2024
NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS
Thaw-Poon S, Blondin N, Liu Y, Corbin Z, Baehring J, Omuro A, Moliterno J, Omay S, Fulbright R, de Graaf R, De Feyter H. NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS. Neuro-Oncology 2024, 26: viii201-viii201. PMCID: PMC11553074, DOI: 10.1093/neuonc/noae165.0795.Peer-Reviewed Original ResearchGrade 2 lesionsTumor gradeDeuterium metabolic imagingMetabolic imagingNon-enhancing tumor regionsBrain tumorsTumor-to-brain contrastTumour-specific valuesActive tumor tissueImage contrastVOI-based analysisGrade 4Evaluate disease progressionTesla MRI scannerFDG-PETGrade 3Lesion gradeTumor tissuesDisease progressionDisease stageOral administrationTumorObservational studyNormal brainContrast enhancementNIMG-32. ORAL ADMINISTRATION OF DEUTERATED CHOLINE AS A NEW APPROACH TO PROVIDE HIGH TUMOR-TO-BRAIN IMAGE CONTRAST IN DEUTERIUM METABOLIC IMAGING (DMI)
Osoliniec V, Thomas M, de Graaf R, De Feyter H. NIMG-32. ORAL ADMINISTRATION OF DEUTERATED CHOLINE AS A NEW APPROACH TO PROVIDE HIGH TUMOR-TO-BRAIN IMAGE CONTRAST IN DEUTERIUM METABOLIC IMAGING (DMI). Neuro-Oncology 2024, 26: viii202-viii202. PMCID: PMC11552881, DOI: 10.1093/neuonc/noae165.0797.Peer-Reviewed Original ResearchTumor-to-brain contrastOral administrationMetabolic imagingDeuterium metabolic imagingIV infusionTCho concentrationOrthotopic models of glioblastomaNormal brainContralateral normal brainTumor-to-brainDays of oral administrationModels of glioblastomaAdministration of cholineTesla MRI scannerTCho signalMg/kg body weightOrthotopic modelFDG-PETOral administration of cholineTotal cholineDaily doseIntravenous infusionF344 ratsTail veinCholine metabolitesHigh-quality lipid suppression and B0 shimming for human brain 1H MRSI
Kumaragamage C, McIntyre S, Nixon T, De Feyter H, de Graaf R. High-quality lipid suppression and B0 shimming for human brain 1H MRSI. NeuroImage 2024, 300: 120845. PMID: 39276817, PMCID: PMC11540284, DOI: 10.1016/j.neuroimage.2024.120845.Peer-Reviewed Original ResearchOuter volume suppressionInner volume selectionSlice coverageField shimmingLipid suppressionMRSI acquisitionMagnetic field shimmingMagnetic resonance spectroscopic imagingSpherical harmonic fieldsBrain non-invasivelyAxial coverageMulti-coilRadio frequencyVolume suppressionB0 shimmingBrain coverageGradient coilsHarmonic fieldVolume selectionGradient insertShimming performancePhantom experimentsField variationsSpectroscopic imagingProton magnetic resonance spectroscopic imagingLipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Lipid removal in deuterium metabolic imaging (DMI) using spatial prior knowledge. Magnetic Resonance 2024, 5: 21-31. DOI: 10.5194/mr-5-21-2024.Peer-Reviewed Original Research
2023
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma
Khang M, Lee J, Lee T, Suh H, Lee S, Cavaliere A, Rushing A, Geraldo L, Belitzky E, Rossano S, de Feyter H, Shin K, Huttner A, Roussel M, Thomas J, Carson R, Marquez-Nostra B, Bindra R, Saltzman W. Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma. Science Translational Medicine 2023, 15: eadi1617. PMID: 37910601, PMCID: PMC11078331, DOI: 10.1126/scitranslmed.adi1617.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidDelivery of drugsEffective therapyTherapeutic indexPARP inhibitorsBlood-brain barrierSite of tumorRapid systemic clearanceXenograft mouse modelSolvent evaporation processAdministration of substancesLeptomeningeal spreadIntrathecal deliveryLeptomeningeal metastasesBrain penetrationSystemic clearanceTumor regressionPolymer nanoparticlesMetastatic medulloblastomaMouse modelPediatric medulloblastomaDrug accumulationCSF turnoverEncapsulated drugsPET imagingImaging metabolism of deuterated glucose in patients with primary brain tumors
Corbin Z, Liu Y, Fulbright R, Thaw-Poon S, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Rothman D, de Graaf R, De Feyter H. Imaging metabolism of deuterated glucose in patients with primary brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0142.Peer-Reviewed Original ResearchIn vivo demonstration of arbitrary ROI shaping and B0 shimming with MC-ECLIPSE for applications in human brain proton MRSI
Kumaragamage C, McIntyre S, Nixon T, De Feyter H, de Graaf R. In vivo demonstration of arbitrary ROI shaping and B0 shimming with MC-ECLIPSE for applications in human brain proton MRSI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/1238.Peer-Reviewed Original ResearchParallel Proton and Deuterium Metabolic Imaging
Liu Y, Kumaragamage C, Nixon T, McIntyre S, De Feyter H, de Graaf R. Parallel Proton and Deuterium Metabolic Imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3870.Peer-Reviewed Original ResearchExpanding interleaved MRI-DMI to 3D SWI (Susceptibility Weighted Imaging) : A truncated acquisition approach
Liu Y, Corbin Z, Fulbright R, Nixon T, McIntyre S, De Feyter H, de Graaf R. Expanding interleaved MRI-DMI to 3D SWI (Susceptibility Weighted Imaging) : A truncated acquisition approach. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0013.Peer-Reviewed Original ResearchRobust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge
de Graaf R, Liu Y, Corbin Z, De Feyter H. Robust and Automated Processing of Deuterium Metabolic Imaging (DMI) using Spatial Prior Knowledge. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/4107.Peer-Reviewed Original ResearchIndirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas
Autry A, LaFontaine M, Villanueva-Meyer J, Chang S, de Feyter H, Li Y. Indirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/2502.Peer-Reviewed Original ResearchIndirect detectionMagnetic resonance spectroscopic imagingAnterior cingulate cortexSingle-voxel spectroscopyGlucose metabolismLevels of glutamateSpectroscopic imagingReduced levels of glutamateGlucose brain metabolismT2 lesionsHealthy subjectsCingulate cortexBrain tumorsTeslaPatientsBrain metabolismGray matterPreliminary dataReduced levelsMetabolismMapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated cholinePreclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Chen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.Peer-Reviewed Original ResearchConceptsPositron emission tomographyHealthy nonhuman primatesVolume of distributionDistribution volume ratioBrain kineticsRat glioblastoma modelPreclinical evaluationBrain regionsGlioblastoma modelPET tracersNonhuman primatesTumor-bearing ratsEx vivo biodistributionPET imaging resultsActive clinical trialsTreatment of glioblastomaHigh specific uptakeDynamic PET scansNoninvasive quantificationBrain positron emission tomographyNondisplaceable volumeBrain penetrationLow nonspecific uptakePrognostic informationClinical trialsIn vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2022
Deuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchDeuterium Metabolic Imaging of the Human Brain in vivo at 7T
Roig E, De Feyter H, Nixon T, Ruhm L, Avdievich N, Henning A, de Graaf R. Deuterium Metabolic Imaging of the Human Brain in vivo at 7T. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/0635.Peer-Reviewed Original Research
2021
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Reports 2021, 36: 109475. PMID: 34320362, DOI: 10.1016/j.celrep.2021.109475.Peer-Reviewed Original ResearchDeuterium metabolic imaging – Back to the future
De Feyter HM, de Graaf RA. Deuterium metabolic imaging – Back to the future. Journal Of Magnetic Resonance 2021, 326: 106932. PMID: 33902815, PMCID: PMC8083995, DOI: 10.1016/j.jmr.2021.106932.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNMR visibility of deuterium‐labeled liver glycogen in vivo
De Feyter HM, Thomas MA, Behar KL, de Graaf R. NMR visibility of deuterium‐labeled liver glycogen in vivo. Magnetic Resonance In Medicine 2021, 86: 62-68. PMID: 33590529, PMCID: PMC8005460, DOI: 10.1002/mrm.28717.Peer-Reviewed Original Research
2020
Characterization of Kinetic Isotope Effects and Label Loss in Deuterium-Based Isotopic Labeling Studies
de Graaf RA, Thomas MA, Behar KL, De Feyter HM. Characterization of Kinetic Isotope Effects and Label Loss in Deuterium-Based Isotopic Labeling Studies. ACS Chemical Neuroscience 2020, 12: 234-243. PMID: 33319987, PMCID: PMC9890388, DOI: 10.1021/acschemneuro.0c00711.Peer-Reviewed Original Research