In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
A precise architecture, maintained as neurons grow
Nerve cells make their connections at junctions called synapses, following a precise architecture that is mostly laid out early in development. But how do the synapses maintain their correct positions as the animal grows? Yale scientists have produced the first evidence that this process relies on glial cells and identified a novel molecular pathway that could be linked in humans to neurological disease.
Yale researchers trick bacteria to deliver a safer vaccine
Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues but Yale researchers have developed a new trick to circumvent the problem — using bacteria’s own cellular mistakes to deliver a safe vaccine.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Yale biologist peers into inner working of the cell
Daniel Colón-Ramos, assistant professor of cell biology, studies the C. elegans nematode, and uses the latest microscopy technology to watch neurons locate a target and form precise synaptic connections, resulting in the neural circuits that underlie human behavior. In this talk at a TEDx event in San Juan in November 2011, Colón-Ramos discusses "The Value of Basic Research in Medicine."Source: Yale News
Implicit Organizational Bias: Mental Health Treatment Culture and Norms as Barriers to Engaging with Diversity
Miraj Desai, PhD, Instructor in Psychiatry, is first author of a paper in American Psychologist that aimed to better understand the sources of barriers to care for Latinx and Asian patient populations by examining shared themes across providers’ descriptions of their encounters.Source: Race, Research & Policy Portal
Largest Genome Study to Date of Anxiety Reveals New Risk Variants and Suggests Possible Biological Mechanisms
Daniel Levey, PhD, Associate Research Scientist in Psychiatry, and Joel Gelernter, MD, Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience, are among the authors of a study relating DNA variations and anxiety disorders which has revealed several previously unidentified locations in the human genome where variations in the sequence tend to occur in people with anxiety, compared with people who don't have anxiety.Source: Brain & Behavior Research Foundation
Are you a female over 50 experiencing stress and sleep difficulties?
If you are a female over 50 and feel overwhelmed or stressed and experience difficulty sleeping, you may be eligible to participate in a free and confidential study that provides talk therapy that may help improve your emotional and cognitive health and also looks at how the brain works with advanced MRI scanning techniques.
Yale Researchers Size up the Mental Health Toll of the Pandemic
While researchers have known about the mental health costs of chronic stress, they say this situation is unique because during the pandemic people have also lost many of the social connections and outlets needed to help manage their stress loads.Source: YaleNews
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Yale Department of Psychiatry and Yale Child Study Center researchers conducted the first randomized placebo-controlled clinical trial of intravenous ketamine in adolescents with depression.Source: American Journal of Psychiatry
Yale, VA Researchers Investigate Eating Disorders in Iraq and Afghanistan War-Era Veterans
Researchers at Yale School of Medicine and the VA Connecticut Healthcare System, in a pair of complementary studies, investigated eating disorders in Iraq and Afghanistan war-era veterans, a group thought to be at high risk for the disorders.
Suicide Risk Jumps Soon After Dementia Diagnosis
Older patients recently diagnosed with dementia are at a significantly increased risk for suicide compared to their peers without dementia. Investigators found that individuals who were diagnosed with dementia had a 54% increased risk for suicide within the first year after diagnosis. The risk was particularly high among those aged 74 years and younger. Timothy Schmutte, PsyD, Assistant Professor of Psychiatry, was the study investigator.Source: Medscape