Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsBoris Kholodenko
Research
Publications
Featured Publications
Control of cell state transitions
Rukhlenko O, Halasz M, Rauch N, Zhernovkov V, Prince T, Wynne K, Maher S, Kashdan E, MacLeod K, Carragher N, Kolch W, Kholodenko B. Control of cell state transitions. Nature 2022, 609: 975-985. PMID: 36104561, PMCID: PMC9644236, DOI: 10.1038/s41586-022-05194-y.Peer-Reviewed Original ResearchA systematic analysis of signaling reactivation and drug resistance
Kholodenko B, Rauch N, Kolch W, Rukhlenko O. A systematic analysis of signaling reactivation and drug resistance. Cell Reports 2021, 35: 109157. PMID: 34038718, PMCID: PMC8202068, DOI: 10.1016/j.celrep.2021.109157.Peer-Reviewed Original ResearchPeriodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
Bolado-Carrancio A, Rukhlenko O, Nikonova E, Tsyganov M, Wheeler A, Garcia-Munoz A, Kolch W, von Kriegsheim A, Kholodenko B. Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration. ELife 2020, 9: e58165. PMID: 32705984, PMCID: PMC7380942, DOI: 10.7554/elife.58165.Peer-Reviewed Original ResearchScaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*
Kiyatkin A, Aksamitiene E, Markevich NI, Borisov NM, Hoek JB, Kholodenko BN. Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*. Journal Of Biological Chemistry 2006, 281: 19925-19938. PMID: 16687399, PMCID: PMC2312093, DOI: 10.1074/jbc.m600482200.Peer-Reviewed Original ResearchUntangling the wires: A strategy to trace functional interactions in signaling and gene networks
Kholodenko BN, Kiyatkin A, Bruggeman FJ, Sontag E, Westerhoff HV, Hoek JB. Untangling the wires: A strategy to trace functional interactions in signaling and gene networks. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 12841-12846. PMID: 12242336, PMCID: PMC130547, DOI: 10.1073/pnas.192442699.Peer-Reviewed Original Research
2026
Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells
Imoto H, Rauch N, Nagasato A, Okada M, Kolch W, Rukhlenko O, Kholodenko B. Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells. Npj Systems Biology And Applications 2026 PMID: 41986383, DOI: 10.1038/s41540-026-00710-6.Peer-Reviewed Original ResearchPhase II Trial of Vemurafenib and Sorafenib Combination in Advanced KRAS-Mutated Metastatic Pancreatic Cancer.
Khawaja M, Jameson G, Cridebring D, Shannon P, Han H, Moore J, Von Hoff D, Posner R, Hlavacek W, Kolch W, Kholodenko B, Rukhlenko O, Roe D, Wertheim B, Borazanci E. Phase II Trial of Vemurafenib and Sorafenib Combination in Advanced KRAS-Mutated Metastatic Pancreatic Cancer. Journal Of Immunotherapy And Precision Oncology 2026, 9: 17-24. PMID: 41766762, PMCID: PMC12947236, DOI: 10.36401/jipo-25-20.Peer-Reviewed Original Research
2025
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
Yabaji S, Zhernovkov V, Araveti P, Lata S, Rukhlenko O, Al Abdullatif S, Vanvalkenburg A, Alekseyev Y, Ma Q, Dayama G, Lau N, Johnson W, Bishai W, Crossland N, Campbell J, Kholodenko B, Gimelbrant A, Kobzik L, Kramnik I. Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. ELife 2025, 14: rp106814. PMID: 41037321, PMCID: PMC12490860, DOI: 10.7554/elife.106814.Peer-Reviewed Original ResearchLipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
Yabaji S, Zhernovkov V, Araveti P, Lata S, Rukhlenko O, Abdullatif S, Vanvalkenburg A, Alekseyev Y, Ma Q, Dayama G, Lau N, Johnson W, Bishai W, Crossland N, Campbell J, Kholodenko B, Gimelbrant A, Kobzik L, Kramnik I. Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. ELife 2025, 14 DOI: 10.7554/elife.106814.2.Peer-Reviewed Original ResearchcSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling
Deng H, Rukhlenko O, Joshi D, Hu X, Junk P, Tuliakova A, Kholodenko B, Schwartz M. cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling. Science Advances 2025, 11: eado9970. PMID: 39752487, PMCID: PMC11698091, DOI: 10.1126/sciadv.ado9970.Peer-Reviewed Original Research