2017
Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia
Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy J, Gravel P, Dang-Vu T. Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia. Sleep 2017, 40: zsx140. PMID: 28958044, DOI: 10.1093/sleep/zsx140.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowIdiopathic hypersomniaBlood flowMedial prefrontal cortexSingle photon emissionDaytime sleepinessAltered regional cerebral blood flowRegional cerebral blood flow distributionRegional cerebral blood flow changesCerebral blood flow decreasesRegional cerebral blood flow decreasesCerebral blood flow distributionPrefrontal cortexCerebral blood flow changesBlood flow decreaseBrain perfusion patternsExcessive daytime sleepinessEye movement sleepBlood flow changesBlood flow distributionTemporo-occipital cortexAcute sleep deprivationPhoton emissionPosterior cingulate cortex
2013
Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteers
Nagano‐Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey K, Leyton M, Benkelfat C. Stress‐induced dopamine release in human medial prefrontal cortex—18F‐Fallypride/PET study in healthy volunteers. Synapse 2013, 67: 821-830. PMID: 23939822, DOI: 10.1002/syn.21700.Peer-Reviewed Original ResearchConceptsStress-induced dopamine releaseDopamine releaseHeart ratePsychological stressorsMesocortical dopamine releaseHealthy young adultsSalivary cortisol levelsStress-induced increaseMedial prefrontal cortexPositron emission tomographyMesocortical dopamine systemStress-induced decreasePresent studyTissue compartmental modelMotor zoneHealthy volunteersRostal partDopamine systemCortisol levelsWhole brainBP NDDorsal partSeparate daysEmission tomographyPET studies
2008
MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF study
Aznavour N, Benkelfat C, Gravel P, Aliaga A, Rosa-Neto P, Bedell B, Zimmer L, Descarries L. MicroPET imaging of 5-HT1A receptors in rat brain: a test–retest [18F]MPPF study. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 36: 53. PMID: 18704404, DOI: 10.1007/s00259-008-0891-1.Peer-Reviewed Original ResearchConceptsPositron emission tomographyRaphe nucleusIsoflurane-anaesthetised ratsParaventricular hypothalamic nucleusMedial prefrontal cortexTest-retest variabilityNon-human primatesSimplified reference tissue modelReference tissue modelHypothalamic nucleiRaphe obscurusMagnetic resonance imaging dataBasolateral amygdaloidRat brainLarge brain regionsParaventricular hypothalamicBrain regionsEmission tomographyReceptor functionPrefrontal cortexMicroPET imagingBrain imagingRatsPotential of serotoninReceptors
2005
α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingPrefrontal cortexHealthy controlsSerotonin synthesisSuicidal behaviorSuicide attemptersRegional serotonin synthesisHigh-lethality suicide attemptsVentral medial prefrontal cortexLow serotonin neurotransmissionMedial prefrontal cortexSerotonin neurotransmissionVentromedial prefrontal cortexSuicide attemptsSuicide intentCortexAlphaAttemptersPatientsNeurotransmission