Kriti Agrawal
About
Research
Publications
2026
T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B
Johnson J, Agrawal K, Al-Lamki R, Zhang F, Wang X, Tobiasova Z, Taleb S, Liburd S, Rodriguez L, Martins A, Flavell R, Robert M, Sefik E, Pober J. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2525433123. PMID: 41642982, PMCID: PMC12890992, DOI: 10.1073/pnas.2525433123.Peer-Reviewed Original ResearchConceptscytotoxic T lymphocytesT cell receptorHLA-ET lymphocytesproximity ligation assayclass II HLA moleculesT cell receptor for antigenHLA-B mRNAcytolytic T lymphocytesT cell subsetsceliac diseasereceptor for antigenactive celiac diseaseligation assayCTL activityHLA-E.T cellsantigen presentationfrequent bindingHLA moleculesduodenal biopsiesHLA-Bsingle-cell RNA sequencingnormal controlsHLA-B.
2025
Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody
Newton N, Agrawal K, Odell A, Tracy T, Hacket C, Eldrup A, Whitfield M, Martyanov V, Girardi M, Sefik E, Flavell R, Odell I. Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody. Blood 2025, 146: 3201-3212. PMID: 40961242, PMCID: PMC12643462, DOI: 10.1182/blood.2025029836.Peer-Reviewed Original Researchscleroderma/systemic sclerosistherapeutic antibodieschronic graft-versus-host diseasesclerotic skingraft-versus-host diseasepatients' qualityfibrotic diseaseslungs of patientsendogenous TLR4 ligandspatients' quality of lifeKnock-In Micefibrotic skin diseasesantifibrotic mechanismssingle-cell transcriptome profilingskin fibrosislocalized sclerodermaneutralizing antibodiesEGFR ligandsEREG expressionTLR4 ligandTIMP1 expressionTLR4 signalingpatient mortalitypatientstype I collagenHumanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo H, Rongvaux A, Kluger Y, Flavell R. Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426546122. PMID: 40956886, PMCID: PMC12478129, DOI: 10.1073/pnas.2426546122.Peer-Reviewed Original ResearchConceptsbone marrowhuman CD47human granulocyte-macrophage progenitorshuman immune developmentmature human monocyteshuman neutrophilshumanized mouse modelneutrophil extracellular trap formationhuman hematopoietic stemgranulocyte-macrophage progenitorshuman M-CSFhuman immune responsegenetically modified miceresponse to inflammationextracellular trap formationhuman bone marrowCD47 promoterhuman immune systemphysiological levelsNK cellshumanized micedendritic cellshematopoietic stemmyeloid lineagehuman hematopoiesisEngineering Mice to Study Human Immunity
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025, 43: 451-487. PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementshumanized micehuman hematopoiesisimmune responseimmune systemhumanized mouse modelhuman hematopoietic stemimmunocompromised murine hostsresident immune cellshuman immune responsestudy human immunityhuman immune systemintegration of multi-omicshematopoietic stemimmune cell growthimmune cellsEngineered Miceprogenitor cellsmouse modelimmunological diseasesmurine hostcancer treatmentpreclinical drugshuman immunitymicemodel disease
2024
The single-cell opioid responses in the context of HIV (SCORCH) consortium
Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, Byrareddy S, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton K, Giglio M, Giorgi F, Gok B, Guda C, Hadas E, Herb B, Hu W, Huttner A, Ishmam M, Jacobs M, Kelschenbach J, Kim D, Lee C, Liu S, Liu X, Madras B, Mahurkar A, Mash D, Mukamel E, Niu M, O’Connor R, Pagan C, Pang A, Pillai P, Repunte-Canonigo V, Ruzicka W, Stanley J, Tickle T, Tsai S, Wang A, Wills L, Wilson A, Wright S, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng C, Corley M, Fox H, Gerstein M, Gummuluru S, Heiman M, Ho Y, Kellis M, Kenny P, Kluger Y, Milner T, Moore D, Morgello S, Ndhlovu L, Rana T, Sanna P, Satterlee J, Sestan N, Spector S, Spudich S, Tilgner H, Volsky D, White O, Williams D, Zeng H. The single-cell opioid responses in the context of HIV (SCORCH) consortium. Molecular Psychiatry 2024, 29: 3950-3961. PMID: 38879719, PMCID: PMC11609103, DOI: 10.1038/s41380-024-02620-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementscontext of human immunodeficiency virushuman immunodeficiency virussubstance use disordersopioid responseanimal modelseffects of substance use disordersopioid pain medicationsprevalence of co-morbid conditionschronic pain syndromesstage of diseasecell typesaffected cell typesco-morbid conditionspain syndromeimmunodeficiency viruspain medicationopioid addictionincreased riskrisk factorshuman cohortsdrug addictionbrain tissue collectionbrain cell typestissue collectionsingle-cell level
2023
Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation
Lyu F, Burzynski C, Fang Y, Tal A, Chen A, Kisa J, Agrawal K, Kluger Y, Taylor H, Tal R. Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation. JCI Insight 2023, 8: e172216. PMID: 37815869, PMCID: PMC10721256, DOI: 10.1172/jci.insight.172216.Peer-Reviewed Original ResearchConceptsCXCR4-deficient miceplacental vascular developmentNK cellsCxcr4 deletionnormal placental vascular developmentplacental developmentNK cell dysfunctionNK cell expressionNK cell infiltrationNK cell functionrole of CXCR4cell functionmaternal-fetal interfaceimmune cell functionearly placental developmentWt CXCR4immune dysregulationvascular developmentgiant cell layerimmune toleranceCXCR4 expressionperipheral bloodpregnancy failurecell infiltrationpregnancy lossIL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsbone marrow-derived immune cellsIL-6human hematopoietic stem cellsimmune cellsT cellsscleroderma skinsoluble IL-6 receptorCD8 T cellshumanized mouse modelpathogenesis of sclerodermamesenchymal cellsfibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationhuman IL-6human T cellsexpression of collagenfibrosis improvementpansclerotic morpheahuman endothelial cellshumanized micereduced markersskin graftshuman CD4
2021
Cellular diversity of human cerebral organoids revealed by single cell RNA-seq
Dang J, Tiwari S, Agrawal K, Hui H, Qin Y, Rana T. Cellular diversity of human cerebral organoids revealed by single cell RNA-seq. Molecular Psychiatry 2021, 26: 1043-1043. DOI: 10.1038/s41380-021-01064-7.Peer-Reviewed Original ResearchRapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity
Tang M, Tiwari S, Agrawal K, Tan M, Dang J, Tam T, Tian J, Wan X, Schimelman J, You S, Xia Q, Rana T, Chen S. Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity. Small 2021, 17: e2006050-e2006050. PMID: 33502104, PMCID: PMC8049977, DOI: 10.1002/smll.202006050.Peer-Reviewed Original Research
2020
m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana T. m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy. The EMBO Journal 2020, 39: embj2020104514. PMID: 32964498, PMCID: PMC7560214, DOI: 10.15252/embj.2020104514.Peer-Reviewed Original ResearchAdenosineAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell ProliferationChemokine CXCL10Chemokine CXCL9Colorectal NeoplasmsCytokinesHumansImmune Checkpoint InhibitorsImmunohistochemistryImmunotherapyInterferon Regulatory Factor-1Interferon-gammaMelanomaMethyltransferasesMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorRNA-Binding ProteinsRNA-SeqSTAT1 Transcription FactorTumor Microenvironment