Juan Huang
Associate Research Scientist (Endocrinology)Cards
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Research
Publications
2026
IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation
Pearson J, Li Y, Huang J, Peng J, Wong F, Wen L. IL17-deficient NOD mice are protected from autoimmune diabetes due to decreased antigen presentation and T cell activation. Frontiers In Immunology 2026, 16: 1728313. PMID: 41613137, PMCID: PMC12850519, DOI: 10.3389/fimmu.2025.1728313.Peer-Reviewed Original Research
2025
Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice
Zhang L, Xing Y, Wang P, Gu J, Peng J, Huang J, Pearson J, Hu Y, Zhao H, Wong F, Wen L. Pdgfrα deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice. Frontiers In Endocrinology 2025, 16: 1630979. PMID: 41234234, PMCID: PMC12605365, DOI: 10.3389/fendo.2025.1630979.Peer-Reviewed Original ResearchMonocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
Li J, Liang X, Zhao M, Luo W, Huang J, Xiao Y, Huang J, Zhao B, Zhou Z. Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes. EBioMedicine 2025, 120: 105946. PMID: 40957221, PMCID: PMC12466144, DOI: 10.1016/j.ebiom.2025.105946.Peer-Reviewed Original Research
2024
Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D
Yang X, Huang J, Peng J, Wang P, Wong F, Wang R, Wang D, Wen L. Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D. Frontiers In Immunology 2024, 15: 1413177. PMID: 38903498, PMCID: PMC11187306, DOI: 10.3389/fimmu.2024.1413177.Peer-Reviewed Original ResearchTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchEffects of gut microbiome on type 1 diabetes susceptibility and complications: A large‐scale bidirectional Mendelian randomization and external validation study
Guo K, Ye J, Li J, Huang J, Zhou Z. Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large‐scale bidirectional Mendelian randomization and external validation study. Diabetes Obesity And Metabolism 2024, 26: 3306-3317. PMID: 38751358, DOI: 10.1111/dom.15658.Peer-Reviewed Original ResearchGut microbiota and therapy for obesity and type 2 diabetes
Zhang L, Wang P, Huang J, Xing Y, Wong F, Suo J, Wen L. Gut microbiota and therapy for obesity and type 2 diabetes. Frontiers In Endocrinology 2024, 15: 1333778. PMID: 38596222, PMCID: PMC11002083, DOI: 10.3389/fendo.2024.1333778.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Adverse effects of gestational diabetes mellitus on fetal monocytes revealed by single-cell RNA sequencing
Yin M, Zhang Y, Li X, Liu S, Huang J, Yu H, Li X. Adverse effects of gestational diabetes mellitus on fetal monocytes revealed by single-cell RNA sequencing. IScience 2023, 27: 108637. PMID: 38188508, PMCID: PMC10770529, DOI: 10.1016/j.isci.2023.108637.Peer-Reviewed Original ResearchElevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes
Li Z, Zhao M, Li J, Luo W, Huang J, Huang G, Xie Z, Xiao Y, Huang J, Li X, Zhao B, Zhou Z. Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes. Clinical Immunology 2023, 255: 109729. PMID: 37562723, DOI: 10.1016/j.clim.2023.109729.Peer-Reviewed Original ResearchDistinct signatures of gut microbiota and metabolites in different types of diabetes: a population-based cross-sectional study
Hu J, Ding J, Li X, Li J, Zheng T, Xie L, Li C, Tang Y, Guo K, Huang J, Liu S, Yan J, Peng W, Hou C, Wen L, Xu A, Zhou Z, Xiao Y. Distinct signatures of gut microbiota and metabolites in different types of diabetes: a population-based cross-sectional study. EClinicalMedicine 2023, 62: 102132. PMID: 37593224, PMCID: PMC10430172, DOI: 10.1016/j.eclinm.2023.102132.Peer-Reviewed Original Research
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