Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study
Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay R. Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study. European Neuropsychopharmacology 2012, 22: 419-423. PMID: 22257439, DOI: 10.1016/j.euroneuro.2011.11.002.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexSerotonin neurotransmissionPerinatal adversityPositron emission tomography scanEarly postnatal stressorsLow birth weightEmission tomography scanBrain serotonin neurotransmissionBrain serotonin synthesisSerotonin synthesis capacityStudies reporting associationLongitudinal studyMental health problemsEffects of childhoodLife-long impactTracer alphaMaternal smokingPerinatal effectsBirth complicationsBirth weightRisk factorsTomography scanSerotonin pathwaySerotonin synthesis