopic specimens 4,000 times larger, letting researchers see fundamental genomic processes that previously were too small to visualize and evaluate hypotheses that until recently were untestable.
Chemical ‘Supercharger’ Solves Molecular Membrane Mystery
Assemblies of tiny molecular proteins span the membranes that encapsulate our cells, directing cellular activities and regulating the transport of materials and information in and out. Scientists at the Yale Nanobiology Institute have decoded a chemical signal that allows them to capture these biological interactions directly from their natural habitat.Source: Yale West Campus
Meet Our Speakers: Brian Chait
Dr. Brian Chait, the Camille and Henry Dreyfus Professor, at Rockefeller University, will be visiting Yale to give a talk entitled “On Methods for Probing the Protein Interactions” on May 9, 2023. His lab focuses on developing tools, centering around mass spectrometry approaches to study the structure and function of biomolecular assemblies. Caroline Brown had the pleasure of chatting with him prior to his visit to Yale to find out about his personal and scientific journey.
Dr. Michael Nathanson Receives AASLD Distinguished Service Award
Michael Nathanson, MD, PhD, Gladys Crofoot Professor of Medicine (Digestive Diseases) and professor of cell biology, received the 2022 Distinguished Service Award from the American Association for the Study of Liver Disease (AASLD) during its annual meeting on November 5.
Lin and Greco Take Office as Leaders of Stem Cell Society
Two of Yale’s stem cell faculty— Haifan Lin, PhD, and Valentina Greco, PhD— are serving in the highest ranks of the International Society for Stem Cell Research (ISSCR). ISSCR is a global organization with more than 4,400 members from 70 countries.