Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers
Sibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy J, Zimmer L, Descarries L. Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers. Biological Psychiatry 2008, 63: 1135-1140. PMID: 18191817, DOI: 10.1016/j.biopsych.2007.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive Agents, Second-GenerationAutoreceptorsBrainDouble-Blind MethodFluorine RadioisotopesFluoxetineHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePiperazinesPositron-Emission TomographyPyridinesRaphe NucleiReceptor, Serotonin, 5-HT1AReference ValuesConceptsPositron emission tomography studySerotonin 1A autoreceptorsEndogenous ligandTomography studySpecific bindingAutoreceptorsAgonistsRadioligand