2020
Blebs in intracranial aneurysms: prevalence and general characteristics
Ashkezari S, Detmer F, Mut F, Chung B, Yu A, Stapleton C, See A, Amin-Hanjani S, Charbel F, Jahromi B, Niemelä M, Frösen J, Zhou J, Maiti S, Robertson A, Cebral J. Blebs in intracranial aneurysms: prevalence and general characteristics. Journal Of NeuroInterventional Surgery 2020, 13: 226-230. PMID: 32680877, PMCID: PMC8294207, DOI: 10.1136/neurintsurg-2020-016274.Peer-Reviewed Original ResearchConceptsAssociated with dental infectionDental infectionsIntracranial aneurysmsPercentage of aneurysmsHormone therapyPresence of blebsAssociated with hormone replacement therapyHormone replacement therapyHistory of hypertensionInternal carotid arteryReplacement therapyClinical factorsAneurysmVascular reconstructionCarotid arteryAneurysm neckRisk factorsMultiple blebsTherapyAngiographic imagesNeckInfectionRupture risk factorsBlebsHypertension
2019
Extending statistical learning for aneurysm rupture assessment to Finnish and Japanese populations using morphology, hemodynamics, and patient characteristics.
Detmer F, Hadad S, Chung B, Mut F, Slawski M, Juchler N, Kurtcuoglu V, Hirsch S, Bijlenga P, Uchiyama Y, Fujimura S, Yamamoto M, Murayama Y, Takao H, Koivisto T, Frösen J, Cebral J. Extending statistical learning for aneurysm rupture assessment to Finnish and Japanese populations using morphology, hemodynamics, and patient characteristics. Neurosurgical FOCUS 2019, 47: e16. PMID: 31261120, PMCID: PMC7132362, DOI: 10.3171/2019.4.focus19145.Peer-Reviewed Original ResearchConceptsArea under the receiver operating characteristic curveFinnish patientsPatient populationRisks associated with treatmentReceiver operating characteristic curveRupture riskInteraction termsAneurysm characteristicsIncidental aneurysmsModels' area under the receiver operating characteristic curvePatient characteristics
2018
Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location
Detmer F, Chung B, Jimenez C, Hamzei-Sichani F, Kallmes D, Putman C, Cebral J. Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location. Neuroradiology 2018, 61: 275-284. PMID: 30456458, PMCID: PMC6403015, DOI: 10.1007/s00234-018-2135-9.Peer-Reviewed Original ResearchConceptsHigh wall shear stressWall shear stressOscillatory shearAdverse hemodynamic environmentShear stressComplex flowHemodynamic environmentComplex shapesImage-based modelingIrregular shapeMorphologySidewall aneurysmsBifurcationFlowSidewallShearShapeAdverse hemodynamicsMiddle cerebral arteryInternal carotid arteryExternal validation of cerebral aneurysm rupture probability model with data from two patient cohorts
Detmer F, Fajardo-Jiménez D, Mut F, Juchler N, Hirsch S, Pereira V, Bijlenga P, Cebral J. External validation of cerebral aneurysm rupture probability model with data from two patient cohorts. Acta Neurochirurgica 2018, 160: 2425-2434. PMID: 30374656, PMCID: PMC6290995, DOI: 10.1007/s00701-018-3712-8.Peer-Reviewed Original ResearchDevelopment and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics
Detmer F, Chung B, Mut F, Slawski M, Hamzei-Sichani F, Putman C, Jiménez C, Cebral J. Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics. International Journal Of Computer Assisted Radiology And Surgery 2018, 13: 1767-1779. PMID: 30094777, PMCID: PMC6328054, DOI: 10.1007/s11548-018-1837-0.Peer-Reviewed Original ResearchConceptsArea under the curveAneurysm locationMaximum oscillatory shear indexImage-based computational fluid dynamicsOscillatory shear indexComputational fluid dynamicsLow shear areaRisk of surgeryShear areaAdverse hemodynamic environmentShear indexFluid dynamicsHemodynamic environmentGeometric parametersPatient ageEndovascular treatmentIncreased rupture riskSubarachnoid hemorrhageAneurysm ruptureUnruptured aneurysmsPatient characteristicsTreatment strategiesInternal validityMale genderPatient gender