Yilin Yang
Associate Research ScientistAbout
Research
Publications
2026
Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages
Ma R, Gong L, Dong C, Utsumi T, Qi J, Zhuang Z, Zhang X, Yang Y, McConnell M, Huang H, Iwakiri Y. Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages. Cellular And Molecular Gastroenterology And Hepatology 2026, 20: 101728. PMID: 41565157, PMCID: PMC13090736, DOI: 10.1016/j.jcmgh.2026.101728.Peer-Reviewed Original Research
2024
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original Research
2023
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell M, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. AJP Gastrointestinal And Liver Physiology 2023, 325: g379-g390. PMID: 37605828, PMCID: PMC10887843, DOI: 10.1152/ajpgi.00139.2023.Peer-Reviewed Original Research
2021
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. Journal Of Hepatology 2021, 75: 377-386. PMID: 33675874, PMCID: PMC8292196, DOI: 10.1016/j.jhep.2021.02.028.Peer-Reviewed Original Research
2020
Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis
Su T, Yang Y, Lai S, Jeong J, Jung Y, McConnell M, Utsumi T, Iwakiri Y. Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis. Cellular And Molecular Gastroenterology And Hepatology 2020, 11: 1139-1161. PMID: 33340713, PMCID: PMC7903131, DOI: 10.1016/j.jcmgh.2020.12.007.Peer-Reviewed Original Research
2019
Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis
An L, Peng L, Sun N, Yang Y, Zhang X, Li B, Liu B, Li P, Chen J. Tanshinone IIA Activates Nuclear Factor-Erythroid 2-Related Factor 2 to Restrain Pulmonary Fibrosis via Regulation of Redox Homeostasis and Glutaminolysis. Antioxidants & Redox Signaling 2019, 30: 1831-1848. PMID: 30105924, DOI: 10.1089/ars.2018.7569.Peer-Reviewed Original Research
2018
Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling
Lu Y, Li L, Yang Y, Yin X, Liu Q, Zhang L, Liu K, Liu B, Li J, Qi L. Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. Cell Death & Disease 2018, 9: 672. PMID: 29867110, PMCID: PMC5986788, DOI: 10.1038/s41419-018-0708-5.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAnimals, NewbornApoptosisDynaminsEnzyme ActivationExtracellular Signal-Regulated MAP KinasesGlucoseIsoproterenolMaleMice, Inbred ICRMitochondriaMitochondrial DynamicsMitochondrial ProteinsModels, BiologicalMyocardial IschemiaMyocytes, CardiacOxygenProtein Kinase C-deltaRatsReceptors, G-Protein-CoupledSignal TransductionSuccinic Acid
2017
Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction
Liu Q, Zhang F, Zhang W, Pan A, Yang Y, Liu J, Li P, Liu B, Qi L. Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction. Theranostics 2017, 7: 4001-4012. PMID: 29109794, PMCID: PMC5667421, DOI: 10.7150/thno.18788.Peer-Reviewed Original ResearchSuccinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1
Li J, Yang Y, Li L, Zhang L, Liu Q, Liu K, Li P, Liu B, Qi L. Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1863: 2835-2847. PMID: 28736181, DOI: 10.1016/j.bbadis.2017.07.017.Peer-Reviewed Original ResearchGinsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1
Yang Y, Li J, Liu K, Zhang L, Liu Q, Liu B, Qi L. Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1. Cell Death & Disease 2017, 8: e2625-e2625. PMID: 28230856, PMCID: PMC5386487, DOI: 10.1038/cddis.2017.43.Peer-Reviewed Original Research
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