Henk M. De Feyter, PhD

Associate Research Scientist of Diagnostic Radiology

De Feyter, Henk

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, N136, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: henk.defeyter@yale.edu
Telephone: (203) 785-4965
Fax: (203) 785-6643

Education

(2002-2007) PhD in the Biomedical NMR group of Prof. K. Nicolay, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

(1999-2002) M.Sc in Health Sciences, main subject: Human Movement Sciences, Maastricht University, The Netherlands

(1994-1999) M.Sc in Rehabilitation & Physical therapy, Ghent University, Belgium

Please click here for Curriculum Vitae

Research Interests

In general, my research interest involves metabolism in healthy and pathological conditions. In vivo Magnetic Resonance Spectroscopy (MRS) plays a key role in this physiological orientated research and is used in human studies as well as in rodent studies. Thus far I have studied skeletal muscle mitochondrial function in type 2 diabetes using 1H and 31P MRS, work which was predominantly carried out in the Biomedical NMR lab of Prof. Klaas Nicolay at the Eindhoven University of Technology. After recently moving to the Yale Magnetic Resonance Research Center and joining Prof. Douglas Rothman as a postdoc, my research area broadened, now also including in vivo 13C MRS and the infusion of 13C labeled substrates to study alterations in brain metabolism in relation to type 1 diabetes.

Selected Publications

  1. De Feyter HM, Lenaers E, Houten SM, Schrauwen P, Hesselink MK, Wanders RJA, Nicolay K, Prompers JJ: Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. In FASEB Journal, 2008, Epub ahead of print.
  2. De Feyter HM, Van Den Broek N, Praet SF, Nicolay K, van Loon LJ, Prompers J: Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction. In European Journal of Endocrinology, 2008, p. 643-653.
  3. De Feyter HM, Praet SF, van den Broek NM, Kuipers H, Stehouwer CD, Nicolay K, Prompers JJ, van Loon LJ: Exercise training improves glycemic control in long-standing insulin-treated type 2 diabetic patients. In Diabetes Care, 2007, p. 2511-2513.
  4. van den Broek NMA, De Feyter HM, de Graaf RA, Nicolay K, Prompers JJ: Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates. In Am J Physiol Cell Physiol, 2007, p. 228-237.
  5. Praet SF, De Feyter HM, Jonkers RA, Nicolay K, Pul C, Kuipers H, Loon LJ, Prompers JJ: (31)P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patients. In Magn Reson Mater Phy, 2006, p. 321-331.
  6. De Feyter HM, Schaart G, Hesselink MK, Schrauwen P, Nicolay K, Prompers JJ: Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle. In Magnetic Resonance in Medicine, 2006, p. 19-25.