Jeong Hun Jo, PhD
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Hughes Lab
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Associate Research Scientist
Biography
Jeong Hun Jo, PhD grew up in Busan, South Korea and received a bachelor’s degree in electronic engineering as summa cum laude from Gyeongsang National University in Jinju, South Korea. He earned a Doctor of Philosophy in 2019 at the School of Interdisciplinary Bioscience and Bioengineering in Pohang University of Science and Technology (POSTECH) in Pohang, South Korea. His doctoral thesis was to investigate an age-dependent increase in glutamate decarboxylase 67 (GAD67) in mouse pancreatic islets. He joined Hughes Lab in 2019 as a Postdoctoral Research Associate right after graduation. After finishing 5-year postdoc, he became a Staff scientist in 2024 and then since July 1st, 2025, he joined new Hughes Lab at Yale as an Associate Research Scientist.
Departments & Organizations
Education & Training
- Staff Scientist
- Washington University School of Medicine (2025)
- Postdoctoral Research Associate
- Washington University School of Medicine (2024)
- PhD
- POSTECH, School of Interdisciplinary Bioscience and Bioengineering (2019)
- BS
- Gyeongsang National University, Electronic Engineering (2012)
Research
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Overview
Primary cilia are antenna-like structures acting as signaling-transducers in cells. Recently, Hughes Lab reported that beta cell primary cilia regulate glucose homeostasis via paracrine signaling and their motility controls insulin secretion in pancreatic islets. His main research interests are how 1) primary cilia mediate key signaling pathways (ex, Wnt, Hedgehog (Hh), Notch, and GPCR signaling etc.) and 2) primary cilia-relayed molecular mechanisms change between heathy and Type 2 Diabetic human pancreatic islets.
Medical Research Interests
ORCID
0000-0002-1056-0496Hughes Lab
Advancing research on cilia's role in pancreatic islet cell communication and function.
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Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Jing Hughes, MD, PhD
Shannon Townsend
Cilia
Islets of Langerhans
Diabetes Mellitus
Pancreas
Publications
Featured Publications
Islet primary cilia motility controls insulin secretion
Cho J, Li Z, Zhu L, Muegge B, Roseman H, Lee E, Utterback T, Woodhams L, Bayly P, Hughes J. Islet primary cilia motility controls insulin secretion. Science Advances 2022, 8: eabq8486. PMID: 36149960, PMCID: PMC9506710, DOI: 10.1126/sciadv.abq8486.Peer-Reviewed Original ResearchCitationsAltmetricPrimary cilia control glucose homeostasis via islet paracrine interactions
Hughes J, Cho J, Conway H, DiGruccio M, Ng X, Roseman H, Abreu D, Urano F, Piston D. Primary cilia control glucose homeostasis via islet paracrine interactions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 8912-8923. PMID: 32253320, PMCID: PMC7184063, DOI: 10.1073/pnas.2001936117.Peer-Reviewed Original ResearchCitationsAltmetricAxonemal Dynein Visualized in Primary Cilia via Expansion Microscopy
Dong X, Jo J, Hughes J. Axonemal Dynein Visualized in Primary Cilia via Expansion Microscopy. Cytoskeleton 2025, 83: 224-236. PMID: 40552592, PMCID: PMC12354234, DOI: 10.1002/cm.70004.Peer-Reviewed Original ResearchCitationsPrimary cilia regulate GLP-1 signaling in pancreatic β cells
Melena I, Jo J, Townsend S, DiGruccio S, Dong X, Zhu L, Campbell J, Hughes J. Primary cilia regulate GLP-1 signaling in pancreatic β cells. Molecular Metabolism 2026, 107: 102357. PMID: 41895439, PMCID: PMC13089038, DOI: 10.1016/j.molmet.2026.102357.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Intravital imaging reveals glucose-dependent cilia movement in pancreatic islets in vivo
Melnyk O, Guo J, Li Z, Jo J, Hughes J, Linnemann A. Intravital imaging reveals glucose-dependent cilia movement in pancreatic islets in vivo. Metabolism 2024, 163: 156105. PMID: 39667431, PMCID: PMC11718731, DOI: 10.1016/j.metabol.2024.156105.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Fluorescence imaging of beta cell primary cilia
Li Z, Cho J, Woodhams L, Hughes J. Fluorescence imaging of beta cell primary cilia. Frontiers In Endocrinology 2022, 13: 1004136. PMID: 36213262, PMCID: PMC9540379, DOI: 10.3389/fendo.2022.1004136.Peer-Reviewed Original ResearchCitationsAltmetricCilia Action in Islets: Lessons From Mouse Models
Cho J, Hughes J. Cilia Action in Islets: Lessons From Mouse Models. Frontiers In Endocrinology 2022, 13: 922983. PMID: 35813631, PMCID: PMC9260721, DOI: 10.3389/fendo.2022.922983.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2019
Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets.
Cho JH, Lee KM, Lee YI, Nam HG, Jeon WB. Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets. Islets 2019, 11: 33-43. PMID: 31084527, DOI: 10.1080/19382014.2019.1599708.Peer-Reviewed Original Research
2018
Effect of young exosomes injected in aged mice.
Lee BR, Kim JH, Choi ES, Cho JH, Kim E. Effect of young exosomes injected in aged mice. Int J Nanomedicine 2018, 13: 5335-5345. PMID: 30254438, DOI: 10.2147/IJN.S170680.Peer-Reviewed Original Research
2017
Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles.
Lee BR, Kim HR, Choi ES, Cho JH, Kim NJ, Kim JH, Lee KM, Razzaq A, Choi H, Hwang Y, Grimes CA, Lee BH, Kim E, In SI. Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles. Sci Rep 2017, 7: 12900. PMID: 29018212, DOI: 10.1038/s41598-017-11213-0.Peer-Reviewed Original Research
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