Breast, Phase II
SELECT: A Phase II Adjuvant Trial Evaluating the Impact of Omitting Chemotherapy Based on Patient's Selection for Moderate to High-Anatomical Risk, Low-Genomic Risk, ER-Positive, HER2- Negative Breast Cancer With a Combination Regimen of Ribociclib and Optimized Endocrine Therapy
Volunteers
Health Professionals
What is the purpose of this trial?
This is a Phase II Trial to assess the impact of omitting adjuvant chemotherapy based on patient's selection on treatment persistence of CDK4/6 inhibitor, ribociclib (Kisqali), in a well-defined subgroup of patients with resected estrogen receptor (ER)-positive, HER2-negative, lymph node-positive breast cancer, but whose tumor profiling indicates a less aggressive biological nature (OncotypeDx 21-gene recurrence score RS 0-25).
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Principal Investigator
Sub-Investigators
- Adriana Kahn, MD
- Alessia Donadio, MD
- Anca Bulgaru, MD
- Andrea Brennan, PA
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS, MD
- Avery Marzulla-Dulfer, PA
- Benjamin Newton, MD
- Christina Carretta, APRN
- Claire Aurilio
- Clarice Grens, APRN
- D. Barry Boyd, MD, MS
- Daniel O'Neil, MD, MPH
- Diane Eannotti, APRN
- Elan Gorshein, DO, JD, MPH
- Elizabeth Gaa, APRN
- Emily Kopas, APRN, OCN
- Eric Winer, MD
- Gineesha Abraham, APRN
- Ian Krop, MD, PhD
- Jadwiga Kretowicz, APRN
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- Jose Morales-Marin
- Justin Persico, MD
- Karen Ann Hammond, DNP, APRN, ACNP (BC)
- Karishma Mehra, MBBS
- Katelyn Scott, APRN
- Katherine Harvey, MD, MPH
- Kathleen Fenn, MD
- Kathryn Mason, APRN
- Kayla Martello
- Lajos Pusztai, MD, DPhil
- Larisa Fleysher, APRN
- Laura Sabourin
- Madeline Santiago
- Mariya Rozenblit, MD
- Maryam Lustberg, MD, MPH
- Matthew Austin, MD
- Melissa Gambaccini, APRN, AOCNP, FNP-C
- Michael DiGiovanna, MD, PhD
- Michael Grant, MD
- Michelle Corso, APRN
- Neal Fischbach, MD
- Pawan Karanam, MD
- Rebecca Vanasse-Passas, MD
- Robert Legare, MD
- Sara Anastasio, APRN, RN
- Sarah Carlson, PA
- Sarah Thomen, APRN
- Sarah Elizabeth Schellhorn, MD
- Sharynn Hall, MD, PhD
- Stacey LaRosa, APRN
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy, APRN
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Yvonne Ruddy-Stein, APRN
- Zia Rahman, MD
- Last Updated07/03/2026
- Study IRB#2000038734