2016
Cocaine cue–induced dopamine release in the human prefrontal cortex
Milella M, Fotros A, Gravel P, Casey K, Larcher K, Verhaeghe J, Cox S, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine cue–induced dopamine release in the human prefrontal cortex. Journal Of Psychiatry And Neuroscience 2016, 41: 322-330. PMID: 26900792, PMCID: PMC5008921, DOI: 10.1503/jpn.150207.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzamidesBrain MappingCocaineCocaine-Related DisordersCorpus StriatumCravingCuesDopamineDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsFemaleFluorine RadioisotopesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPrefrontal CortexRadiopharmaceuticalsConceptsDA releaseMedial orbitofrontal cortexPrefrontal cortexDrug-related cuesDopamine releaseHuman prefrontal cortexOrbitofrontal cortexCortical DA releasePresence of autoreceptorsDA cell bodiesD2 receptor levelsD2/3 receptor availabilityCurrent cocaine dependencePositron emission tomographyCocaine use disorderDorsolateral prefrontal cortexSelf-reported cravingStriatal changesHigh-resolution positron emission tomographyReceptor levelsSeparate regulatory mechanismsStriatal regionsDA responseUse disordersReceptor availability
2013
Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants
Fotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.Peer-Reviewed Original ResearchConceptsDA releaseDopamine releaseVisual analog scaleDrug cue exposureCocaine-dependent volunteersDrug-seeking behaviorCocaine-dependent participantsAnalog scaleDrug-related cuesLimbic networkAnimal studiesCocaine dependenceHippocampusCue exposureAmygdalaPreferential inductionBPND valuesPotent triggerStriatumDependent participantsCocaine cuesReward networkSubjective responsesNeutral cuesFirst evidence
2012
External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET
Wiebking C, Duncan N, Qin P, Hayes D, Lyttelton O, Gravel P, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Bajbouj M, Northoff G. External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET. Human Brain Mapping 2012, 35: 173-184. PMID: 22996793, PMCID: PMC6869063, DOI: 10.1002/hbm.22166.Peer-Reviewed Original ResearchConceptsNeuronal activity changesInhibitory neurotransmitter GABANegative BOLD responseFunctional magnetic resonance imaging paradigmCortical midline regionsSame healthy subjectsGABAA receptorsHealthy subjectsNeurotransmitter GABAPsychiatric disordersBiochemical mechanismsPET imagingExtrinsic systemMidline regionBOLD responseExternal awarenessNeuronal networksUnderlying neuronal networksImaging paradigmGABAActivity changesStimulus typeSame paradigmAwarenessPrecuneus
2009
Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke
Massaweh G, Schirrmacher E, la Fougere C, Kovacevic M, Wängler C, Jolly D, Gravel P, Reader A, Thiel A, Schirrmacher R. Improved work-up procedure for the production of [18F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke. Nuclear Medicine And Biology 2009, 36: 721-727. PMID: 19720284, DOI: 10.1016/j.nucmedbio.2009.05.008.Peer-Reviewed Original Research
2008
Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers
Sibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy J, Zimmer L, Descarries L. Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers. Biological Psychiatry 2008, 63: 1135-1140. PMID: 18191817, DOI: 10.1016/j.biopsych.2007.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive Agents, Second-GenerationAutoreceptorsBrainDouble-Blind MethodFluorine RadioisotopesFluoxetineHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePiperazinesPositron-Emission TomographyPyridinesRaphe NucleiReceptor, Serotonin, 5-HT1AReference Values