Congratulations to the 2015 Leslie H. Warner Postdoctoral Fellowship Award Winners:
Katherine Amato, PhD- Faculty mentors: Katie Politi and Susan Kaech “Mechanisms of response and resistance to immune checkpoint inhibitors in lung adenocarcinoma”
Soo Seok (Steve) Hwang, PhD- Faculty mentor: Richard Flavell “A molecular study of transcription factor Hhex mediated Treg development”
Alice Gaudin, PhD- Faculty mentor: Mark Saltzman “PEGylated Squalenoyl-Gemcitabine nanoparticles for the treatment of glioblastoma”
Lizhen Wu, PhD- Faculty mentor: Qin Yan “The regulation of alternative polyadenylation by JARID1 in breast cancer”
Congratulations to the 2015 ASTRO presenters. The conference this year is being held October 18-21st in San Antonio. View Yale sessions
Gary Kupfer, MD has received a $250,000 Scholar Grant from the Hyundai Hope on Wheels Program. Dr. Kupfer will use the funding to screen the Fanconi anemia pathway to identify synthetic lethality to find targets in tumors mutant in Fanconi genes. He also hopes to identify pathways to target that will result in protection of children's bone marrow who have the Fanconi anemia bone marrow failure syndrome.
September 2015Nominations for The Ruth McCorkle Oncology Advanced Practice Provider award are now being accepted.
Dr. Rogerio Lilenbaum has been appointed to the Board of the National Comprehensive Cancer Network.
Yale Cancer Center has received a supplemental grand to our cancer center support grant to support a Community Health Educator to provide clinical trial education and disparity outreach in the New Haven community. The program will be under the direction of Andrea Silber, MD, Beth Jones, PhD, and Melinda Irwin, PhD.
Doximity.com has ranked The Radiation Oncology Residency Program #13 in the nation for reputation in its annual ranking of residency programs.
The David S. Fischer, MD annual award for outstanding teaching & mentoring of fellows in Medical Oncology was awarded to Michael E. Hurwitz, MD, PhD.
The David S. Fischer, MD annual award for outstanding teaching & mentoring of fellows in Hematology was awarded to Alfred Lee, MD.
The David S. Fischer, MD annual award to a faculty member of Yale Cancer Center and The Veterans Administration Connecticut Cancer Center for outstanding teaching & mentoring of fellows in Medical Oncology & Hematology was awarded to Natalia Neparidze, MD.
The Medical Oncology & Hematology Fellowship Program annual award for Outstanding Fellow in Research was awarded to Mehmet Altan, MD (Medical Oncology) and
Andrew Branagan, MD (Hematology).
The Trustees of the Edward Mallinckrodt, Jr. Foundation have named Valentina Greco, PhD, the 59th Mallinckrodt Scholar, through a competitive competition. Dr. Greco is a member of Yale Cancer Center's Signal Transduction Program. The funding of the grant commences October 1, 2015 and includes a stipend of $100,000 annually for four years. Women's Health Research at Yale announced their Pilot Project funding for 2015, and Yale Cancer Center's Christine J. Ko, MD, Associate Professor of Dermatology and Pathology, has been awarded a grant in collaboration with Yale Cancer Center to study skin cancer. Her research project aims to identify a biological marker to predict the growth rate and recurrence of cutaneous squamous cell carcinoma. Dr. Ko's research team's current target is a mutated gene they believe marks the difference between a slow-growing cancer and a more aggressive one.
Richard Edelson, MD, the Aaron B. and Marguerite Lerner Professor of Dermatology and Chair of the department, received the 2015 Discovery Award during the annual meeting of the Dermatology Foundation on March 21 in San Francisco. The award recognizes an outstanding investigator "whose research accomplishments have greatly impacted the understanding of cutaneous biology, identified a previously unrecognized disease, or developed a revolutionary new therapy."
Evan Morris, PhD, a member of Yale Cancer Center's Radiobiology and Radiotherapy Program, has been awarded a Fulbright Scholar grant to conduct research and teach next winter at Hadassah Hospital and Hebrew University in Jerusalem.
Smilow Cancer Hospital Hematology Program staff, friends, and families were recently recognized as a 1st place corporate team by the Leukemia & Lymphoma Society for their efforts raising over $2000 to support the Society in its annual Light the Night Walk at Lighthouse Point.
Congratulations to Yale Cancer Center members Peter Glazer, Alanna Schepartz, Craig Crews, and Vasilis Vasiliou, who were recently elected into the Connecticut Academy of Science and Engineering. Election to the Academy is on the basis of scientific and engineering distinction achieved through significant contributions in scientific and engineering excellence.
Many Yale Cancer Center faculty members participated in the 15th Annual Targeted Therapies of Lung Cancer Meeting in Santa Monica, CA last week, co-chaired by Roy Herbst, MD, PhD. Sponsored by the International Association for the Study of Lung Cancer, the invitation-only meeting gathers the top scientists to discuss the latest advances in the treatment of lung cancer with targeted therapies.
The Breast Center at Smilow Cancer Hospital at Yale-New Haven has received Three-Year Full Accreditation from the American College of Surgeons, National Accreditation Program for Breast Centers. NAPBC Accreditation is the seal of approval for breast centers from the American College of Surgeons and formally acknowledges their commitment to providing the highest quality evaluation and management of patients with breast disease. Learn More>>
Narendra Wajapeyee, PhD, Assistant Professor of Pathology and a member of the Yale Cancer Center Signal Transduction Program, has received a R21 grant from National Cancer Institute to study the role of metabolic alteration in melanoma biology and therapy. The $400,000 grant is in collaboration with investigators Gary Cline and Yuval Kluger. Dr. Wajapeyee also received a research grant award from Hirshberg Foundation for Pancreatic Cancer research to identify the drivers of pancreatic cancer.
Xiaoyong Yang, PhD, Associate Professor of Comparative Medicine and a member of the Yale Cancer Center Signal Transduction Program, has received an American Cancer Society Research Scholar Grant to study the Control of Cancer Metabolism by O-Linked Glycosylation. The four-year grant totals $792,000.
The National Cancer Institute has awarded Don Nguyen, PhD, Assistant Professor of Pathology and a member of the Signal Transduction Research Program, a 5-year R01 grant ($1,724,760 total), to study the role of metabolic stress in lung cancer metastasis. This project will be performed in collaboration with Gary Cline and Qin Yan. The title of the grant is "A novel lineage pathway controls metabolic adaptation by metastatic lung cancers."
Congratulations to Abhijit Patel, MD, PhD, Assistant Professor of Therapeutic Radiology and a member of the Radiobiology and Radiotherapy Program. Dr. Patel has received a $200K grant from the Brozman Foundation to study "Ultrasensitive detection of tumor DNA in blood for early diagnosis of ovarian cancer."The annual Lion Heart Grants for Breast Cancer Research were awarded to three Yale Cancer Center investigators for 2015:
Donald Engelman, PhD:Targeting Chemotherapy in Breast Cancer: Weakly-acidic prodrugs bias drug uptake toward tumors
Vikram Wali, PhD: Exploiting Metabolic Isoenzyme Shifts in Breast Cancer to Discover Novel Therapies
Vikram Wali, PhD and Chistos Hatzis, PhD: Evaluation of New Treatment Strategy for Triple Negative Breast Cancer Involving Combinations of Cancer Stem Cell Specific Drugs and Standard ChemotherapyAt the Annual American Society of Hematology Conference in December, the following students received abstract achievement awards: Linette Bosques, Amalyah Figueroa, Chad Sanada, Alexandra Teixeira, Siying Zou, Shiny Nair, and Roger Kim.
Suchitra Krishnan-Sarin, PhD, Associate Professor of Psychiatry and a member of the Yale Cancer Center Cancer Prevention and Control Program, has been appointed to the Board of Trustees of the Connecticut Tobacco and Health Trust Fund.
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine and Professor of Pharmacology and Chief of Medical Oncology at Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, was one of four US oncologists honored recently with the Bonnie J. Addario Lung Cancer Foundation's (ALCF) Excellence in Collaboration and Innovation Award. Earlier this year, the foundation gave Dr. Herbst its 2014 Addario Leadership Award for his expertise in lung cancer treatment and research.
Congratulations to Kathryn Pratt, RN, BSN who was honored as one of 5 finalists for the 2014 The Schwartz Center Compassionate Caregiver Award at the Schwartz Center annual dinner last week. Kathryn is a nurse coordinator for our Stem Cell Transplant Unit. "Kathryn gives patients confidence in their decisions to move forward with transplant and provides the connection and support they need during this very scary time," said her nominating colleague.
Last week, Yale University President Peter Salovey awarded the inaugural President's Award for Staff Excellence to our Pathology Tissue Services Team, one of Yale Cancer Center's8 Shared Resources. The lab is an extremely valuable resource for translational research because it provides tissue samples to investigators for laboratory testing. Congratulations to the entire team on this well deserved recognition of excellence!
The Blavatnik Family Foundation has awarded Pantelis Rompolas, PhD with a Regional Award of $10,000 in recognition of his contributions to our understanding of tissue development and regeneration. Dr. Rompolas is a postdoctoral fellow in Dr. Valentina Greco's laboratory.
Hari Deshpande, MD presented at the American Thyroid Association Annual Meeting on the Frequency of Lymph Node Involvement in Parathyroid Carcinoma: A Seer Database Analysis. The poster was done in collaboration with Drs. Udelsman, Carling, Quinn, Holt, Inzucchi, Burtness, Morgensztern, and Callender.
W. Mark Saltzman, PhD, has been elected to the Institute of Medicine (IOM). Dr. Saltzman is the Goizueta Foundation Professor and Chair of the Department of Biomedical Engineering and a pioneer in the fields of drug delivery, biomaterials, nanobiotechnology, and tissue engineering. He is a member of the Yale Cancer Center's Developmental Therapeutics Program.
Don X. Nguyen, PhD has received a one-year, $50,000 grant from the Lung Cancer Research Foundation (LCRF) to study the efficacy of drugs that target the proteasome in treating metastatic lung cancer.
Lynn T. Tanoue, MD, Professor of Medicine (Pulmonology), has been named President-Elect of the Yale-New Haven Hospital Medical Board, which sponsors numerous committees to evaluate and improve the professional activities of the medical staff and the quality of healthcare at Yale-New Haven Hospital.
Sarah Goldberg, MD, MPH has been awarded the 2014 SWOG/Hope Foundation Coltman Fellowship. The fellowship engages outstanding young investigators from SWOG affiliated institutions in learning clinical trial methodology within an academic and cooperative group environment that will lead to independent clinical research.
Benjamin Toll, PhD has been awarded an R21 grant from the NIH to implement a smoking cessation clinical trial evaluating the differences between standard care intervention (counseling plus nicotine replacement) and standard care plus monetary rewards for smoking cessation in presurgical cancer patients. The primary aim of the proposed study is to develop an effect size for smoking cessation at the time of surgery (7-day point prevalence), with a secondary aim of creating an effect size for long-term abstinence at 3 months post-surgery. He and his research team will also examine exploratory outcomes of perioperative complications and rates of continuous abstinence. Dr. Roy Herbst is a co-investigator on the trial with Dr. Toll.
Linda Niccolai, PhD was awarded an administrative supplement grant to the Cancer Center core grant for one year of support to fund her project on "Increasing Human Papillomavirus Vaccination Coverage among Adolescents in Connecticut."
James Yu, MD received a PhRMA Foundation Research Starter Grant at the Turning The Tide Against Cancer Conference last week. The grant will support his research on "Quantifying the Benefit of Modern Cancer Therapy for Elderly Patients: A Population Level Measurement."
Congratulations to Dr. Vincent DeVita, the Amy and Joseph Perella Professor of Medical Oncology and former Director of Yale Cancer Center, who received the prestigious honor of having developed the treatment for Hodgkins Disease, MOPP, which was voted as the Top Advance in 50 Years of Modern Oncology by the American Society of Clinical Oncology (ASCO).
Melinda Irwin, PhD has received a two-year grant from the American Institute for Cancer Research. The AICR award will expand Dr. Irwin's LEAN study and enroll 200 overweight breast cancer survivors and complete a 6-month post-intervention assessment of maintenance of weight, as well as changes in physical activity, diet, and quality of life.
Qin Yan, PhD, Associate Professor of Pathology, and a member of the Yale Cancer Center Cancer Genetics and Genomics Program, was awarded a Department of Defense Breast Cancer Research Program Breakthrough Award to support his research project, "Targeting an Epigenetic Regulator to Suppress Breast Cancer Metastasis." This 3-year project ($700,000 direct cost and $1,165,498 in total cost) will be conducted in collaboration with Drs. Don Nguyen, David Stern, and Carmen Booth.
Narendra Wajapeyee, PhD, Assistant Professor of Pathology, and a member of the Yale Cancer Center Signal Transduction Program, received a Biomedical Research Grant from the American Lung Association for his studies on "Personalized therapy of p53-mutant lung cancers."
Don Nguyen, PhD, a member of the Yale Cancer Center Signal Transduction Program, was awarded a 2-year R21 grant from the NCI, entitled: "Epigenetic modulation of lung cancer metastasis by a novel long intergenic RNA." The project will be done in collaboration with Dr. David Rimm.
Melinda Irwin, PhD, Co-director of the Cancer Prevention and Control Program, has received a grant from the CT Breast Health Initiative to support dissemination of Lifestyle, Exercise, and Nutrition (LEAN) Study intervention by testing her team's LEAN book as an intervention without the addition of counseling.
Stephanie Halene, MD, received a grant from the Evans Foundation to support her research on Molecular mechanisms underlying deregulated hematopoiesis caused by mutations in the serine-rich splicingfactor 2 (SRSF2) in myelodysplasia (MDS). Her collaborators on the grant include Giovanni Stefani, Toma Tebaldi, Scott Hiebert, Yorgo Modis, Yuval Kluger, and Manoj Pillai.
Lieping Chen, MD, PhD, the United Technologies Corporation Professor of Cancer Research at Yale Cancer Center and Professor of Immunobiology, Dermatology, and Medicine at Yale School of Medicine, has been named a 2014 William B. Coley Award winner. The Coley award is the top prize given by the Cancer Research Institute at its annual symposium. Dr. Chen will give the 22nd annual William B. Coley lecture during the symposium in New York City this October.
The Department of Public Health has released the 2014 Biomedical Trust Fund Award Grants. Three Yale Cancer Center members have received grant funds:
Stephanie Halene, PhD: The goal of this project is to identify mechanisms of relapse in patients with acute myeloid leukemia (AML) and to model AML relapse in humanized immunodeficient mice with the ultimate goal to develop and test novel treatments.
Collaborators: Richard Flavell, Anthony Rongvaux, Nikolai Podoltsev, Steven Gore, Natalia Neparidze, Terri Parker, Caroline Cromwell, Alfred Lee, Steven Kleinstein, and Shrikant Mane.
Edward Kaftan, PhD: The goals of this project are to determine the optimal dose and dosing schedule for the protective drugs and to determine the requirement of neuronal calcium sensor 1 (NCS1) in the development of chemotherapy-induced peripheral neuropathy (CIPN).
Collaborators: Barbara Ehrlich and Paul Eder.
Michael Robek, PhD: The purpose of this project is to develop a safe and effective therapeutic vaccine to cure chronic hepatitis B virus (HBV) infection and prevent the complications such as liver cancer that occur as a consequence of this disease.
Collaborator: Michael Rose
Roy Decker, MD, PhD, Associate Professor of Therapeutic Radiology and a member of Yale Cancer Center's Radiotherapy and Radiobiology Research Program, has been selected to represent SWOG on the Brain Malignancies Steering Committee (BMSC). The goal of the BMSC is to promote the best clinical and translational research for patients with brain cancer by critically reviewing phase II and phase III clinical trial concepts.
S. David Hudnall, MD, Professor of Pathology and Laboratory Medicine and a member of Yale Cancer Center's Molecular Virology Program, recently published a textbook through Springer entitled, "Viruses and Human Cancer." The book provides a comprehensive review of the seven currently known human tumor viruses and their associated cancers.
Sigma Theta Tau International (STTI), the Honor Society of Nursing, has announced its 2014 Nurse Researcher Hall of Fame inductees, which includes Ruth McCorkle, PhD, RN, FAAN, Assistant Director of Psychosocial Oncology Research at Yale Cancer Center, Florence Schorske Wald Professor
of Nursing, and Professor of Epidemiology. The induction ceremony will take place during STTI's 25th International Nursing Research Congress in Hong Kong, July 24-28, 2014.
Abhijit Patel, MD, PhD, Assistant Professor of Therapeutic Radiology and a member of our Radiobiology and Radiotherapy Program, has been awarded an Early Detection Research Award from the LUNGevity Foundation. The award is for $200K over 2 years and will support his research into "Detection of early-stage lung cancers via tumor DNA in blood."
Roy S. Herbst, MD, PhD, Chief of Medical Oncology, Ensign Professor of Medicine, and Associate Director of Translational Medicine, was awarded the Alvin S. Slotnik Lecture Award for notable contributions to cancer research from Dana-Farber/Brigham and Women's Cancer Center.
Susan Mayne, PhD, was selected for the inaugural Excellence in Education Award from the Society for Epidemiologic Research. The Excellence in Education award is presented to an individual who has made substantial contributions to the field of epidemiology through mentoring, training, and/or teaching.
Valentina Greco, PhD, Assistant Professor of Genetics and Dermatology and a member of our Molecular Virology Program, has been selected as the recipient of the American Society for Cell Biology Women in Cell Biology 2014 Junior Award for Excellence in Research Award. The award recognizes exceptional scientific contributions to cell biology, development of a strong independent research program, and exhibiting the potential for continued scientific achievement and leadership.
Alfred L.M. Bothwell, PhD, Professor of Immunobiology and a member of our Immunology and Immunotherapy Program, has received the Inaugural Wendy U. and Thomas C. Naratil Pioneer Award from Women's Health Research at Yale to support his project to study "Personalized Medicine" for the Most Lethal Endometrial Cancer. Dr. Bothwell will look for new, more effective treatments for uterine serous cancer, a particularly aggressive form of endometrial cancer that accounts for 10 percent of endometrial cancer cases, but is responsible for nearly 40 percent of endometrial cancer deaths.
Andrew T. Putnam, MD, Assistant Professor of Medicine (Medical Oncology) and a member of Smilow Cancer Hospital at Yale-New Haven's Palliative Care Medicine Program, was awarded his certification for completion of the 2013-2014 Medical Education Fellowship through the Yale School of Medicine's Teaching and Learning Center at the Yale Medical Education conference. Dr. Putnam also presented a poster at the conference entitled, "Faculty Development to Acquire Effective Communication Skills: Tailoring our Communication to Best Suit our Patients."
Simon Kim, MD, MPH, Assistant Professor of Urology, received a Career Development Award from the Conquer Cancer Foundation at this year's ASCO meeting. The three-year, $200,000 grant will support his research project on "National Trends in Active Surveillance for Prostate Cancer and Barriers to its Use."
Yale School of Medicine presented The Charles W. Bohmfalk Prize for teaching in the basic sciences to Susan Baserga, PhD, MD, Professor of Molecular Biophysics and Biochemistry, of Genetics, and of Therapeutic Radiology, and a member of our Genetics and Genomics Research Program.
Douglas E. Brash, Professor of Therapeutic Radiology and a member of our Radiobiology and Radiotherapy Program, will be awarded the 2014 Finsen Medal of the International Union of Photobiology. The IUP Congress presents the medal, recognizing lifetime achievement in photobiology, every five years. It commemorates Niels R. Finsen, recipient of the 1903 Nobel Prize in Physiology or Medicine for his studies on phototherapy of cutaneous tuberculosis. Dr. Brash's laboratory has elucidated many of the steps through which sunlight causes skin cancer.
Alanna Schepartz, PhD, Milton Harris Professor of Chemistry and Professor of Molecular, Cellular & Developmental Biology, and a member of Yale Cancer Center's Developmental Therapeutics Program, has been elected into the National Academy of Sciences.
David Schatz, PhD, Professor of Immunobiology and of Biophysics and Biochemistry and a member of Yale Cancer Center's Immunology and Immunotherapy Program, has been elected in to the American Academy of Arts and Sciences.
Roy Herbst, MD, PhD participated in the National Forum on the Future of Health Care at the National Press Club in Washington, DC last week and presented on Research in the Age of Personalized Medicine: Lung Cancer Master Protocol.
Daniel Petrylak, MD presented a poster during the 29th Annual EAU Congress in Stockholm, which was awarded a best poster award during the meeting. A phase 2 trial of prostate specific membrane antigen antibody drug conjugate (PSMA ADC) in taxane-treated metastatic castration-resistant prostate cancer (MCRPC).
Narendra Wajapeyee, MD has published Cancer Genomics and Proteomics: Methods and Protocols, as part of the Methods in Molecular Biology Book Series.
Cary Gross, MD has been awarded a 3-year grant from the American Cancer Society totaling $592,000 to study cancer disparities. His study will provide a timely assessment of personalized cancer care patterns and their impact on cancer equity, and identify potential leverage points to ensure optimum access to this novel and increasingly important aspect of cancer care.
Barbara Burtness, MD has recently published Molecular Determinants of Head and Neck Cancer in the Current Cancer Research Series (Series Editor: Wafik El-Deiry, MD).
Leah Ferrucci, PhD received the Best Poster Award at the American Society of Preventive Oncology meeting for her poster, "Ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma."
The American Academy of Orthopaedic Surgeons (AAOS) today presented the 2014 William W. Tipton Leadership Award to Gary E. Friedlaender, MD. The Tipton Leadership Award recognizes Academy members who have demonstrated outstanding leadership qualities that have benefitted the orthopaedic community, patients, and/or the American public.
Alfred Bothwell, PhD, a member of the Cancer Immunology Program, has received an RO1 grant entitled "Regulatory T cell Control of Intestinal Tumorigenesis" from the National Cancer Institutes. Dr. Bothwell's research will look to give important mechanistic insight into the specific inflammatory molecules that can compromise cells of the immune system.
The Connecticut Academy of Science and Engineering announced that six members of Yale Cancer Center were elected to membership on the basis of their distinguished contributions to science or engineering. The YCC members are Ronald Breaker, Lynn Cooley, Daniel DiMaio, James Duncan, Theodore Holford, Stephanie O'Malley, and Patrick Sung.
Kenneth Williams, PhD has received a $25,000 Yale School of Public Health Ovarian Cancer Pilot Research Grant, which is funded by the Tina Brozman Foundation, for one year to support his project, "Targeted Serum Proteome Assay for Early Detection of Ovarian Cancer.
Brian Shuch, MD has been named to the NCI/NIH PDQ Cancer Genetics Editorial Board and their Kidney Cancer Working Group.
Dr. Andrea Silber has received a $20,000 grant from the Breast Cancer Alliance to support community outreach and education in the New Haven community. Dr. Silber will use the funds to help provide breast cancer education and increase clinical trial participation at our Care Center at the St. Raphael Campus.
The National Academy of Inventors (NAI) has elected Mark Saltzman, PhD, Goizueta Foundation Professor of Biomedical Engineering, Chemical & Environmental Engineering, & Physiology, and a member of the Developmental Therapeutics Program, as a 2013 NAI Fellow.
Congratulations to Melissa Durand, MD, Veerle Bossuyt, MD, Christos Hatzis, PhD, and Lajos Pusztai, MD, DPhil - each of whom received a Lion Heart grant to support their breast cancer research work.
William K.C Cheung, PhD, a post doctoral associate in Don Nguyen's lab, was awarded a $100k grant from Uniting Against Lung Cancer to support his project titled: "Treating metastasis by differentiation therapy: Identifying druggable pathways."