Alexander Ladenheim, MD
Assistant Professor of PathologyCards
About
Research
Publications
2026
High Rates of Synchronous Oncocytic Neoplasms and Papillary Thyroid Carcinomas: Are We Missing Something?
Haynes C, Mahoney F, Gabriel J, Rome C, Gibson C, Ogilvie J, Ladenheim A, Ramirez A. High Rates of Synchronous Oncocytic Neoplasms and Papillary Thyroid Carcinomas: Are We Missing Something? Journal Of Surgical Research 2026, 324: 261-270. PMID: 42263427, DOI: 10.1016/j.jss.2026.05.008.Peer-Reviewed Original Researchconcurrent papillary thyroid carcinomapapillary thyroid carcinomaoncocytic carcinomaoncocytic neoplasmsoncocytic adenomastumor sizemultivariate logistic regressionthyroid carcinomacoexistence of papillary thyroid carcinomarate of papillary thyroid carcinomaoncocytic subtypescalculated risk of malignancysingle-institution databaserisk of malignancylogistic regressiongeneral populationassociated with higher oddstumor locationtumor proximityoncocytic tumorsHigher Ratestumor typesmale sexOC patientsmutation profilesBiomarkers Associated With Extranodal Extension (ENE) in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Systematic Review
Williams L, Lorenzo N, Ladenheim A, Mehra S, Judson B, Pai S, Verma A, Sayed Z, Clohessy J, Roche A. Biomarkers Associated With Extranodal Extension (ENE) in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Systematic Review. Head & Neck 2026, 48: 2329-2340. PMID: 41887916, PMCID: PMC13432359, DOI: 10.1002/hed.70243.Peer-Reviewed Original Researchoropharyngeal squamous cell carcinomaassociated with extranodal extensionextranodal extensionsquamous cell carcinomaepithelial-mesenchymal transitioncell carcinomaHPV-negative oropharyngeal squamous cell carcinomamolecular biomarkerspresence of extranodal extensionhuman papillomavirus (HPV)-positivesystematic reviewexpression of podoplaninepithelial-mesenchymal transition phenotypeWnt mutationstumor tissuestreatment planningcancer cellsNotch-1inclusion criteriarelevant articlesbiomarkerscarcinomapatientsreviewHER3
2025
High-Risk HPV-Positive Sinonasal Adenocarcinoma: A Case Report and Review of Literature
Krasinski C, Verma A, Yu S, Ladenheim A. High-Risk HPV-Positive Sinonasal Adenocarcinoma: A Case Report and Review of Literature. Head And Neck Pathology 2025, 19: 114. PMID: 40983792, PMCID: PMC12454247, DOI: 10.1007/s12105-025-01845-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHyalinizing Clear Cell Carcinoma of the Head and Neck: A Multicenter Retrospective Study of 87 Cases Focusing on Prognostic Pathologic Features and Grading Scheme
Xu B, Viswanathan K, Barbesier M, Ladenheim A, Antonescu C, Ghossein R, Lubin D, Magliocca K, Matar S, Mikula M, Resta I, Roy D, Sohn S, Verma A, Prasad M, Rooper L, Brandwein-Weber M, Baloch Z, Katabi N. Hyalinizing Clear Cell Carcinoma of the Head and Neck: A Multicenter Retrospective Study of 87 Cases Focusing on Prognostic Pathologic Features and Grading Scheme. Modern Pathology 2025, 38: 100834. PMID: 40617532, PMCID: PMC12323664, DOI: 10.1016/j.modpat.2025.100834.Peer-Reviewed Original ResearchHyalinizing clear cell carcinomadistant metastasis-free survivaldisease-free survivaldisease-specific survivalpercentage of clear cellsrisk of nodal metastasistumor necrosisclear cell carcinomaprognostic factorsnodal metastasisatypical mitosisclear cellnuclear pleomorphismcell carcinomamitotic indexEWSR1 rearrangementeosinophilic cellsgrading systemsurvival analysissalivary glandssalivary gland carcinomasmetastasis-free survivalminor salivary glandsmulticenter retrospective studyunivariate survival analysis
2024
Psammoma bodies in thyroid: are they always indicative of malignancy? A multi-institutional study
Rossi E, Agarwal S, Erkilic S, Hang J, Jalaly J, Khanafshar E, Ladenheim A, Baloch Z. Psammoma bodies in thyroid: are they always indicative of malignancy? A multi-institutional study. Virchows Archiv 2024, 485: 853-858. PMID: 39349665, PMCID: PMC11564275, DOI: 10.1007/s00428-024-03934-1.Peer-Reviewed Original ResearchPCSK2 can be Useful in a Panel Approach to Distinguish Foregut and Midgut Neuroendocrine Tumors
Ladenheim A, Zheng J, Teklu A, Matsukuma K. PCSK2 can be Useful in a Panel Approach to Distinguish Foregut and Midgut Neuroendocrine Tumors. International Journal Of Surgical Pathology 2024, 33: 76-84. PMID: 39034588, DOI: 10.1177/10668969241260208.Peer-Reviewed Original ResearchDiagnosing B-cell acute lymphoblastic leukemia in 2 pediatric patients with recent SARS-CoV-2 infection
Mitra A, Ladenheim A, Datta-Mitra A, Honeychurch K, Dwyre D, Graff J. Diagnosing B-cell acute lymphoblastic leukemia in 2 pediatric patients with recent SARS-CoV-2 infection. Sage Open Pathology 2024, 17: 2632010x241278180. PMID: 39246689, PMCID: PMC11380119, DOI: 10.1177/2632010x241278180.Peer-Reviewed Original Research
2022
Benign Lung Adenoma Mimicking an Adenocarcinoma With EML4-ALK Gene Fusion
Hyde J, Kamangar E, Ladenheim A, Cooke D. Benign Lung Adenoma Mimicking an Adenocarcinoma With EML4-ALK Gene Fusion. Annals Of Thoracic Surgery Short Reports 2022, 1: 137-139. PMID: 39790518, PMCID: PMC11708699, DOI: 10.1016/j.atssr.2022.10.006.Peer-Reviewed Original ResearchHidden treasures: Incidental findings in two cases of chronic subdural hematoma
Ladenheim A, Mitra A, Lechpammer M, Dwyre D. Hidden treasures: Incidental findings in two cases of chronic subdural hematoma. Surgical Neurology International 2022, 13: 267. PMID: 35855153, PMCID: PMC9282790, DOI: 10.25259/sni_828_2021.Peer-Reviewed Original Research
2021
Primary Angiosarcoma of the Adrenal Gland: Report of 2 Cases and Review of the Literature
Ladenheim A, Tian M, Afify A, Campbell M, Kamangar E. Primary Angiosarcoma of the Adrenal Gland: Report of 2 Cases and Review of the Literature. International Journal Of Surgical Pathology 2021, 30: 76-85. PMID: 34029146, DOI: 10.1177/10668969211020099.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements