2011
Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
Booij L, Turecki G, Leyton M, Gravel P, Lopez De Lara C, Diksic M, Benkelfat C. Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans. Molecular Psychiatry 2011, 17: 809-817. PMID: 21747395, DOI: 10.1038/mp.2011.79.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin synthesisTryptophan hydroxylase 2Orbitofrontal cortexRate-limiting enzymeSingle nucleotide polymorphismsL-tryptophan trappingRegional serotonin synthesisBrain serotonin synthesisTPH2 single nucleotide polymorphismsDose-effect relationshipBrain clearanceHealthy controlsGene polymorphismsAggressive behavioral phenotypeEmission tomographyHydroxylase 2TPH2 geneGenetic factorsCortexBehavioral phenotypesPolymorphismPatientsHumansLarge sampleBrain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder
Berney A, Leyton M, Gravel P, Sibon I, Sookman D, Neto P, Diksic M, Nakai A, Pinard G, Todorov C, Okazawa H, Blier P, Nordahl T, Benkelfat C. Brain Regionalα-[11C]Methyl-L-Tryptophan Trapping in Medication-Free Patients With Obsessive-Compulsive Disorder. JAMA Psychiatry 2011, 68: 732-741. PMID: 21383250, PMCID: PMC3677917, DOI: 10.1001/archgenpsychiatry.2011.16.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingObsessive-compulsive disorderMedication-free patientsHealthy controlsMcGill University Health CentreGlucose metabolic disturbancesAdults meeting criteriaMain outcome measuresUniversity Health CentrePositron emission tomographyDepartment of PsychiatryStatistical parametric mappingTemporal lobe activityMontreal Neurological InstituteSerotonergic componentReuptake inhibitorsSerotonin dysfunctionClinical efficacySerotonergic abnormalitiesMetabolic disturbancesPostsynaptic changesSymptomatic stateSerotonergic systemHealth centersOutcome measures
2005
α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingPrefrontal cortexHealthy controlsSerotonin synthesisSuicidal behaviorSuicide attemptersRegional serotonin synthesisHigh-lethality suicide attemptsVentral medial prefrontal cortexLow serotonin neurotransmissionMedial prefrontal cortexSerotonin neurotransmissionVentromedial prefrontal cortexSuicide attemptsSuicide intentCortexAlphaAttemptersPatientsNeurotransmission