In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
A precise architecture, maintained as neurons grow
Nerve cells make their connections at junctions called synapses, following a precise architecture that is mostly laid out early in development. But how do the synapses maintain their correct positions as the animal grows? Yale scientists have produced the first evidence that this process relies on glial cells and identified a novel molecular pathway that could be linked in humans to neurological disease.
Yale researchers trick bacteria to deliver a safer vaccine
Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues but Yale researchers have developed a new trick to circumvent the problem — using bacteria’s own cellular mistakes to deliver a safe vaccine.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Yale biologist peers into inner working of the cell
Daniel Colón-Ramos, assistant professor of cell biology, studies the C. elegans nematode, and uses the latest microscopy technology to watch neurons locate a target and form precise synaptic connections, resulting in the neural circuits that underlie human behavior. In this talk at a TEDx event in San Juan in November 2011, Colón-Ramos discusses "The Value of Basic Research in Medicine."
Yale Researchers Find Where Stress Lives
Yale researchers have found a neural home of the feeling of stress people experience, an insight that may help people deal with the debilitating sense of fear and anxiety that stress can evoke, Yale researchers report May 27 in the journal Nature Communications.
Updates in Consultation-Liaison Psychiatry: 2019
Paula Zimbrean, MD, Associate Professor of Psychiatry; Walter Luchsinger, MD, Addiction Psychiatry Fellow; and Jordan Rosen, MD, Consultation-Liaison Psychiatry Fellow, are co-authors of a paper published in Psychosomatics that identifies the 10 most important manuscripts for clinical practice in consultation-liaison psychiatry from 2019.
Courses of Suicidal Ideation Among Military Veterans in Residential Treatment for Posttraumatic Stress Disorder
Noelle B. Smith, PhD, Assistant Clinical Professor of Psychiatry; Rani Hoff, PhD, Professor of Psychiatry; and Ilan Harpaz-Rotem, PhD, are co-authors of a study published in Depression & Anxiety that examines the prevalence and correlates of four courses of suicidal ideation among veterans receiving residential treatment for posttraumatic stress disorder.
Psilocybin-Assisted Therapy of Major Depressive Disorder Using Acceptance and Commitment Therapy as a Therapeutic Frame
Jordan Sloshower, MD, MSc, Research Fellow in Addiction Psychiatry, is the first author of a paper published in Journal of Contextual Behavioral Science that tracks the psychedelic assisted therapy of depression with the integration of Acceptance and Commitment Therapy.
Delayed Homelessness After Military Discharge: Examination of a Sleeper Effect
Jack Tsai, PhD, Adjunct Associate Professor of Psychiatry, and Robert Pietrzak, PhD, Associate Professor of Psychiatry and Public Health, are the first and senior authors, respectively, published in American Journal of Preventive Medicine that examines the “sleeper effect” of longer discharge-to-homelessness periods for veterans including service in the Vietnam War, younger age at military discharge, and chronic medical conditions, depression, and alcohol use problems.
Ni Feng receives a 2020 Warren Alpert Distinguished Scholar Award
Ni Fend, a postdoctoral researcher in Elena Gracheva's lab, has become a 2020 Warren Alpert Distinguished Scholar. Her project "Hanging in the Balance: Fluid Homeostasis in Hibernation" aims to reveal fundamental knowledge about how hibernation enables some species to survive over an entire winter without water. This project will use the thirteen-lined ground squirrel as a model system to dissect and manipulate the neural circuits that regulate fluid balance across torpor and arousal states during hibernation.
Krystal Co-Author of NEJM Article That Tracks Symptom Improvement in Patients With Schizophrenia
Patients with schizophrenia demonstrated improvement on a scale used to measure symptom severity after taking a drug being tested in a clinical trial, according to an article published online in the New England Journal of Medicine and co-authored by John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and Chair of the Yale Department of Psychiatry at Yale School of Medicine
Further Guidance for Researchers
In follow-up to recent communications from President Salovey, Provost Strobel, and me, basic science chairs and directors convened today to discuss the meaning of critical or essential work in the laboratory setting. As the situation on-the-ground around COVID evolves, so must our definition of critical and essential functions in the laboratory.