2024
An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen Age-Related Eye Disease Study Report Number 42
Agrón E, Domalpally A, Chen Q, Lu Z, Chew E, Keenan T, Groups A. An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen Age-Related Eye Disease Study Report Number 42. Ophthalmology 2024, 131: 1164-1174. PMID: 38657840, PMCID: PMC11416341, DOI: 10.1016/j.ophtha.2024.04.011.Peer-Reviewed Original ResearchAge-Related Eye Disease StudyProgression to late AMDReticular pseudodrusenLate AMDFive-year ratesProgression rateAge-related macular degenerationSeverity ScaleEye Disease StudyClinical trial cohortIncrease prognostic accuracyPost hoc analysisMacular degenerationAREDS2Prognostic accuracyTrial cohortRisk featuresHoc analysisRisk categorizationPseudodrusenAge-relatedBaselineDisease StudyRiskExternal validation
2022
DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity
Keenan T, Chen Q, Agrón E, Tham Y, Goh J, Lei X, Ng Y, Liu Y, Xu X, Cheng C, Bikbov M, Jonas J, Bhandari S, Broadhead G, Colyer M, Corsini J, Cousineau-Krieger C, Gensheimer W, Grasic D, Lamba T, Magone M, Maiberger M, Oshinsky A, Purt B, Shin S, Thavikulwat A, Lu Z, Chew E, Group A, Ajilore P, Akman A, Azar N, Azar W, Chan B, Cox V, Dave A, Dhanjal R, Donovan M, Farrell M, Finkel F, Goblirsch T, Ha W, Hill C, Kumar A, Kent K, Lee A, Patel P, Peprah D, Piliponis E, Selzer E, Swaby B, Tenney S, Zeleny A. DeepLensNet: Deep Learning Automated Diagnosis and Quantitative Classification of Cataract Type and Severity. Ophthalmology 2022, 129: 571-584. PMID: 34990643, PMCID: PMC9038670, DOI: 10.1016/j.ophtha.2021.12.017.Peer-Reviewed Original ResearchConceptsAge-related cataractSingapore Malay Eye StudyAnterior segment photographsCortical lens opacitiesPosterior subcapsular cataractCommon typeSlit-lamp photographsLeast common typeMedical studentsEye StudyNuclear sclerosisSubcapsular cataractLens opacitiesCataract typesRetroillumination photographsCataract assessmentOphthalmologistsCataract severityCataractExternal validationDiagnosisSeveritySclerosisStudy dataset
2021
Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration
Chen Q, Keenan T, Allot A, Peng Y, Agrón E, Domalpally A, Klaver C, Luttikhuizen D, Colyer M, Cukras C, Wiley H, Magone M, Cousineau-Krieger C, Wong W, Zhu Y, Chew E, Lu Z, Group F. Multimodal, multitask, multiattention (M3) deep learning detection of reticular pseudodrusen: Toward automated and accessible classification of age-related macular degeneration. Journal Of The American Medical Informatics Association 2021, 28: 1135-1148. PMID: 33792724, PMCID: PMC8200273, DOI: 10.1093/jamia/ocaa302.Peer-Reviewed Original ResearchConceptsColor fundus photographyAge-related macular degenerationFundus autofluorescenceReticular pseudodrusenMacular degenerationStandard color fundus photographyReceiver-operating characteristic curveAdvanced imaging modalitiesExternal validationRetinal specialistsAMD featuresFundus photographyGeographic atrophyPigmentary abnormalitiesAMD diagnosisImaging modalitiesCharacteristic curvePseudodrusenDegeneration
2020
Predicting risk of late age-related macular degeneration using deep learning
Peng Y, Keenan T, Chen Q, Agrón E, Allot A, Wong W, Chew E, Lu Z. Predicting risk of late age-related macular degeneration using deep learning. Npj Digital Medicine 2020, 3: 111. PMID: 32904246, PMCID: PMC7453007, DOI: 10.1038/s41746-020-00317-z.Peer-Reviewed Original ResearchLate age-related macular degenerationAge-related macular degenerationHigher prognostic accuracyClinical standardsMacular degenerationPrognostic accuracyIndependent cohortLargest longitudinal clinical trialsProbability of progressionSight-threatening stagesColor fundus photographsLongitudinal clinical trialsAMD patientsRetinal specialistsClinical trialsFundus photographsSpecialty clinicHigh riskClinical actionsSurvival analysisMedical interventionsIndividual riskAREDS2AREDSExternal validation