When Cells Cycle Fast, Cancer Gets a Jumpstart
The progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions to genes that confer risk of cancer accumulate and alter normal cell behaviors, giving rise, scientists believe, to early stage cancer cells that eventually swamp normal cells and become deadly.
Deadlier Colon Cancer Develops Differently in Women and Men
WHRY-affiliated researchers have found that colon cancer tumor cells produce energy for growth differently in women and men, and that this difference is associated with a more aggressive form of tumor growth with a higher incidence in women.
Dr. Mehra Golshan Appointed Deputy Chief Medical Officer for Surgical Services at Smilow Cancer Hospital and Yale Cancer Center
Mehra Golshan, M.D., M.B.A., F.A.C.S., has been appointed the inaugural Deputy Chief Medical Officer for Surgical Services at Smilow Cancer Hospital and Yale Cancer Center, Professor of Surgery at Yale School of Medicine, and Interim Director of the Breast Center at Smilow Cancer Hospital.
Throat Cancers Are on the Rise: Why This Matters to You
These cancers are on the rise among men, and HPV is causing the uptick. The Centers for Disease Control and Prevention (CDC) estimates that 79 million Americans are infected with HPV and that 90% of men and 80% of women will be infected with the virus at some point in their lives.
Humanized Mice Lead to Breakthroughs in Blood Cancers
Humanized mice created at Yale are opening new avenues of research into cancers caused by disorders in the production of blood, such as acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Until recently, such research was hindered because human blood stem cells are difficult to grow in cell cultures or to engraft in mice.
Dark Chemical Matter and Colon Cancer
Seven years ago, Jason Crawford, PhD, began chasing a ghost: A bacterial toxin named colibactin. He was looking for its molecular structure. He could detect bits of it, but never enough to form an entire likeness. Four years into the hunt he asked Seth Herzon, PhD, to join him. They pursued colibactin so doggedly because it is associated with up to 67 percent of all colon cancers.
The Microbiome and Cancer Treatment
Andrew Goodman, PhD, studies the abundant flora in the gut, but he initially trained in ecology and sees many parallels. He thinks of the microbiome as an ecosystem and the members of the ecosystem as bacteria. His recent research reveals that microbes are dynamic agents that should be considered in medical care.
Cancer and Obesity: The Link is Insulin
Nearly 40 percent of Americans over the age of 20 are obese, and another 32 percent are overweight. These alarming figures grow darker when combined with statistics showing that obesity is second only to smoking as a cause of preventable cancer deaths. Obesity has been linked to more than a dozen types of cancer.
From Paradox to Breakthrough
Aaron Ring, MD, PhD, was hooked by a paradox. He had been studying cytokines to understand their potential to stimulate anti-tumor immunity. Though cytokines, such as interleukin-2, have been in clinical use for decades, they have historically shown only limited effectiveness. Dr. Ring was hunting for interleukins that could deliver a specific signal to activate TILs.
Ten Years of Leadership in Immunotherapy
The last several years have been packed with revolutionary developments in immunotherapy, the decade’s biggest breakthrough in cancer treatment. Yale scientists have played leading roles in that story. Despite the tremendous progress, big challenges remain.
Scientists find many gene 'drivers' of cancer, but warn: Don't ignore 'passengers'
A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as “drivers” — variations in DNA sequences that lead to the development of cancer.
Kunz Named Leader of Gastrointestinal Cancers Program at Smilow Cancer Hospital and Yale Cancer Center
Pamela L. Kunz, M.D., has been appointed Leader of the Gastrointestinal Cancers Program at Smilow Cancer Hospital at Yale New Haven and Yale Cancer Center and Director of GI Medical Oncology within the Section of Medical Oncology.
Yale Cancer Center Awards for Clinical Excellence presented during annual Conclave
Debra Brandt, D.O. and Kevin Kim, M.D. were each honored with the Yale Cancer Center (YCC) Award for Clinical Excellence at YCC’s annual Conclave on Monday, January 13. The night celebrated the accomplishments of goals set for 2019 and honored faculty and staff with clinical and research prizes.