In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
A precise architecture, maintained as neurons grow
Nerve cells make their connections at junctions called synapses, following a precise architecture that is mostly laid out early in development. But how do the synapses maintain their correct positions as the animal grows? Yale scientists have produced the first evidence that this process relies on glial cells and identified a novel molecular pathway that could be linked in humans to neurological disease.
Yale researchers trick bacteria to deliver a safer vaccine
Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues but Yale researchers have developed a new trick to circumvent the problem — using bacteria’s own cellular mistakes to deliver a safe vaccine.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Yale biologist peers into inner working of the cell
Daniel Colón-Ramos, assistant professor of cell biology, studies the C. elegans nematode, and uses the latest microscopy technology to watch neurons locate a target and form precise synaptic connections, resulting in the neural circuits that underlie human behavior. In this talk at a TEDx event in San Juan in November 2011, Colón-Ramos discusses "The Value of Basic Research in Medicine."Source: Yale News
Le Zhang, PhD Wins Avenir Award for Research on Substance Use Disorders and HIV/AIDS
Assistant Professor Le Zhang, PhD was recently awarded a DP2 grant from the National Institutes of Health (NIH), entitled “Immune Network Dysregulation of the Central Nervous System with HIV Persistence and Opioid Abuse.” The grant, which amounts to more than $2.5 million, began on May 15, 2022 and lasts for four years.
Sex Differences in the Acute Effects of Intravenous (IV) Delta‑9 Tetrahydrocannabinol (THC)
Anahita Bassir Nia, MD, assistant professor of psychiatry, and Mohini Ranganathan, MD, associate professor of psychiatry, are first and senior authors, respectively, of a paper in Psychopharmacology that investigated the sex differences in the acute effects of intravenous (IV) delta 9 tetrahydrocannabinol (THC), the main psychoactive compound of cannabis.Source: Psychopharmacology
Sticky Nanoparticles Fight Skin Cancer
Using bioadhesive nanoparticles from the laboratory of Dr. W. Mark Saltzman, Dr. Michael Girardi and his team collaborated with Dr. Saltzman and loaded them with a one-two punch of chemotherapy plus immunotherapy to study its impact in skin cancer. The results may have significant impact for how skin cancer tumors are treated.