Kevin Tse
About
Research
Publications
2026
Fertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage
Rainsford S, Tse K, Walters B, Oh J, Sumigray K, Lesch B, Smith Z. Fertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage. Biology Of Reproduction 2026, 114: 1210-1226. PMID: 41556312, PMCID: PMC13079458, DOI: 10.1093/biolre/ioag010.Peer-Reviewed Original Researchwild type spermintracytoplasmic sperm injectionprotamine 2early stages of embryogenesisstages of embryogenesisepididymal maturationKO spermepididymal spermpaternal genomeinduction of DNA damageprotamine-2sperm motilityfunctional zygotepaternal genetic materialmaternal meiosisPRM2spermsperm DNAoocyte's abilityblastocyst stagesperm injectionpreimplantation developmentspermatozoan DNAgenetic materialpronucleus development
2024
LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs
Zhang J, Ataei L, Mittal K, Wu L, Caldwell L, Huynh L, Sarajideen S, Tse K, Simon M, Mazid M, Cook D, Trcka D, Kwan T, Hoffman M, Wrana J, Esteban M, Ramalho-Santos M. LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs. Developmental Cell 2024, 60: 186-203.e13. PMID: 39413784, DOI: 10.1016/j.devcel.2024.09.024.Peer-Reviewed Original ResearchAutonomous transposons tune their sequences to ensure somatic suppression
Ilık İ, Glažar P, Tse K, Brändl B, Meierhofer D, Müller F, Smith Z, Aktaş T. Autonomous transposons tune their sequences to ensure somatic suppression. Nature 2024, 626: 1116-1124. PMID: 38355802, PMCID: PMC10901741, DOI: 10.1038/s41586-024-07081-0.Peer-Reviewed Original ResearchConceptstransposable elementsSAFB proteinsPiwi-interacting RNA pathwayRNA-basedintronic transposed elementsRNA processing signalspre-mRNA processingintronic spacenested genespostmeiotic spermatidsautonomous transposonsDNA transposonsRNA pathwayscassette exonssplicing codesplicing eventsgenome integrityTE exonizationhuman genesL1 elementsRNA synthesishost genestissue-specificSAFBsomatic cells
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Yale Stem Cell Center
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Amistad Street Building
10 Amistad Street
New Haven, CT 06519