Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline
Lissemore J, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl T, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C. Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. Translational Psychiatry 2018, 8: 82. PMID: 29666372, PMCID: PMC5904107, DOI: 10.1038/s41398-018-0128-4.Peer-Reviewed Original ResearchConceptsSerotonin synthesis capacitySelective serotonin reuptake inhibitorsCognitive behavioral therapyObsessive-compulsive disorderPartial respondersTreatment modalitiesMedication-free OCD patientsBehavioral therapyOCD patientsSerotonin reuptake inhibitorsWeeks of treatmentRegional tracer uptakePost-treatment changesPositron emission tomographySynthesis capacityClinical improvementSSRI treatmentReuptake inhibitorsSertraline treatmentSymptom improvementRaphe nucleusNeurochemical changesSerotonergic toneSymptom responseEffective treatment