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Frank Li, PhD

Senior Principal Scientist, Global Computational Biology and Digital Sciences

Dr. Frank Li is a Senior Principal Scientist at Department of Global Computational Biology and Digital Sciences, Boehringer Ingelheim, Ridgefield, CT. In this role, he oversees bioinformatics analyses using systems biology approaches to better understand and/or characterize the pathological mechanisms contributing to the onset and progression of autoimmune diseases, including Inflammatory Bowel Disease, Systemic Sclerosis, Idiopathic Pulmonary Fibrosis, etc. His group is using holistic “omics” approaches to facilitate discoveries of novel therapeutic concepts, determination of novel biomarkers, and patient stratification and enrichment supporting clinical drug development. He obtained his Ph.D. from the University of North Carolina at Chapel Hill with his doctoral research focus on the breakdown of immunological tolerance of autoreactive CD4+ T cells in autoimmune Type I diabetes. Then, he continued his postdoctoral studies at Harvard Medical School where he worked in the fields of T cell tolerance attempting to decipher the molecular and cellular mechanisms that control T cell differentiation, and the molecular mechanisms controlling the plasticity of FOXP3+ Treg cells using both canonical immunological and systems biology approaches.