Xinran Nick Liu, MD, PhD

Research Scientist in Cell Biology; Director CCMI, Bio and Cryo Electron Microscopy Core Facility

Research Organizations

Center for Cellular and Molecular Imaging: Electron Microscopy

Research Summary

My research has been focused on 1) identifying synaptic proteins and its relation to synaptic structural specialization; 2) analyzing and characterizing the synaptic ultrastructural organization in genetically engineered animals; 3) correlating EM finding with electrophysiological recording on the mechanism of synaptic exocytosis and vesicle recycling. Currently we are: 1) developing electron tomography on synapses, this technique makes it possible to examine structural details in the 3D contest. 2) utilizing low-temperature methods to prepare cell and tissue samples aiming to reveal the dynamic events that associate with synaptic transmission or endocytosis.

Extensive Research Description

As one of the core facilities in the Medical School, We offer a wide range of services from conventional and immuno- electron microscopy to electron tomography. Our experienced staff routinely perform sample processing, sectioning and imaging for a set fee. Our facility is open to users who have had prior training in electron microscopy. The training on use of electron microscope and sample preparation is provided on a one-on-one basis throughout the year.

Selected Publications

Full List of PubMed Publications

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Contact Info

Xinran Nick Liu, MD, PhD
Mailing Address
CCMI/Cell BiologyP. O. Box 208002
New Haven, CT 06520-8002

Curriculum Vitae

Electron Microscopy Core Facility