Demetrios Braddock, MD, PhD

Demetrios Braddock was born in Tennessee, educated at the University of Chicago, trained at the NIH in Anatomic Pathology and Biophysical Chemistry, and came to Yale in 2004 where he practices hematopathology and heads a laboratory studying pathogenic mechanisms of severe and poorly addressed human diseases. His laboratory focuses on rare diseases of children, and on the design and engineering of novel biologics to modulate disease outcomes.

Work in Dr. Braddock’s laboratory includes the design and validation of an enzyme biologic for a lethal infantile calcification disorder called ‘Generalized Arterial Calcification of Infancy’ (GACI), which has been translated into patients and is now in clinical trials in infants, children, and adults with GACI, ARHR2, PXE, and CKD-MBD (ClinicalTrials.gov: NCT05734196, NCT06046820, NCT04686175, NCT06283589).