2017
Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV
Aghourian M, Legault-Denis C, Soucy J, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard M. Quantification of brain cholinergic denervation in Alzheimer’s disease using PET imaging with [18F]-FEOBV. Molecular Psychiatry 2017, 22: 1531-1538. PMID: 28894304, DOI: 10.1038/mp.2017.183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCase-Control StudiesCholinergic AgentsCholinergic NeuronsFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPiperidinesPositron-Emission TomographyPresynaptic TerminalsRadioactive TracersVesicular Acetylcholine Transport ProteinsConceptsMini-Mental State ExaminationStandardized uptake value ratioAlzheimer's diseaseCortical areasPresynaptic cholinergic nerve terminalsAmyloid-beta tracerNumerous cortical areasCognitive scalesCholinergic nerve terminalsUptake value ratioVesicular acetylcholine transporterMultiple cortical areasNew PET radiotracersVoxel-wise t-testsCholinergic denervationCholinergic terminalsCholinergic degenerationControl subjectsAD patientsCholinergic lossNerve terminalsAD groupHealthy subjectsAcetylcholine transporterAD subjects
2010
P1‐388: Imaging of cholinergic terminals in the non‐human primate brain using 18F‐FEOBV PET: Development of a tool to assess cholinergic losses in Alzheimer's disease
Soucy J, Rosa P, Massarweh G, Aliaga A, Schirrmacher E, Bédard M, Sanchez-Legaspi M, Gravel P, Reader A. P1‐388: Imaging of cholinergic terminals in the non‐human primate brain using 18F‐FEOBV PET: Development of a tool to assess cholinergic losses in Alzheimer's disease. Alzheimer's & Dementia 2010, 6: s286-s286. DOI: 10.1016/j.jalz.2010.05.942.Peer-Reviewed Original ResearchNon-human primate brainCholinergic terminalsCholinergic lossPrimate brainAlzheimer's diseaseDiseaseBrain