2017
Posterior dopamine D2/3 receptors and brain network functional connectivity
Nagano‐Saito A, Lissemore J, Gravel P, Leyton M, Carbonell F, Benkelfat C. Posterior dopamine D2/3 receptors and brain network functional connectivity. Synapse 2017, 71 PMID: 28700819, DOI: 10.1002/syn.21993.Peer-Reviewed Original ResearchConceptsDefault mode networkNetwork functional connectivityFunctional connectivity strengthPositron emission tomographyFunctional connectivityPosterior portionReceptor distributionPosteromedial cortexResting-state functional magnetic resonance imagingConnectivity strengthBrain network functional connectivityPosterior default mode networkMode networkDopamine D2/3 receptorsDopamine receptor distributionResting-state connectivityBrain networksFunctional magnetic resonance imagingMagnetic resonance imagingMultiple brain networksFallypride bindingDorsal attention networkMean BPBrain dopamineD2/3 receptors
2016
Cocaine cue–induced dopamine release in the human prefrontal cortex
Milella M, Fotros A, Gravel P, Casey K, Larcher K, Verhaeghe J, Cox S, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine cue–induced dopamine release in the human prefrontal cortex. Journal Of Psychiatry And Neuroscience 2016, 41: 322-330. PMID: 26900792, PMCID: PMC5008921, DOI: 10.1503/jpn.150207.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzamidesBrain MappingCocaineCocaine-Related DisordersCorpus StriatumCravingCuesDopamineDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsFemaleFluorine RadioisotopesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPrefrontal CortexRadiopharmaceuticalsConceptsDA releaseMedial orbitofrontal cortexPrefrontal cortexDrug-related cuesDopamine releaseHuman prefrontal cortexOrbitofrontal cortexCortical DA releasePresence of autoreceptorsDA cell bodiesD2 receptor levelsD2/3 receptor availabilityCurrent cocaine dependencePositron emission tomographyCocaine use disorderDorsolateral prefrontal cortexSelf-reported cravingStriatal changesHigh-resolution positron emission tomographyReceptor levelsSeparate regulatory mechanismsStriatal regionsDA responseUse disordersReceptor availability
2014
Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study
Booij L, Soucy J, Young S, Regoli M, Gravel P, Diksic M, Leyton M, Pihl R, Benkelfat C. Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha‐[11C]methyl‐l‐tryptophan study. Journal Of Neurochemistry 2014, 131: 634-644. PMID: 25041501, DOI: 10.1111/jnc.12826.Peer-Reviewed Original ResearchConceptsMDMA polydrug usersMDMA usePolydrug usersLong-term neurotoxic effectsBrain serotonin synthesisSerotonin synthesis capacityDistal brain regionsNeurotoxicity of MDMAPositron emission tomographySynthesis capacityTracer alphaSerotonin synthesisNeurotoxic effectsPre-frontal regionsTemporal areaBrain regionsEmission tomographyCompensatory mechanismsTryptophan studiesParietal regionsMethylenedioxymethamphetamine (MDMA) useLonger durationBrainstemMDMA users
2012
External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET
Wiebking C, Duncan N, Qin P, Hayes D, Lyttelton O, Gravel P, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Bajbouj M, Northoff G. External awareness and GABA—A multimodal imaging study combining fMRI and [18F]flumazenil‐PET. Human Brain Mapping 2012, 35: 173-184. PMID: 22996793, PMCID: PMC6869063, DOI: 10.1002/hbm.22166.Peer-Reviewed Original ResearchConceptsNeuronal activity changesInhibitory neurotransmitter GABANegative BOLD responseFunctional magnetic resonance imaging paradigmCortical midline regionsSame healthy subjectsGABAA receptorsHealthy subjectsNeurotransmitter GABAPsychiatric disordersBiochemical mechanismsPET imagingExtrinsic systemMidline regionBOLD responseExternal awarenessNeuronal networksUnderlying neuronal networksImaging paradigmGABAActivity changesStimulus typeSame paradigmAwarenessPrecuneus
2010
Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET
la Fougère C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [18F]flumazenil-PET. NeuroImage 2010, 56: 951-960. PMID: 21073964, DOI: 10.1016/j.neuroimage.2010.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBrain MappingCerebral CortexData Interpretation, StatisticalFemaleFlumazenilGABA ModulatorsHumansImage Processing, Computer-AssistedIndividualityIsotope LabelingMagnetic Resonance ImagingMaleMiddle AgedNeuronsPositron-Emission TomographyRadiopharmaceuticalsReceptors, GABARegression AnalysisConceptsNeuronal densityCortical thicknessAxo-dendritic synapsesSensory-motor cortexHuman brain areasDifferent cytoarchitectonic areasFlumazenil PETMotor cortexApparent cortical thicknessCortical thickness mapsHealthy subjectsBrain areasMorphometry studyCytoarchitectonic areasCortical morphologyCortical regionsCortical distributionVivo studiesFMZReceptor complexPartial volume correctionCytoarchitectonicsSensitive toolDifferential relationshipsSubset
2006
Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping
Sibon I, Strafella A, Gravel P, Ko J, Booij L, Soucy J, Leyton M, Diksic M, Benkelfat C. Acute prefrontal cortex TMS in healthy volunteers: Effects on brain 11C-αMtrp trapping. NeuroImage 2006, 34: 1658-1664. PMID: 17188517, DOI: 10.1016/j.neuroimage.2006.08.059.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationLeft dorsolateral prefrontal cortexAcute repetitive transcranial magnetic stimulationLeft occipital cortexHealthy volunteersLimbic areasMajor depressionHigh-frequency repetitive transcranial magnetic stimulationHz repetitive transcranial magnetic stimulationPrefrontal repetitive transcranial magnetic stimulationRight cingulate gyrusSerotonin synthesis capacityTranscranial magnetic stimulationAutonomic measuresLeft parahippocampal gyrusDorsolateral prefrontal cortexMechanism of actionRTMS sessionsBrain uptakeRandomized counterbalanced orderCingulate gyrusRight insulaOccipital cortexMagnetic stimulationParahippocampal gyrus
2005
α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingPrefrontal cortexHealthy controlsSerotonin synthesisSuicidal behaviorSuicide attemptersRegional serotonin synthesisHigh-lethality suicide attemptsVentral medial prefrontal cortexLow serotonin neurotransmissionMedial prefrontal cortexSerotonin neurotransmissionVentromedial prefrontal cortexSuicide attemptsSuicide intentCortexAlphaAttemptersPatientsNeurotransmission