Elisenda Bueichekú
she/her/hers
Associate Research ScientistCards
About
Research
Publications
2025
Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueicheku E, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3783.Peer-Reviewed Original ResearchTau accumulationCognitive changesPositron emission tomographyEarly cognitive changesLongitudinal positron emission tomographyAmyloid-betaCortical patternsAlzheimer's diseaseTauAging BrainCognitive scoresPreclinical ADOlder adultsSpatiotemporal levelsEmission tomographyBrainComplex roleAccumulationImaging markersAmyloid
2024
Cortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brainLower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals
Engels‐Domínguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, Prokopiou P, Bueichekú E, Kwong K, Rentz D, Salat D, Sperling R, Johnson K, Jacobs H. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals Of Neurology 2024, 96: 650-661. PMID: 39007398, PMCID: PMC11534559, DOI: 10.1002/ana.27022.Peer-Reviewed Original ResearchConceptsLocus coeruleus integrityClinical Dementia RatingBeta-amyloidHippocampal volumePositron emission tomographyClinical progressionAsymptomatic individualsReceiver operating characteristic analysisCortical tau depositionCox proportional hazards modelsLociAccumulation of pathologyBeta-amyloid burdenAsymptomatic older individualsMild cognitive impairmentTau depositionProportional hazards modelTau signalEC tauLocus coeruleusPET-negativeEntorhinal tauCognitive impairmentScreening instrumentCognitive declineTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive powerLocus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Pahl J, Prokopiou P, Bueichekú E, Schultz A, Papp K, Farrell M, Rentz D, Sperling R, Johnson K, Jacobs H. Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 119. PMID: 38822365, PMCID: PMC11140954, DOI: 10.1186/s13195-024-01485-w.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestLC integrityLocus coeruleusAttentional declineCognitive declineDigit-symbol substitution test performanceHarvard Aging Brain StudyResting-state functional MRILocus coeruleus integrityNetwork functional connectivityAlzheimer's diseaseAging Brain StudyPreclinical Alzheimer's diseaseCognitive follow-upYears of educationNeural reserveNeural correlatesAttentional performanceAttention deficitMixed effects analysisCortical target regionsSubstitution TestCognitive changesFrontoparietal connectivityFunctional MRISpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Commentaries, Editorials and LettersConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patternsMulti-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Communications Medicine 2024, 4: 65. PMID: 38580832, PMCID: PMC10997795, DOI: 10.1038/s43856-024-00497-9.Peer-Reviewed Original ResearchMemory declineMedial anterior prefrontal cortexAging BrainWhole-brain voxel-wiseAnterior prefrontal cortexRegion-of-interest analysisResting-state functional MRIObjective memory declineOccipito-parietal regionsMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksPrefrontal cortexMnemonic anosognosiaTau burdenBiomarkers of AD pathologyMode networkParieto-occipital areasFunctional network connectivity disruptionFunctional MRIBrain phenotypesVoxel-wiseBehavioral conditionsBehavioral biomarkers
2023
Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increasesCreativity at rest: Exploring functional network connectivity of creative experts
Orwig W, Setton R, Diez I, Bueichekú E, Meyer M, Tamir D, Sepulcre J, Schacter D. Creativity at rest: Exploring functional network connectivity of creative experts. Network Neuroscience 2023, 7: 1022-1033. PMID: 37781148, PMCID: PMC10473280, DOI: 10.1162/netn_a_00317.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingFunctional connectivityReduced connectivityAssociated with creative abilityReplicate prior findingsVisual cortexBrain network organizationStudies of functional connectivityFunctional brain connectivityLateral visual cortexFunctional network connectivityNeuroscience of creativityComplex brain processesNeuroimaging studiesGeneration of novel ideasBrain processesBrain connectivityConnectivity profilesCreative performanceCreative behaviorCortexPrimary visual cortexMagnetic resonance imagingNetwork organizationNegative associationTwo different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary
Palomar-García M, Villar-Rodríguez E, Pérez-Lozano C, Sanjuán A, Bueichekú E, Miró-Padilla A, Costumero V, Adrián-Ventura J, Parcet M, Ávila C. Two different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary. Brain And Language 2023, 237: 105231. PMID: 36716643, DOI: 10.1016/j.bandl.2023.105231.Peer-Reviewed Original ResearchConceptsLanguage control networkPicture naming taskOld wordsNaming TaskMeasured BOLD signal changesControl networkBOLD signal changesNative wordsPicture namingBrain networksSpanish wordsParietal regionsCortical networksCortical/subcortical networksHealthy participantsActivity patternsFunctional circuitsWordsSignal changesVocabularyTaskCognitive purposesFMRILanguageHippocampus