Christopher Regan, MD, FACC, FSCAI, RPVI
Associate Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2025
Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025, 81: 1518-1528.e13. PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
Regan C, Scierka L, Dardik A, Tonnessen B, Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 33: 466-471. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original Research
2023
Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original Research
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchSafety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions
Sheikh AB, Llanos-Chea F, Jelani QU, Anantha-Narayanan M, Attaran R, Schneider M, Ionescu C, Regan C, Nagpal S, Smolderen KG, Mena-Hurtado C. Safety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions. Journal Of Vascular Surgery 2021, 74: 746-755. PMID: 33592298, DOI: 10.1016/j.jvs.2021.01.045.Peer-Reviewed Original Research
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSafety and efficacy of paclitaxel drug-coated balloon in femoropopliteal in-stent restenosis
Anantha-Narayanan M, Love K, Nagpal S, Sheikh AB, Regan CJ, Mena-Hurtado C. Safety and efficacy of paclitaxel drug-coated balloon in femoropopliteal in-stent restenosis. Expert Review Of Medical Devices 2020, 17: 533-539. PMID: 32525406, DOI: 10.1080/17434440.2020.1770593.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUtility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis
Sheikh AB, Anantha-Narayanan M, Smolderen KG, Jelani QU, Nagpal S, Schneider M, Llanos F, Ionescu C, Regan C, Attaran R, Altin SE, Mena-Hurtado C. Utility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis. Vascular And Endovascular Surgery 2020, 54: 413-422. PMID: 32338163, DOI: 10.1177/1538574420920998.Peer-Reviewed Original Research
2019
Drug‐coated balloon versus plain old balloon angioplasty in femoropopliteal disease: An updated meta‐analysis of randomized controlled trials
Anantha‐Narayanan M, Shah SM, Jelani Q, Garcia S, Ionescu C, Regan C, Mena‐Hurtado C. Drug‐coated balloon versus plain old balloon angioplasty in femoropopliteal disease: An updated meta‐analysis of randomized controlled trials. Catheterization And Cardiovascular Interventions 2019, 94: 139-148. PMID: 30838719, DOI: 10.1002/ccd.28176.Peer-Reviewed Original ResearchAgedAmputation, SurgicalAngioplasty, BalloonCardiovascular AgentsCoated Materials, BiocompatibleEquipment DesignFemaleFemoral ArteryHumansLimb SalvageMalePeripheral Arterial DiseasePopliteal ArteryRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeVascular Access DevicesVascular PatencyReview of the Current Basic Science Strategies to Treat Critical Limb Ischemia
Haghighat L, Ionescu CN, Regan CJ, Altin SE, Attaran RR, Mena-Hurtado CI. Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia. Vascular And Endovascular Surgery 2019, 53: 316-324. PMID: 30808262, DOI: 10.1177/1538574419831489.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Academic Achievements & Community Involvement
Clinical Care
Overview
Christopher Regan, MD, is an interventional cardiologist, a specialist who uses minimally invasive catheter-based procedures to treat coronary artery disease and peripheral vascular disease—the narrowing or blocking of the arteries usually caused by cholesterol and fatty deposits.
Dr. Regan says he chose his field when he was in training and seeing patients with severe chest pain. “There was an interventional cardiologist who would do his work, and within an hour the patient would be thanking him and shaking his hand,” he says.
Almost 20 years later, some cases still require open heart surgery, but catheterization is providing an easier alternative in more situations. “No incision is needed for these procedures. We go through the skin and just use needles and tubes to fix the problem,” Dr. Regan says. He inserts a flexible tube, or catheter, through the skin and into the artery to guide in a small balloon to push the artery open. Then, he places a tube called a stent to keep it open.
Catheterization itself is changing, says Dr. Regan, who is also a researcher investigating ways to improve the devices he uses. While the procedure traditionally involves inserting a catheter in through the femoral artery in the groin area, smaller, specially designed tubes are making it possible to start more procedures in the radial artery from the wrist area. “That’s a fantastic advance because the patient doesn’t have to lay flat for a four- to six-hour period to allow the artery in the leg to heal,” he says. “The risk of bleeding and damage to the artery is reduced because the artery is so small that you would see even a small amount of blood right away, and you can just put some pressure on it.”
He especially enjoys his work when he walks a patient through a procedure and watches as the patient starts to understand it. “It brings a lot of comfort to them, and I can see that,” he says. “They may still be nervous, but I can see the change in them in the office visit. Also, these are procedures that only require moderate sedation, so patients are awake enough that I can tell them what's going on during the procedure. Then, I go over everything with them afterwards. And that's very gratifying.”
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Bundle Branch Block
Learn More on Yale MedicineAtrial Fibrillation
Learn More on Yale MedicineHypercholesterolemia (High Cholesterol)
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